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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Rim and exocytosis: Rab3a-binding and secretion-enhancing domains are separate and function independently.

Rim1 has been identified in brain by its ability to bind Rab3a-GTP and has been postulated to be a Rab3a effector protein. Like Rabphilin3, another putative Rab3a effector protein, Rim1 modulates secretion and contains a zinc-finger and two C2 domains. We have investigated the structural basis for the ability of Rim1 to bind Rab3a-GTP and to stimulate exocytosis in chromaffin cells.[1]


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