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Schoonjans, K. et al.

Schoonjans, Annicotte, Huby, Botrugno, Fayard, Ueda, Chapman, Auwerx,

Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I.

The scavenger receptor class B type I ( SR-BI), which mediates selective cellular cholesterol uptake from high-density lipoproteins (HDLs), plays a key role in reverse cholesterol transport. The orphan nuclear receptor liver receptor homolog 1 ( LRH-1) and SR-BI are co-expressed in liver and ovary, suggesting that LRH-1 might control the expression of SR-BI in these tissues. LRH-1 induces human and mouse SR-BI promoter activity by binding to an LRH-1 response element in the promoter. Retroviral expression of LRH-1 robustly induces SR-BI, an effect associated with histone H3 acetylation on the SR-BI promoter. The decrease in SR-BI mRNA levels in livers of LRH-1(+/-) animals provides in vivo evidence that LRH-1 regulates SR-BI expression. Our data demonstrate that SR-BI is an LRH-1 target gene and underscore the pivotal role of LRH-1 in reverse cholesterol transport.[1]

References

Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I. Schoonjans, K., Annicotte, J.S., Huby, T., Botrugno, O.A., Fayard, E., Ueda, Y., Chapman, J., Auwerx, J. EMBO Rep. (2002) [Pubmed]

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