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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Swann, A.C. et al.

Swann, Pazzaglia, Nicholls, Dougherty, Moeller,

Impulsivity and phase of illness in bipolar disorder.

BACKGROUND: Impulsivity is prominent in bipolar disorder, but there is little quantitative information relating it to phase of illness. METHODS: We measured impulsivity in patients with bipolar disorder who had not met episode criteria for at least 6 months, patients who were manic, and healthy control subjects. Impulsivity was measured using the Barratt Impulsiveness Scale (BIS) and performance on the computerized Immediate Memory-Remote Memory Task (IMT-DMT), based on the Continuous Performance Test, which has been shown to reflect risk of impulsivity in other populations. RESULTS: BIS scores in euthymic and manic bipolar subjects were identical, and were significantly elevated compared to controls. Commission errors (impulsive responses) on the IMT-DMT were elevated in manic subjects but were identical to controls in euthymic subjects. Measures of impulsivity did not appear related to depressive symptoms. LIMITATIONS: The number of subjects was too small for detailed investigation of the role of comorbidities; subjects were receiving pharmacological treatments. CONCLUSIONS: Impulsivity has state- and trait-related aspects in bipolar disorder.[1]

References

Impulsivity and phase of illness in bipolar disorder. Swann, A.C., Pazzaglia, P., Nicholls, A., Dougherty, D.M., Moeller, F.G. Journal of affective disorders. (2003) [Pubmed]

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