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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Immunohistochemical localization of cyclooxygenase-2 in radicular cysts.

AIM: The purpose of this study was to investigate the expression of cyclooxygenase-2 ( COX-2) in radicular cysts. METHODOLOGY: Thirty biopsy specimens of radicular cysts were examined using immunohistochemistry. A peroxidase-labelled streptavidin-biotin technique was used for identification of the COX-2. Fisher's exact test (two-tail) was used for statistical analysis of the results. RESULTS: The result demonstrated that COX-2 expression was significantly higher in radicular cysts with higher levels of inflammatory infiltrates. COX-2 stain was detected in the lining epithelium, subepithelial fibroblasts, macrophages and endothelial cells in all specimens. CONCLUSIONS: COX-2 expression is significantly higher in radicular cysts. COX-2 may play an important role in the pathogenesis of radicular cysts.[1]

References

  1. Immunohistochemical localization of cyclooxygenase-2 in radicular cysts. Tsai, C.H., Huang, F.M., Yang, L.C., Chou, M.Y., Chang, Y.C. International endodontic journal. (2002) [Pubmed]
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