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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Brinkmann, V. et al.

Brinkmann, Lynch,

FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity.

The novel immunomodulator FTY720 is remarkably effective in models of transplantation and autoimmunity. Recent data show that phosphorylated FTY720 is an agonist at four sphingosine 1-phosphate receptors. Stimulation of sphingosine 1-phosphate receptors leads to sequestration of lymphocytes in secondary lymphatic tissues and thus away from inflammatory lesions and graft sites.[1]

References

FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity. Brinkmann, V., Lynch, K.R. Curr. Opin. Immunol. (2002) [Pubmed]

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