The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

An IL-4-independent and CD25- mediated function of c-maf in promoting the production of Th2 cytokines.

c-maf is a T helper (Th)2 cell-specific transcription factor, which promotes the differentiation of Th2 cells mainly by an IL-4-dependent mechanism. It remains unclear whether c-maf possesses any IL-4-independent function in regulating the production of Th2 cytokines. Here, we provide evidence demonstrating that c-maf, independent of IL-4, is essential for normal induction of CD25 in developing Th2 cells. The levels of CD25 are significantly higher in developing Th2 cells than in developing Th1 cells during in vitro differentiation. In addition, timely blockade of IL-2 receptor signaling selectively inhibits the production of Th2 cytokines, but not IFN-gamma or IL-2. Taken together, our results uncover an IL-4-independent and CD25- mediated function of c-maf in promoting the production of Th2 cytokines.[1]

References

  1. An IL-4-independent and CD25-mediated function of c-maf in promoting the production of Th2 cytokines. Hwang, E.S., White, I.A., Ho, I.C. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
 
WikiGenes - Universities