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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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OcaB is required for normal transcription and V(D)J recombination of a subset of immunoglobulin kappa genes.

OcaB, a transcriptional coactivator also known as Bob-1 or OBF-1, was isolated on the basis of its ability to enhance transcription of immunoglobulin (Ig) genes in vitro. Paradoxically, OcaB(-/-) mice showed no apparent deficiency in Ig gene transcription, only cellular immune defects including absence of germinal centers (GC) and decreased numbers of immature B cells; the genes targeted by OcaB were not determined. Here we report that OcaB is essential for V(D)J recombination of a subset of Igkappa genes. We show that OcaB modulates recombination by directly enhancing Igkappa gene transcription in vivo.[1]

References

  1. OcaB is required for normal transcription and V(D)J recombination of a subset of immunoglobulin kappa genes. Casellas, R., Jankovic, M., Meyer, G., Gazumyan, A., Luo, Y., Roeder, R., Nussenzweig, M. Cell (2002) [Pubmed]
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