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Gene Review

Egf  -  epidermal growth factor

Rattus norvegicus

Synonyms: EGF, Pro-epidermal growth factor
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Disease relevance of Egf

  • In Rat 1 fibroblasts, stimulation of mitogen-activated protein (MAP) kinase via the IGF1 receptor and the Gi-coupled receptor for lysophosphatidic acid (LPA), but not via the EGF receptor, is sensitive both to pertussis toxin treatment and to cellular expression of a specific G beta gamma subunit-binding peptide [1].
  • These findings suggest that the neurotrophic activity of EGF is maintained by afferent signals of midbrain dopaminergic neurons and is impaired in patients with Parkinson's disease [2].
  • A rat pheochromocytoma cell line (PC12), when transfected with beta1,4-N-acetylglucosaminyltransferase III (GnT-III), which catalyzes the formation of a bisecting GlcNAc structure in N-glycans, resulted in the suppression of neurite outgrowth induced by costimulation of epidermal growth factor (EGF) and integrins [3].
  • CONCLUSIONS: Because most breast carcinomas overexpress c-Src, it behooves one to question the extent to which reducing the amount of EGF and consequent EGFR activity will decrease invasion [4].
  • Instead, our results indicate that in BT474 breast carcinoma cells, EGF can substitute for c-Src in promoting breast cancer cell invasion [4].

Psychiatry related information on Egf


High impact information on Egf


Chemical compound and disease context of Egf


Biological context of Egf


Anatomical context of Egf


Associations of Egf with chemical compounds


Physical interactions of Egf


Enzymatic interactions of Egf


Regulatory relationships of Egf


Other interactions of Egf


Analytical, diagnostic and therapeutic context of Egf


  1. G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor. Luttrell, L.M., van Biesen, T., Hawes, B.E., Koch, W.J., Touhara, K., Lefkowitz, R.J. J. Biol. Chem. (1995) [Pubmed]
  2. Influences of dopaminergic lesion on epidermal growth factor-ErbB signals in Parkinson's disease and its model: neurotrophic implication in nigrostriatal neurons. Iwakura, Y., Piao, Y.S., Mizuno, M., Takei, N., Kakita, A., Takahashi, H., Nawa, H. J. Neurochem. (2005) [Pubmed]
  3. Beta1,4-N-Acetylglucosaminyltransferase III down-regulates neurite outgrowth induced by costimulation of epidermal growth factor and integrins through the Ras/ERK signaling pathway in PC12 cells. Gu, J., Zhao, Y., Isaji, T., Shibukawa, Y., Ihara, H., Takahashi, M., Ikeda, Y., Miyoshi, E., Honke, K., Taniguchi, N. Glycobiology (2004) [Pubmed]
  4. Epidermal growth factor stimulation can substitute for c-Src overexpression in promoting breast carcinoma invasion. Lotz, M., Wang, H.H., Cance, W., Matthews, J., Pories, S. J. Surg. Res. (2003) [Pubmed]
  5. Oxidative stress differentially modulates phosphorylation of ERK, p38 and CREB induced by NGF or EGF in PC12 cells. Zhang, L., Jope, R.S. Neurobiol. Aging (1999) [Pubmed]
  6. Neuritogenesis induced by thyroid hormone-treated astrocytes is mediated by epidermal growth factor/mitogen-activated protein kinase-phosphatidylinositol 3-kinase pathways and involves modulation of extracellular matrix proteins. Martinez, R., Gomes, F.C. J. Biol. Chem. (2002) [Pubmed]
  7. Conditioned place preference and locomotor sensitization after repeated administration of cocaine or methamphetamine in rats treated with epidermal growth factor during the neonatal period. Mizuno, M., Malta, R.S., Nagano, T., Nawa, H. Ann. N. Y. Acad. Sci. (2004) [Pubmed]
  8. Chronic ethanol feeding alters the structure and function of the epidermal growth factor receptor in rat stomach. Wang, S.L., Wu-Wang, C.Y., Feng, J., Espina, N., Garro, A.J. Alcohol (1996) [Pubmed]
  9. Characterization of signaling pathways to Na+/H+ exchanger activation with epidermal growth factor in hepatocytes. Tanaka, Y., Hayashi, N., Kaneko, A., Ito, T., Horimoto, M., Sasaki, Y., Kasahara, A., Fusamoto, H., Kamada, T. Hepatology (1994) [Pubmed]
  10. EGF receptor affinity is regulated by intracellular calcium and protein kinase C. Fearn, J.C., King, A.C. Cell (1985) [Pubmed]
  11. Transforming growth factor-beta controls receptor levels for epidermal growth factor in NRK fibroblasts. Assoian, R.K., Frolik, C.A., Roberts, A.B., Miller, D.M., Sporn, M.B. Cell (1984) [Pubmed]
  12. Activation of p42/p44 mitogen-activated protein kinase by angiotensin II, vasopressin, norepinephrine, and prostaglandin F2alpha in hepatocytes is sustained, and like the effect of epidermal growth factor, mediated through pertussis toxin-sensitive mechanisms. Melien, O., Thoresen, G.H., Sandnes, D., Ostby, E., Christoffersen, T. J. Cell. Physiol. (1998) [Pubmed]
  13. Saccharin induces morphological changes and enhances prolactin production in GH4C1 cells. Brennessel, B.A., Keyes, K.J. In Vitro Cell. Dev. Biol. (1985) [Pubmed]
  14. Epidermal growth factor decreases thyroid hormone receptors and attenuates thyroid hormone responses in GH4C1 cells. Kaji, H., Hinkle, P.M. Endocrinology (1987) [Pubmed]
  15. Human pancreatic cancer cell lines do not express receptors for somatostatin. Gillespie, J., Poston, G.J., Schachter, M., Guillou, P.J. Br. J. Cancer (1992) [Pubmed]
  16. Epidermal growth factor reduces L-type voltage-activated calcium current density in GH4C1 rat pituitary cells. Fu, J., Scammell, J.G., Li, M. Neuroendocrinology (1997) [Pubmed]
  17. Insulin-like growth factor I gene expression in isolated rat renal collecting duct is stimulated by epidermal growth factor. Rogers, S.A., Miller, S.B., Hammerman, M.R. J. Clin. Invest. (1991) [Pubmed]
  18. Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways. Burgering, B.M., de Vries-Smits, A.M., Medema, R.H., van Weeren, P.C., Tertoolen, L.G., Bos, J.L. Mol. Cell. Biol. (1993) [Pubmed]
  19. Tumor promoter arsenite activates extracellular signal-regulated kinase through a signaling pathway mediated by epidermal growth factor receptor and Shc. Chen, W., Martindale, J.L., Holbrook, N.J., Liu, Y. Mol. Cell. Biol. (1998) [Pubmed]
  20. Phospholipase D and RalA cooperate with the epidermal growth factor receptor to transform 3Y1 rat fibroblasts. Lu, Z., Hornia, A., Joseph, T., Sukezane, T., Frankel, P., Zhong, M., Bychenok, S., Xu, L., Feig, L.A., Foster, D.A. Mol. Cell. Biol. (2000) [Pubmed]
  21. The role of protein kinase B and mitogen-activated protein kinase in epidermal growth factor and tumor necrosis factor alpha-mediated rat hepatocyte survival and apoptosis. Roberts, R.A., James, N.H., Cosulich, S.C. Hepatology (2000) [Pubmed]
  22. Induction of mitogen-activated protein kinase signal transduction pathway during gastric ulcer healing in rats. Pai, R., Ohta, M., Itani, R.M., Sarfeh, I.J., Tarnawski, A.S. Gastroenterology (1998) [Pubmed]
  23. Epidermal growth factor-induced activation of the insulin-like growth factor I receptor in rat hepatocytes. Hallak, H., Moehren, G., Tang, J., Kaou, M., Addas, M., Hoek, J.B., Rubin, R. Hepatology (2002) [Pubmed]
  24. Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells. Kao , S., Jaiswal, R.K., Kolch, W., Landreth, G.E. J. Biol. Chem. (2001) [Pubmed]
  25. Thyrotropin releasing hormone action in pituitary cells. Protein kinase C-mediated effects on the epidermal growth factor receptor. Kaji, H., Casnellie, J.E., Hinkle, P.M. J. Biol. Chem. (1988) [Pubmed]
  26. 5-HT2A receptor induces ERK phosphorylation and proliferation through ADAM-17 tumor necrosis factor-alpha-converting enzyme (TACE) activation and heparin-bound epidermal growth factor-like growth factor (HB-EGF) shedding in mesangial cells. Göoz, M., Göoz, P., Luttrell, L.M., Raymond, J.R. J. Biol. Chem. (2006) [Pubmed]
  27. Gene 33 is an endogenous inhibitor of epidermal growth factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF function. Xu, D., Makkinje, A., Kyriakis, J.M. J. Biol. Chem. (2005) [Pubmed]
  28. Effect of epidermal growth factor on placental amino acid transport and regulation of epidermal growth factor receptor expression of hepatocyte in rat. Masuyama, H., Hiramatsu, Y., Kudo, T. Journal of perinatal medicine. (1996) [Pubmed]
  29. Epidermal growth factor-mediated activation of the ETS domain transcription factor Elk-1 requires nuclear calcium. Pusl, T., Wu, J.J., Zimmerman, T.L., Zhang, L., Ehrlich, B.E., Berchtold, M.W., Hoek, J.B., Karpen, S.J., Nathanson, M.H., Bennett, A.M. J. Biol. Chem. (2002) [Pubmed]
  30. TAS-301, an inhibitor of smooth muscle cell migration and proliferation, inhibits intimal thickening after balloon injury to rat carotid arteries. Muranaka, Y., Yamasaki, Y., Nozawa, Y., Terakawa, H., Tanahashi, Y., Oda, N., Satoh, A., Asao, T., Miyake, H., Matsuura, N. J. Pharmacol. Exp. Ther. (1998) [Pubmed]
  31. Transforming growth factor receptors in liver regeneration following partial hepatectomy in the rat. Gruppuso, P.A., Mead, J.E., Fausto, N. Cancer Res. (1990) [Pubmed]
  32. Angiotensin AT(1) and AT(2) receptors differentially regulate angiopoietin-2 and vascular endothelial growth factor expression and angiogenesis by modulating heparin binding-epidermal growth factor (EGF)-mediated EGF receptor transactivation. Fujiyama, S., Matsubara, H., Nozawa, Y., Maruyama, K., Mori, Y., Tsutsumi, Y., Masaki, H., Uchiyama, Y., Koyama, Y., Nose, A., Iba, O., Tateishi, E., Ogata, N., Jyo, N., Higashiyama, S., Iwasaka, T. Circ. Res. (2001) [Pubmed]
  33. Thyrotropin-releasing hormone stimulates MAP kinase activity in GH3 cells by divergent pathways. Evidence of a role for early tyrosine phosphorylation. Ohmichi, M., Sawada, T., Kanda, Y., Koike, K., Hirota, K., Miyake, A., Saltiel, A.R. J. Biol. Chem. (1994) [Pubmed]
  34. An activated S6 kinase in extracts from serum- and epidermal growth factor-stimulated Swiss 3T3 cells. Novak-Hofer, I., Thomas, G. J. Biol. Chem. (1984) [Pubmed]
  35. Quantification of rat hepatocyte transferrin receptors with poly- and monoclonal antibodies and protein A. Rudolph, J.R., Regoeczi, E., Southward, S. Histochemistry (1988) [Pubmed]
  36. Transformation by pp60src or stimulation of cells with epidermal growth factor induces the stable association of tyrosine-phosphorylated cellular proteins with GTPase-activating protein. Bouton, A.H., Kanner, S.B., Vines, R.R., Wang, H.C., Gibbs, J.B., Parsons, J.T. Mol. Cell. Biol. (1991) [Pubmed]
  37. Rat liver membranes contain a 120 kDa glycoprotein which serves as a substrate for the tyrosine kinases of the receptors for insulin and epidermal growth factor. Phillips, S.A., Perrotti, N., Taylor, S.I. FEBS Lett. (1987) [Pubmed]
  38. EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor. Traverse, S., Seedorf, K., Paterson, H., Marshall, C.J., Cohen, P., Ullrich, A. Curr. Biol. (1994) [Pubmed]
  39. The signaling pathway coupling epidermal growth factor receptors to activation of p21ras. Sasaoka, T., Langlois, W.J., Leitner, J.W., Draznin, B., Olefsky, J.M. J. Biol. Chem. (1994) [Pubmed]
  40. Age-related decline in mitogen-activated protein kinase activity in epidermal growth factor-stimulated rat hepatocytes. Liu, Y., Guyton, K.Z., Gorospe, M., Xu, Q., Kokkonen, G.C., Mock, Y.D., Roth, G.S., Holbrook, N.J. J. Biol. Chem. (1996) [Pubmed]
  41. Role of specific protein kinase C isozymes in mediating epidermal growth factor, thyrotropin-releasing hormone, and phorbol ester regulation of the rat prolactin promoter in GH4/GH4C1 pituitary cells. Pickett, C.A., Manning, N., Akita, Y., Gutierrez-Hartmann, A. Mol. Endocrinol. (2002) [Pubmed]
  42. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Kulik, G., Klippel, A., Weber, M.J. Mol. Cell. Biol. (1997) [Pubmed]
  43. Epidermal growth factor and thyrotropin-releasing hormone interact synergistically with calcium to regulate prolactin mRNA levels. White, B.A., Bancroft, F.C. J. Biol. Chem. (1983) [Pubmed]
  44. Vascular endothelial growth factor, platelet-derived growth factor, and insulin-like growth factor-1 promote rat aortic angiogenesis in vitro. Nicosia, R.F., Nicosia, S.V., Smith, M. Am. J. Pathol. (1994) [Pubmed]
  45. Age-dependent decline in mitogenic stimulation of hepatocytes. Reduced association between Shc and the epidermal growth factor receptor is coupled to decreased activation of Raf and extracellular signal-regulated kinases. Palmer, H.J., Tuzon, C.T., Paulson, K.E. J. Biol. Chem. (1999) [Pubmed]
  46. Epithelial growth factor-induced phosphorylation of caveolin 1 at tyrosine 14 stimulates caveolae formation in epithelial cells. Orlichenko, L., Huang, B., Krueger, E., McNiven, M.A. J. Biol. Chem. (2006) [Pubmed]
  47. Two distinct regulatory mechanisms of neurotransmitter release by phosphatidylinositol 3-kinase. Itakura, M., Yamamori, S., Kuwahara, R., Sekiguchi, M., Takahashi, M. J. Neurochem. (2005) [Pubmed]
  48. EGF receptor-mediated, c-Src-dependent, activation of Stat5b is downregulated in mitogenically responsive hepatocytes. Guren, T.K., Ødegård, J., Abrahamsen, H., Thoresen, G.H., Susa, M., Andersson, Y., Østby, E., Christoffersen, T. J. Cell. Physiol. (2003) [Pubmed]
  49. Effects of growth factors on phosphatidylinositol-3 kinase in astroglial cells. Pomerance, M., Gavaret, J.M., Breton, M., Pierre, M. J. Neurosci. Res. (1995) [Pubmed]
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