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Yun, H.J. et al.

In vitro and in vivo antibacterial activities of DW286, a new fluoronaphthyridone antibiotic.

The in vitro and in vivo activities of DW286, a novel fluoronaphthyridone with potent antibacterial activity, were compared with those of ciprofloxacin, gemifloxacin, sparfloxacin, and trovafloxacin. Against gram-positive bacteria, such as Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, and Enterococcus faecalis, the in vitro activity of DW286 was stronger than that of any other reference antibiotic. Against gram-negative bacteria, the activity of DW286 was similar to those of trovafloxacin and gemifloxacin but was weaker than that of ciprofloxacin. In a mouse systemic infection caused by three S. aureus strains, including methicillin-resistant S. aureus and quinolone-resistant S. aureus (QRSA), DW286 demonstrated the most potent activity, as found in vitro. Specially, DW286 is >or=8-fold more active against QRSA than the other fluoroquinolones. And the 50% protective doses for DW286 were correspondent with the in vitro activities.[1]

References

In vitro and in vivo antibacterial activities of DW286, a new fluoronaphthyridone antibiotic. Yun, H.J., Min, Y.H., Lim, J.A., Kang, J.W., Kim, S.Y., Kim, M.J., Jeong, J.H., Choi, Y.J., Kwon, H.J., Jung, Y.H., Shim, M.J., Choi, E.C. Antimicrob. Agents Chemother. (2002) [Pubmed]

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