Disease relevance of Paranasal Sinuses

• In conclusion, the NO concentration present in paranasal sinuses appears to partially suppress (approximately 20-40%) O2-* production from polyp eosinophils [1].
• A case-control study of cancer of the nose and paranasal sinuses was conducted in France to determine whether occupational exposure to formaldehyde was associated with an increased risk of sinonasal cancer [2].
• Use of gadolinium-enhanced MR imaging for differentiating mucoceles from neoplasms in the paranasal sinuses [3].
• CEA and NCA transcripts were, however, present in an adenocarcinoma located in the nasal sinuses [4].
• Olfactory neuroblastoma (ONB) is a highly vascularized and malignant tumor arising in olfactory neuronal precursors from the paranasal sinuses [5].

High impact information on Paranasal Sinuses

• Nitric oxide produced within the paranasal sinuses is considered to provide an antibacterial environment and to modulate mucociliary clearance function [6].
• In patients carrying PPB, antiseptic regimens could be crucial for infection control after major operations on or injuries of the head, nasal sinuses, or lungs [7].
• Carbon monoxide is endogenously produced in the human nose and paranasal sinuses [8].
• Computed tomographic study of the paranasal sinuses in allergic rhinitis [9].
• Paranasal sinuses were examined by coronal sinus computed tomographic scan [10].

Chemical compound and disease context of Paranasal Sinuses

• Coronal CT of the paranasal sinuses and the ostiomeatal complex (OMC) was performed before and 12 months after bilateral functional endoscopic sinus surgery (FESS) in 30 patients with sinusitis and 12 patients with nasal polyposis [11].
• Cholesterol granuloma is rare in the paranasal sinuses [12].
• There was a highly significant increased risk of cancer of the nose and nasal sinuses, which may be caused by exposure to nickel or cadmium or a combination of both exposures [13].
• The present study was conducted to compare its delivery of either a normal saline (NS) or a betamethasone solution (0.4 mg/ml) into the paranasal sinuses of 25 patients (39 sides) with chronic sinusitis [14].
• Sarcoidosis of the paranasal sinuses treated with hydroxychloroquine [15].

Biological context of Paranasal Sinuses

• Nitric oxide (NO) is an important modulator of leucocyte-endothelial cell interactions, endogenously produced in large quantities in the paranasal sinuses [16].

Anatomical context of Paranasal Sinuses

• Cancer of the nasal cavity and paranasal sinuses, and formaldehyde exposure [17].
• Comparison of two bacampicillin therapeutic regimens in infections of middle ear, pharynx and paranasal sinuses [18].
• The extent of tumour in the paranasal sinuses and anterior cranial fossa is best assessed with MRI after intravenous gadolinium, and this is considered as the most accurate method for assessing preoperative resectability [19].
• In this study, we summarize 47 epidemiologic studies related to formaldehyde exposure and use meta-analytic techniques to assess findings for cancers of the lung, nose/nasal sinuses, and nasopharynx [20].
• A clinicopathologic study of malignant lymphomas of the nose, paranasal sinuses, and hard palate, including cases of lethal midline granuloma [21].

Associations of Paranasal Sinuses with chemical compounds

• Therefore, the authors selected 41 patients, whose results at CT examinations demonstrated a variety of pathologic conditions of the paranasal sinuses, to undergo MR imaging both with and without the use of gadopentetate dimeglumine for contrast enhancement [3].
• Cholesterol granulomata were seen in four lesions removed from the paranasal sinuses [22].
• CONCLUSIONS: We have shown that nasal allergen challenge can produce radiological changes in the paranasal sinuses [23].
• One question posed by clinicians is what happens to large pieces of titanium in communication with the paranasal sinuses or nasal-oral-pharyngeal area [24].
• This benign bacterial and granulomatous lesion of the paranasal sinuses gave homogeneous low intensity on T2-weighted images and enhanced with gadolinium [25].

Gene context of Paranasal Sinuses

• CONCLUSION: VEGF is locally produced in paranasal sinuses as well as nasal mucosa and its production is increased in patients with CPS [26].
• We have encountered two cases of solitary fibrous tumors in the paranasal sinuses and report the clinicopathological findings including CD34 immunoreactivity [27].
• Primary tumor sites were: face NOS (18%), orbit/periorbital (16%), nasal cavity/nose (14%), lymph nodes (12%), paranasal sinuses (10%), parameningeal (10%), parotid gland (6%), neck (6%), infratemporal fossa/zygoma (2%), buccal mucosa (2%), palate (2%), and larynx (2%) [28].
• This is the first demonstration of HBD-1 and HBD-2 production in the paranasal sinuses [29].
• Hypoxia is associated with the production of VEGF by nasal fibroblasts and TNF-alpha and endotoxin may act synergistically to enhance VEGF production in paranasal sinuses under hypoxic condition [26].

Analytical, diagnostic and therapeutic context of Paranasal Sinuses

• The ability to identify surgical sinus disease using diagnostic nasal endoscopy and coronal CT scanning of the paranasal sinuses is studied prospectively [30].
• The paranasal sinuses before and after radiotherapy for nasopharyngeal carcinoma: a computed tomographic study [31].
• CONCLUSIONS: The VF position and atomizer spray were both effective in delivery of the dexamethasone drops to the paranasal sinuses [32].
• The concentrations of ciprofloxacin and ofloxacin in tonsillar tissue and the concentrations of ofloxacin in the mucosa of the paranasal sinuses generally exceeded the peak concentrations of these agents in serum after oral administration of the drugs [33].
• CT scanning of the paranasal sinuses: axial helical CT with reconstruction in the coronal direction versus coronal helical CT [34].

References