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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A role of heparin-binding epidermal growth factor-like growth factor in cardiac remodeling after myocardial infarction.

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is known to induce cell growth in various cell types via transactivation of epidermal growth factor receptor (EGFR). To investigate the involvement of HB-EGF and EGFR in cardiac remodeling after myocardial infarction (MI), we examined the expressions of mRNA and protein in rat hearts 6 weeks after MI-induction. Where increased expressions of HB-EGF mRNA and protein were observed, infarcted myocardium was replaced by extracellular matrix and interstitial fibroblasts. EGFR mRNA and protein expression did not show significant changes in sham-operated heart tissues, non-infarcted region, and infarcted region. In vitro study demonstrated that HB-EGF mRNA was expressed mainly in cultured fibroblasts rather than in myocytes. We suggest that the interaction between HB-EGF and EGFR transactivation is closely related to the proliferation of cardiac fibroblasts and cardiac remodeling after MI in an autocrine, paracrine, and juxtacrine manner.[1]

References

  1. A role of heparin-binding epidermal growth factor-like growth factor in cardiac remodeling after myocardial infarction. Tanaka, N., Masamura, K., Yoshida, M., Kato, M., Kawai, Y., Miyamori, I. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
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