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MeSH Review

Mucociliary Clearance

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Disease relevance of Mucociliary Clearance


Psychiatry related information on Mucociliary Clearance


High impact information on Mucociliary Clearance


Chemical compound and disease context of Mucociliary Clearance


Biological context of Mucociliary Clearance


Anatomical context of Mucociliary Clearance


Associations of Mucociliary Clearance with chemical compounds


Gene context of Mucociliary Clearance

  • Regulation of cystic fibrosis transmembrane regulator (CFTR) and epithelial sodium channel (ENaC) in airway epithelia strongly influences the rate of mucociliary clearance (MCC) by determining the volume of airway surface liquid [32].
  • This is consistent with the proposition that NPY is an autonomic efferent inhibitory neurotransmitter regulating mucociliary transport [33].
  • The soluble form facilitates the protection and lubrication of epithelia by mucous gels composed of gel-forming mucins, as in the airway, where Muc4 is proposed to participate in mucociliary transport as a constituent of the periciliary fluid [34].
  • These results support the hypothesis that HNE and PE contribute to the delayed mucociliary clearance and epithelial damage that is observed in patients with chronic bronchial infection [35].
  • Together with their potent anti-inflammatory properties, the potentially enhanced airway mucociliary clearance from CFTR activation may have contributed to the efficacy of PDE4 inhibitors in COPD and asthmatic patients [36].

Analytical, diagnostic and therapeutic context of Mucociliary Clearance

  • By enhancing Cl- secretion onto and blocking Na+ absorption from the airway surface, treatment with aerosolized uridine 5'-triphosphate (UTP) plus amiloride may improve the rheology of airway secretions and enhance mucociliary clearance in patients with CF [37].
  • OBJECTIVE: This article summarizes recent literature about possible adverse biologic effects associated with BKC as a nasal spray preservative by examining its effects on the following properties of mucociliary transport: ciliary motion, ciliary form, ciliary beat frequency, electron microscopy, and particle movement/saccharin clearance tests [38].
  • CONCLUSION: Despite similar changes in FEV1 with the two formulations terbutaline increased mucociliary clearance significantly in asthmatic and healthy subjects when inhaled from a metered dose inhaler whereas when it was inhaled from a dry powder inhaler its effect was significant only in healthy subjects [39].
  • Central and peripheral pulmonary mucociliary clearance was assessed by tantalum bronchography and serial chest roentgenograms in dogs [40].
  • We have adapted a moving transmission line source to acquire dynamic geometric mean measurements in the study of the mucociliary clearance of inhaled technetium-99m labelled colloids with a single-headed rotating gamma camera [41].


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  2. Ecto 5'-nucleotidase and nonspecific alkaline phosphatase. Two AMP-hydrolyzing ectoenzymes with distinct roles in human airways. Picher, M., Burch, L.H., Hirsh, A.J., Spychala, J., Boucher, R.C. J. Biol. Chem. (2003) [Pubmed]
  3. Effect of rhDNase on airflow obstruction and mucociliary clearance in cystic fibrosis. Laube, B.L., Auci, R.M., Shields, D.E., Christiansen, D.H., Lucas, M.K., Fuchs, H.J., Rosenstein, B.J. Am. J. Respir. Crit. Care Med. (1996) [Pubmed]
  4. Restoration of mucociliary transport in the fluid-depleted trachea by surface-active instillates. Ballard, S.T., Parker, J.C., Hamm, C.R. Am. J. Respir. Cell Mol. Biol. (2006) [Pubmed]
  5. Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species. Fischer, B.M., Voynow, J.A. Am. J. Respir. Cell Mol. Biol. (2002) [Pubmed]
  6. Recovery of nasal physiology after functional endoscopic sinus surgery: olfaction and mucociliary transport. Min, Y.G., Yun, Y.S., Song, B.H., Cho, Y.S., Lee, K.S. ORL J. Otorhinolaryngol. Relat. Spec. (1995) [Pubmed]
  7. Measurement of nasal mucociliary clearance. Corbo, G.M., Foresi, A., Bonfitto, P., Mugnano, A., Agabiti, N., Cole, P.J. Arch. Dis. Child. (1989) [Pubmed]
  8. Role of CFTR in airway disease. Pilewski, J.M., Frizzell, R.A. Physiol. Rev. (1999) [Pubmed]
  9. Cyclic AMP-dependent protein kinase opens chloride channels in normal but not cystic fibrosis airway epithelium. Li, M., McCann, J.D., Liedtke, C.M., Nairn, A.C., Greengard, P., Welsh, M.J. Nature (1988) [Pubmed]
  10. Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility. Sakamoto, O., Iwama, A., Amitani, R., Takehara, T., Yamaguchi, N., Yamamoto, T., Masuyama, K., Yamanaka, T., Ando, M., Suda, T. J. Clin. Invest. (1997) [Pubmed]
  11. High frequency oscillations improve nasal mucociliary transport. George, R.J., Moore-Gillon, V., Geddes, D.M. Lancet (1984) [Pubmed]
  12. Long-term ipratropium bromide nebuliser therapy and lung mucociliary clearance. Pavia, D., Lopez-Vidriero, M.T., Sutton, P.P., Clarke, S.W. Lancet (1982) [Pubmed]
  13. Effect of amiloride and saline on nasal mucociliary clearance and potential difference in cystic fibrosis and normal subjects. Middleton, P.G., Geddes, D.M., Alton, E.W. Thorax (1993) [Pubmed]
  14. Effect of inhaled salbutamol on mucociliary clearance in patients with chronic bronchitis. Fazio, F., Lafortuna, C. Chest (1981) [Pubmed]
  15. Fluid transport by airway epithelia. Widdicombe, J.H. Biorheology. (1987) [Pubmed]
  16. Alterations of nasal mucociliary clearance in association with HIV infection and the effect of guaifenesin therapy. Rosen, E.J., Calhoun, K.H. Laryngoscope (2005) [Pubmed]
  17. Influence of clenbuterol on mucociliary transport in healthy horses and horses with chronic obstructive pulmonary disease. Turgut, K., Sasse, H.H. Vet. Rec. (1989) [Pubmed]
  18. Inhalation of dry powder mannitol improves clearance of mucus in patients with bronchiectasis. Daviskas, E., Anderson, S.D., Eberl, S., Chan, H.K., Bautovich, G. Am. J. Respir. Crit. Care Med. (1999) [Pubmed]
  19. Halothane inhibition of ion transport of the tracheal epithelium. A possible mechanism for anesthetic-induced impairment of mucociliary clearance. Pizov, R., Takahashi, M., Hirshman, C.A., Croxton, T. Anesthesiology (1992) [Pubmed]
  20. Contribution of formaldehyde to respiratory cancer. Nelson, N., Levine, R.J., Albert, R.E., Blair, A.E., Griesemer, R.A., Landrigan, P.J., Stayner, L.T., Swenberg, J.A. Environ. Health Perspect. (1986) [Pubmed]
  21. Nasal mucociliary transport: new evidence for a key role of ciliary beat frequency. Boek, W.M., Graamans, K., Natzijl, H., van Rijk, P.P., Huizing, E.H. Laryngoscope (2002) [Pubmed]
  22. Ipratropium bromide: mucociliary clearance rate and airway resistance in normal subjects. Francis, R.A., Thompson, M.L., Pavia, D., Douglas, R.B. British journal of diseases of the chest. (1977) [Pubmed]
  23. Absorption and distribution kinetics of the major Parietaria judaica allergen (Par j 1) administered by noninjectable routes in healthy human beings. Bagnasco, M., Mariani, G., Passalacqua, G., Motta, C., Bartolomei, M., Falagiani, P., Mistrello, G., Canonica, G.W. J. Allergy Clin. Immunol. (1997) [Pubmed]
  24. Endothelin-1 depresses tracheal mucus velocity in ovine airways via ET-A receptors. Sabater, J.R., Otero, R., Abraham, W.M., Wanner, A., O'Riordan, T.G. Am. J. Respir. Crit. Care Med. (1996) [Pubmed]
  25. Acute effect of inhaled bradykinin on tracheobronchial clearance in normal humans. Polosa, R., Hasani, A., Pavia, D., Agnew, J.E., Lai, C.K., Clarke, S.W., Holgate, S.T. Thorax (1992) [Pubmed]
  26. Biochemical evidence for an ecto alkaline phosphodiesterase I in human airways. Picher, M., Boucher, R.C. Am. J. Respir. Cell Mol. Biol. (2000) [Pubmed]
  27. Effect of four weeks' high dose ipratropium bromide treatment on lung mucociliary clearance. Taylor, R.G., Pavia, D., Agnew, J.E., Lopez-Vidriero, M.T., Newman, S.P., Lennard-Jones, T., Clarke, S.W. Thorax (1986) [Pubmed]
  28. Human airway ecto-adenylate kinase. A mechanism to propagate ATP signaling on airway surfaces. Picher, M., Boucher, R.C. J. Biol. Chem. (2003) [Pubmed]
  29. How much theophylline is enough? Fairshter, R.D. Am. J. Med. (1988) [Pubmed]
  30. Ozone-induced impairment of mucociliary transport and its prevention with N-acetylcysteine. Allegra, L., Moavero, N.E., Rampoldi, C. Am. J. Med. (1991) [Pubmed]
  31. Acute safety and effects on mucociliary clearance of aerosolized uridine 5'-triphosphate +/- amiloride in normal human adults. Olivier, K.N., Bennett, W.D., Hohneker, K.W., Zeman, K.L., Edwards, L.J., Boucher, R.C., Knowles, M.R. Am. J. Respir. Crit. Care Med. (1996) [Pubmed]
  32. Local regulation of cystic fibrosis transmembrane regulator and epithelial sodium channel in airway epithelium. Huang, P., Gilmore, E., Kultgen, P., Barnes, P., Milgram, S., Stutts, M.J. Proceedings of the American Thoracic Society. (2004) [Pubmed]
  33. Neuropeptide Y inhibits ciliary beat frequency in human ciliated cells via nPKC, independently of PKA. Wong, L.B., Park, C.L., Yeates, D.B. Am. J. Physiol. (1998) [Pubmed]
  34. Muc4/sialomucin complex, the intramembrane ErbB2 ligand, in cancer and epithelia: to protect and to survive. Carraway, K.L., Perez, A., Idris, N., Jepson, S., Arango, M., Komatsu, M., Haq, B., Price-Schiavi, S.A., Zhang, J., Carraway, C.A. Prog. Nucleic Acid Res. Mol. Biol. (2002) [Pubmed]
  35. Effects of human neutrophil elastase and Pseudomonas aeruginosa proteinases on human respiratory epithelium. Amitani, R., Wilson, R., Rutman, A., Read, R., Ward, C., Burnett, D., Stockley, R.A., Cole, P.J. Am. J. Respir. Cell Mol. Biol. (1991) [Pubmed]
  36. Dynamic activation of cystic fibrosis transmembrane conductance regulator by type 3 and type 4D phosphodiesterase inhibitors. Liu, S., Veilleux, A., Zhang, L., Young, A., Kwok, E., Laliberté, F., Chung, C., Tota, M.R., Dubé, D., Friesen, R.W., Huang, Z. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  37. Effect of uridine 5'-triphosphate plus amiloride on mucociliary clearance in adult cystic fibrosis. Bennett, W.D., Olivier, K.N., Zeman, K.L., Hohneker, K.W., Boucher, R.C., Knowles, M.R. Am. J. Respir. Crit. Care Med. (1996) [Pubmed]
  38. Is the use of benzalkonium chloride as a preservative for nasal formulations a safety concern? A cautionary note based on compromised mucociliary transport. Bernstein, I.L. J. Allergy Clin. Immunol. (2000) [Pubmed]
  39. Effect of terbutaline on mucociliary clearance in asthmatic and healthy subjects after inhalation from a pressurised inhaler and a dry powder inhaler. Mortensen, J., Groth, S., Lange, P., Hermansen, F. Thorax (1991) [Pubmed]
  40. Mucociliary clearance in the canine lung during and after general anesthesia. Forbes, A.R., Gamsu, G. Anesthesiology (1979) [Pubmed]
  41. Simultaneous emission and transmission measurements as an adjunct to dynamic planar gamma camera studies. Bailey, D.L., Robinson, M., Meikle, S.R., Bye, P.T. European journal of nuclear medicine. (1996) [Pubmed]
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