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Gene Review

Cxcl16  -  chemokine (C-X-C motif) ligand 16

Mus musculus

Synonyms: 0910001K24Rik, AV290116, BB024863, C-X-C motif chemokine 16, CXCL16v1, ...
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Disease relevance of Cxcl16


Psychiatry related information on Cxcl16


High impact information on Cxcl16


Chemical compound and disease context of Cxcl16


Biological context of Cxcl16

  • There was no effect on ScR mRNA abundance following LPS administration to LPS-resistant strains of mice, C3H/HeJ and IFN-gamma receptor-/-. The LPS-induced reduction in ScR mRNA in Swiss Webster mice was not sufficiently sustained to affect receptor function, as determined by the kinetics of [(125)I]-acetylated LDL clearance from plasma [16].
  • Therefore, this chemokine/scavenger receptor could serve as a molecular link between lipid metabolism and immune activity in the atherosclerotic lesion [17].
  • Influence of the cytocidal macrophage phenotype on the degradation of acetylated low density lipoproteins: dual regulation of scavenger receptor activity and of intracellular degradation of endocytosed ligand [18].
  • Increased susceptibility of thymocytes to apoptosis in mice lacking AIM, a novel murine macrophage-derived soluble factor belonging to the scavenger receptor cysteine-rich domain superfamily [19].
  • Transient transfection of the mouse macrophage cell line P388D1 with truncated scavenger receptor resulted in a 65% decrease in the uptake and degradation of Ac LDL but did not decrease the degradation of beta-migrating very low density lipoprotein, which is LDL receptor-mediated [20].

Anatomical context of Cxcl16


Associations of Cxcl16 with chemical compounds


Physical interactions of Cxcl16


Enzymatic interactions of Cxcl16


Regulatory relationships of Cxcl16


Other interactions of Cxcl16


Analytical, diagnostic and therapeutic context of Cxcl16


  1. Critical roles of CXC chemokine ligand 16/scavenger receptor that binds phosphatidylserine and oxidized lipoprotein in the pathogenesis of both acute and adoptive transfer experimental autoimmune encephalomyelitis. Fukumoto, N., Shimaoka, T., Fujimura, H., Sakoda, S., Tanaka, M., Kita, T., Yonehara, S. J. Immunol. (2004) [Pubmed]
  2. Molecular cloning of a novel scavenger receptor for oxidized low density lipoprotein, SR-PSOX, on macrophages. Shimaoka, T., Kume, N., Minami, M., Hayashida, K., Kataoka, H., Kita, T., Yonehara, S. J. Biol. Chem. (2000) [Pubmed]
  3. The scavenger receptor MARCO is required for lung defense against pneumococcal pneumonia and inhaled particles. Arredouani, M., Yang, Z., Ning, Y., Qin, G., Soininen, R., Tryggvason, K., Kobzik, L. J. Exp. Med. (2004) [Pubmed]
  4. Mannose-Binding Lectin Augments the Uptake of Lipid A, Staphylococcus aureus, and Escherichia coli by Kupffer Cells through Increased Cell Surface Expression of Scavenger Receptor A. Ono, K., Nishitani, C., Mitsuzawa, H., Shimizu, T., Sano, H., Suzuki, H., Kodama, T., Fujii, N., Fukase, K., Hirata, K., Kuroki, Y. J. Immunol. (2006) [Pubmed]
  5. Elimination of the class A scavenger receptor does not affect amyloid plaque formation or neurodegeneration in transgenic mice expressing human amyloid protein precursors. Huang, F., Buttini, M., Wyss-Coray, T., McConlogue, L., Kodama, T., Pitas, R.E., Mucke, L. Am. J. Pathol. (1999) [Pubmed]
  6. Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor. Paresce, D.M., Ghosh, R.N., Maxfield, F.R. Neuron (1996) [Pubmed]
  7. Charting the fate of the "good cholesterol": identification and characterization of the high-density lipoprotein receptor SR-BI. Krieger, M. Annu. Rev. Biochem. (1999) [Pubmed]
  8. PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Tontonoz, P., Nagy, L., Alvarez, J.G., Thomazy, V.A., Evans, R.M. Cell (1998) [Pubmed]
  9. PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Chawla, A., Barak, Y., Nagy, L., Liao, D., Tontonoz, P., Evans, R.M. Nat. Med. (2001) [Pubmed]
  10. Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils. El Khoury, J., Hickman, S.E., Thomas, C.A., Cao, L., Silverstein, S.C., Loike, J.D. Nature (1996) [Pubmed]
  11. Recognition and plasma clearance of endotoxin by scavenger receptors. Hampton, R.Y., Golenbock, D.T., Penman, M., Krieger, M., Raetz, C.R. Nature (1991) [Pubmed]
  12. Inhibition of alpha-glucosidases I and II increases the cell surface expression of functional class A macrophage scavenger receptor (SR-A) by extending its half-life. Tian, G., Wilcockson, D., Perry, V.H., Rudd, P.M., Dwek, R.A., Platt, F.M., Platt, N. J. Biol. Chem. (2004) [Pubmed]
  13. Diverting intracellular trafficking of Salmonella to the lysosome through activation of the late endocytic Rab7 by intracellular delivery of muramyl dipeptide. Mukherjee, K., Parashuraman, S., Krishnamurthy, G., Majumdar, J., Yadav, A., Kumar, R., Basu, S.K., Mukhopadhyay, A. J. Cell. Sci. (2002) [Pubmed]
  14. Action of ciprofibrate in type IIb hyperlipoproteinemia: modulation of the atherogenic lipoprotein phenotype and stimulation of high-density lipoprotein-mediated cellular cholesterol efflux. Guerin, M., Le Goff, W., Frisdal, E., Schneider, S., Milosavljevic, D., Bruckert, E., Chapman, M.J. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  15. Soluble heparin proteoglycans released from stimulated mast cells induce uptake of low density lipoproteins by macrophages via scavenger receptor-mediated phagocytosis. Lindstedt, K.A., Kokkonen, J.O., Kovanen, P.T. J. Lipid Res. (1992) [Pubmed]
  16. Lipopolysaccharide decreases scavenger receptor mRNA in vivo. Roselaar, S.E., Daugherty, A. J. Interferon Cytokine Res. (1997) [Pubmed]
  17. CXCL16/SR-PSOX is an interferon-gamma-regulated chemokine and scavenger receptor expressed in atherosclerotic lesions. Wuttge, D.M., Zhou, X., Sheikine, Y., Wågsäter, D., Stemme, V., Hedin, U., Stemme, S., Hansson, G.K., Sirsjö, A. Arterioscler. Thromb. Vasc. Biol. (2004) [Pubmed]
  18. Influence of the cytocidal macrophage phenotype on the degradation of acetylated low density lipoproteins: dual regulation of scavenger receptor activity and of intracellular degradation of endocytosed ligand. De Whalley, C.V., Riches, D.W. Exp. Cell Res. (1991) [Pubmed]
  19. Increased susceptibility of thymocytes to apoptosis in mice lacking AIM, a novel murine macrophage-derived soluble factor belonging to the scavenger receptor cysteine-rich domain superfamily. Miyazaki, T., Hirokami, Y., Matsuhashi, N., Takatsuka, H., Naito, M. J. Exp. Med. (1999) [Pubmed]
  20. Dominant negative mutations of the scavenger receptor. Native receptor inactivation by expression of truncated variants. Dejager, S., Mietus-Snyder, M., Friera, A., Pitas, R.E. J. Clin. Invest. (1993) [Pubmed]
  21. Maleylated-BSA enhances production of nitric oxide from macrophages. Alford, P.B., Xue, Y., Thai, S.F., Shackelford, R.E. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  22. Cloning and expression of a mouse macrophage cDNA coding for a membrane glycoprotein of the scavenger receptor cysteine-rich domain family. Chicheportiche, Y., Vassalli, P. J. Biol. Chem. (1994) [Pubmed]
  23. Expression of many immunologically important genes in Mycobacterium tuberculosis-infected macrophages is independent of both TLR2 and TLR4 but dependent on IFN-alphabeta receptor and STAT1. Shi, S., Blumenthal, A., Hickey, C.M., Gandotra, S., Levy, D., Ehrt, S. J. Immunol. (2005) [Pubmed]
  24. Scavenger receptor-specific allergen delivery elicits IFN-gamma-dominated immunity and directs established TH2-dominated responses to a nonallergic phenotype. Bhatia, S., Mukhopadhyay, S., Jarman, E., Hall, G., George, A., Basu, S.K., Rath, S., Lamb, J.R., Bal, V. J. Allergy Clin. Immunol. (2002) [Pubmed]
  25. Scavenger receptor mRNAs in rat brain microglia are induced by kainic acid lesioning and by cytokines. Grewal, R.P., Yoshida, T., Finch, C.E., Morgan, T.E. Neuroreport (1997) [Pubmed]
  26. Type F scavenger receptor SREC-I interacts with advillin, a member of the gelsolin/villin family, and induces neurite-like outgrowth. Shibata, M., Ishii, J., Koizumi, H., Shibata, N., Dohmae, N., Takio, K., Adachi, H., Tsujimoto, M., Arai, H. J. Biol. Chem. (2004) [Pubmed]
  27. Lamellar lipoproteins uniquely contribute to hyperlipidemia in mice doubly deficient in apolipoprotein E and hepatic lipase. Bergeron, N., Kotite, L., Verges, M., Blanche, P., Hamilton, R.L., Krauss, R.M., Bensadoun, A., Havel, R.J. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  28. Binding of oligoguanylate to scavenger receptors is required for oligonucleotides to augment NK cell activity and induce IFN. Kimura, Y., Sonehara, K., Kuramoto, E., Makino, T., Yamamoto, S., Yamamoto, T., Kataoka, T., Tokunaga, T. J. Biochem. (1994) [Pubmed]
  29. A disintegrin and metalloproteinase 10-mediated cleavage and shedding regulates the cell surface expression of CXC chemokine ligand 16. Gough, P.J., Garton, K.J., Wille, P.T., Rychlewski, M., Dempsey, P.J., Raines, E.W. J. Immunol. (2004) [Pubmed]
  30. Metal-catalyzed oxidation of extracellular matrix increases macrophage nitric oxide generation. Mattana, J., Margiloff, L., Chaplia, L., Chow, A., Singhal, P.C. Kidney Int. (1998) [Pubmed]
  31. SREC-II, a new member of the scavenger receptor type F family, trans-interacts with SREC-I through its extracellular domain. Ishii, J., Adachi, H., Aoki, J., Koizumi, H., Tomita, S., Suzuki, T., Tsujimoto, M., Inoue, K., Arai, H. J. Biol. Chem. (2002) [Pubmed]
  32. Decreased atherosclerosis in heterozygous low density lipoprotein receptor-deficient mice expressing the scavenger receptor BI transgene. Arai, T., Wang, N., Bezouevski, M., Welch, C., Tall, A.R. J. Biol. Chem. (1999) [Pubmed]
  33. Stimulation of macrophage urokinase expression by polyanions is protein kinase C-dependent and requires protein and RNA synthesis. Falcone, D.J., McCaffrey, T.A., Vergilio, J.A. J. Biol. Chem. (1991) [Pubmed]
  34. Apolipoprotein AII enrichment of HDL enhances their affinity for class B type I scavenger receptor but inhibits specific cholesteryl ester uptake. Pilon, A., Briand, O., Lestavel, S., Copin, C., Majd, Z., Fruchart, J.C., Castro, G., Clavey, V. Arterioscler. Thromb. Vasc. Biol. (2000) [Pubmed]
  35. Increased inflammation in mice deficient for the chemokine decoy receptor D6. Martinez de la Torre, Y., Locati, M., Buracchi, C., Dupor, J., Cook, D.N., Bonecchi, R., Nebuloni, M., Rukavina, D., Vago, L., Vecchi, A., Lira, S.A., Mantovani, A. Eur. J. Immunol. (2005) [Pubmed]
  36. Regulation and functional involvement of macrophage scavenger receptor MARCO in clearance of bacteria in vivo. van der Laan, L.J., Döpp, E.A., Haworth, R., Pikkarainen, T., Kangas, M., Elomaa, O., Dijkstra, C.D., Gordon, S., Tryggvason, K., Kraal, G. J. Immunol. (1999) [Pubmed]
  37. Activation of the stem cell-derived tyrosine kinase/RON receptor tyrosine kinase by macrophage-stimulating protein results in the induction of arginase activity in murine peritoneal macrophages. Morrison, A.C., Correll, P.H. J. Immunol. (2002) [Pubmed]
  38. Oxidized low density lipoproteins alter macrophage lipid uptake, apoptosis, viability and nitric oxide synthesis. Yang, X., Galeano, N.F., Szabolcs, M., Sciacca, R.R., Cannon, P.J. J. Nutr. (1996) [Pubmed]
  39. Modulation of allergen-specific immune responses to the major shrimp allergen, tropomyosin, by specific targeting to scavenger receptors on macrophages. Rajagopal, D., Ganesh, K.A., Subba Rao, P.V. Int. Arch. Allergy Immunol. (2000) [Pubmed]
  40. Macrophage-targeted photodynamic therapy: scavenger receptor expression and activation state. Liu, Q., Hamblin, M.R. International journal of immunopathology and pharmacology. (2005) [Pubmed]
  41. Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation. Delneste, Y., Magistrelli, G., Gauchat, J., Haeuw, J., Aubry, J., Nakamura, K., Kawakami-Honda, N., Goetsch, L., Sawamura, T., Bonnefoy, J., Jeannin, P. Immunity (2002) [Pubmed]
  42. Changes in plasma membrane properties and phosphatidylcholine subspecies of insect Sf9 cells due to expression of scavenger receptor class B, type I, and CD36. Parathath, S., Connelly, M.A., Rieger, R.A., Klein, S.M., Abumrad, N.A., De La Llera-Moya, M., Iden, C.R., Rothblat, G.H., Williams, D.L. J. Biol. Chem. (2004) [Pubmed]
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