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MeSH Review


 Paschou,  Feng,  Pakstis,  Speed,  DeMille,  Kidd,  Jaghori,  Kurlan,  Pauls,  Sandor,  Barr,  Kidd,  Castle,  Uyemura,  Rafi,  Akande,  Makinodan,  Cameron,  Abelson,  Young,  Giralt,  Thall,  Khouri,  Wang,  Braunschweig,  Ippolitti,  Claxton,  Donato,  Bruton,  Cohen,  Davis,  Andersson,  Anderlini,  Gajewski,  Kornblau,  Andreeff,  Przepiorka,  Ueno,  Molldrem,  Champlin,  Alessandrino,  Bernasconi,  Colombo,  Caldera,  Malcovati,  Troletti,  Vanelli,  Varettoni,  Montanari,  Lazzarino,  Hayward,  Manning,  Kaplan,  Wagner,  Greenfield,  Kuuliala,  Eberhardt,  Takala,  Kautiainen,  Repo,  Leirisalo-Repo,  Ukkola,  Santaniemi,  Russell,  Kornstein,  Shea,  McCullough,  Harrison,  Hirschfeld,  Keller,  Farrell,  Howes,  Bebbington,  Brugha,  Jenkins,  Lewis,  Marsden,  Taylor,  Meltzer,  Bachert,  Bousquet,  Canonica,  Durham,  Klimek,  Mullol,  Van Cauwenberge,  Van Hammée,  Schalekamp,  van Geest-Daalderop,  de Vries-Goldschmeding,  Conemans,  Bernsen Mj,  de Boer,  Kim,  Leventhal,  Kim,  Kim,  Cheon,  Yoo,  Kim,  Badner,  Cook,  Lynskey,  Glowinski,  Todorov,  Bucholz,  Madden,  Nelson,  Statham,  Martin,  Heath,  Biondo,  Parés,  Kreisler,  Ragué,  Fraccalvieri,  Ruiz,  Jaurrieta,  Paradiso,  Hermann,  Blumer,  Davies,  Robinson,  Young,  Breslau,  Fiellin,  O'Connor,  Chawarski,  Pakes,  Pantalon,  Schottenfeld,  McCarty,  Arnold,  Lamont,  Fisher,  Kuhn,  Taché,  Martinez,  Million,  Wang,  
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Disease relevance of Comorbidity


Psychiatry related information on Comorbidity


High impact information on Comorbidity

  • PATIENTS: Forty-seven opioid-dependent patients who had been receiving methadone maintenance therapy in an NTP without evidence of illicit drug use for 1 year and without significant untreated psychiatric comorbidity were randomized; 1 patient refused to participate after treatment assignment to NTP [11].
  • After adjusting for age, sex, race, socioeconomic status, disease duration, and severity of diabetes and comorbidities, insulin users had slightly more laboratory tests performed, 2.4 more outpatient visits per year, and almost 300 more fingersticks for home glucose testing per year compared with sulfonylurea users (all P<.01) [12].
  • CONCLUSION: Our findings support the use of erythromycin as recommended by the ATS guidelines for outpatients aged 60 years or younger with no comorbidity [13].
  • Comorbidity of mental disorders and nicotine dependence [14].
  • By Cox regression analysis, survival was independently predicted by older age, abnormal gamma-glutamyl transpeptidase (GGT) levels, and presence of medical comorbidities at baseline [15].

Chemical compound and disease context of Comorbidity


Biological context of Comorbidity


Anatomical context of Comorbidity

  • CONCLUSIONS: Depression, a common psychiatric comorbidity among patients with chronic temporal lobe epilepsy, seems to be undertreated and to have adverse effects on cognitive functioning [26].
  • The aim of this study was to investigate thiotepa (TT) and fludarabine (Fluda) as a preparative regimen for allogeneic peripheral stem cell transplant in patients not eligible for a standard myeloablative regimen due to comorbidities and/or poor performance status [27].
  • Other independent predictors of poor outcome determined by multivariate analysis included history of congestive heart failure, male gender, increased number of comorbidities, higher serum blood urea nitrogen, and lower serum sodium [28].
  • Preoperative and operative variables analyzed for each patient were gender, age, American Society of Anesthesiologists score, comorbidities, indication for surgery, etiology of the disease, presence and grade of peritonitis, preoperative creatinine, hematocrit, hemoglobin, and leukocyte count, need for preoperative and operative transfusion [29].
  • RESULTS: With increasing comorbidity (increase in CIRS score) in older adults, there is a proportional decrease in immune response (decrease in T cell proliferation and IL-12 production and increase in IL-10 production in response to PHA stimulation) [30].

Associations of Comorbidity with chemical compounds


Gene context of Comorbidity

  • CONCLUSION: The increased expression of HLA-DQ and IL-1alpha may indicate systemic endothelial activation in extra-articular RA, which could be of importance for cardiovascular comorbidity and mortality in such patients [34].
  • RESULTS: sE-selectin levels were associated with CRP level (p=0.012), WBC (p=0.037), active joint count (p=0.019), progression of joint destruction (p=0.038), and HAQ score at five years (p=0.021), but not with extra-articular symptoms or comorbidity [35].
  • Adiponectin: a link between excess adiposity and associated comorbidities [36]?
  • CRF subtype 1 receptors are involved in the colonic and anxiogenic responses to stress and may have clinical relevance in the comorbidity of anxiety/depression and irritable bowel syndrome [37].
  • ADHD not otherwise specified (NOS) was the most common subtype and comorbidity rates were low [38].

Analytical, diagnostic and therapeutic context of Comorbidity


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  2. Melphalan and purine analog-containing preparative regimens: reduced-intensity conditioning for patients with hematologic malignancies undergoing allogeneic progenitor cell transplantation. Giralt, S., Thall, P.F., Khouri, I., Wang, X., Braunschweig, I., Ippolitti, C., Claxton, D., Donato, M., Bruton, J., Cohen, A., Davis, M., Andersson, B.S., Anderlini, P., Gajewski, J., Kornblau, S., Andreeff, M., Przepiorka, D., Ueno, N.T., Molldrem, J., Champlin, R. Blood (2001) [Pubmed]
  3. The risk of cancer in users of statins. Graaf, M.R., Beiderbeck, A.B., Egberts, A.C., Richel, D.J., Guchelaar, H.J. J. Clin. Oncol. (2004) [Pubmed]
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  7. Cortisol and catecholamines in posttraumatic stress disorder: an epidemiologic community study. Young, E.A., Breslau, N. Arch. Gen. Psychiatry (2004) [Pubmed]
  8. The 4-year course of tic disorders in boys with attention-deficit/hyperactivity disorder. Spencer, T., Biederman, M., Coffey, B., Geller, D., Wilens, T., Faraone, S. Arch. Gen. Psychiatry (1999) [Pubmed]
  9. Major depressive disorder, suicidal ideation, and suicide attempt in twins discordant for cannabis dependence and early-onset cannabis use. Lynskey, M.T., Glowinski, A.L., Todorov, A.A., Bucholz, K.K., Madden, P.A., Nelson, E.C., Statham, D.J., Martin, N.G., Heath, A.C. Arch. Gen. Psychiatry (2004) [Pubmed]
  10. Indications of linkage and association of Gilles de la Tourette syndrome in two independent family samples: 17q25 is a putative susceptibility region. Paschou, P., Feng, Y., Pakstis, A.J., Speed, W.C., DeMille, M.M., Kidd, J.R., Jaghori, B., Kurlan, R., Pauls, D.L., Sandor, P., Barr, C.L., Kidd, K.K. Am. J. Hum. Genet. (2004) [Pubmed]
  11. Methadone maintenance in primary care: a randomized controlled trial. Fiellin, D.A., O'Connor, P.G., Chawarski, M., Pakes, J.P., Pantalon, M.V., Schottenfeld, R.S. JAMA (2001) [Pubmed]
  12. Starting insulin therapy in patients with type 2 diabetes: effectiveness, complications, and resource utilization. Hayward, R.A., Manning, W.G., Kaplan, S.H., Wagner, E.H., Greenfield, S. JAMA (1997) [Pubmed]
  13. Medical outcomes and antimicrobial costs with the use of the American Thoracic Society guidelines for outpatients with community-acquired pneumonia. Gleason, P.P., Kapoor, W.N., Stone, R.A., Lave, J.R., Obrosky, D.S., Schulz, R., Singer, D.E., Coley, C.M., Marrie, T.J., Fine, M.J. JAMA (1997) [Pubmed]
  14. Comorbidity of mental disorders and nicotine dependence. Hughes, J.R. JAMA (1991) [Pubmed]
  15. Natural history of chronic HBV carriers in northern Italy: morbidity and mortality after 30 years. Manno, M., Cammà, C., Schepis, F., Bassi, F., Gelmini, R., Giannini, F., Miselli, F., Grottola, A., Ferretti, I., Vecchi, C., De Palma, M., Villa, E. Gastroenterology (2004) [Pubmed]
  16. Alcohol abuse, substance abuse, and panic disorder. Cowley, D.S. Am. J. Med. (1992) [Pubmed]
  17. Low dopamine D(2) receptor binding potential in social phobia. Schneier, F.R., Liebowitz, M.R., Abi-Dargham, A., Zea-Ponce, Y., Lin, S.H., Laruelle, M. The American journal of psychiatry. (2000) [Pubmed]
  18. The quality of life of patients with life-threatening arrhythmias. Arteaga, W.J., Windle, J.R. Arch. Intern. Med. (1995) [Pubmed]
  19. Nicotine, alcohol and drug dependence and psychiatric comorbidity. Results of a national household survey. Farrell, M., Howes, S., Bebbington, P., Brugha, T., Jenkins, R., Lewis, G., Marsden, J., Taylor, C., Meltzer, H. The British journal of psychiatry : the journal of mental science. (2001) [Pubmed]
  20. Chronic depression and comorbid personality disorders: response to sertraline versus imipramine. Russell, J.M., Kornstein, S.G., Shea, M.T., McCullough, J.P., Harrison, W.M., Hirschfeld, R.M., Keller, M.B. The Journal of clinical psychiatry. (2003) [Pubmed]
  21. Acenocoumarol stabilization is delayed in CYP2C93 carriers. Schalekamp, T., van Geest-Daalderop, J.H., de Vries-Goldschmeding, H., Conemans, J., Bernsen Mj, M., de Boer, A. Clin. Pharmacol. Ther. (2004) [Pubmed]
  22. Anxious and depressive disorders and their comorbidity: effect on central nervous system noradrenergic function. Cameron, O.G., Abelson, J.L., Young, E.A. Biol. Psychiatry (2004) [Pubmed]
  23. Is the comorbidity of epilepsy and migraine due to a shared genetic susceptibility? Ottman, R., Lipton, R.B. Neurology (1996) [Pubmed]
  24. C-reactive protein and sleep-disordered breathing. Guilleminault, C., Kirisoglu, C., Ohayon, M.M. Sleep. (2004) [Pubmed]
  25. Contrasting metabolic effects of antihypertensive agents. Velliquette, R.A., Ernsberger, P. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  26. Impact of depressed mood on neuropsychological status in temporal lobe epilepsy. Paradiso, S., Hermann, B.P., Blumer, D., Davies, K., Robinson, R.G. J. Neurol. Neurosurg. Psychiatr. (2001) [Pubmed]
  27. Reduced-intensity conditioning regimen with thiotepa and fludarabine followed by allogeneic blood stem cell transplantation in haematological malignancies. Alessandrino, E.P., Bernasconi, P., Colombo, A.A., Caldera, D., Malcovati, L., Troletti, D., Vanelli, L., Varettoni, M., Montanari, F., Lazzarino, M. Bone Marrow Transplant. (2004) [Pubmed]
  28. Effect of angiotensin-converting enzyme inhibitor therapy on 30-day outcome in patient > or = 65 years of age with chronic congestive heart failure. Sueta, C.A., Schenck, A., Chowdhury, M., Hall, R., Simpson, R.J. Am. J. Cardiol. (2000) [Pubmed]
  29. Anastomotic dehiscence after resection and primary anastomosis in left-sided colonic emergencies. Biondo, S., Parés, D., Kreisler, E., Ragué, J.M., Fraccalvieri, D., Ruiz, A.G., Jaurrieta, E. Dis. Colon Rectum (2005) [Pubmed]
  30. Comorbidity is a better predictor of impaired immunity than chronological age in older adults. Castle, S.C., Uyemura, K., Rafi, A., Akande, O., Makinodan, T. Journal of the American Geriatrics Society. (2005) [Pubmed]
  31. Methotrexate effects in patients with rheumatoid arthritis with cardiovascular comorbidity. Landewé, R.B., van den Borne, B.E., Breedveld, F.C., Dijkmans, B.A. Lancet (2000) [Pubmed]
  32. Contrast of treatment-seeking and untreated cocaine abusers. Carroll, K.M., Rounsaville, B.J. Arch. Gen. Psychiatry (1992) [Pubmed]
  33. A double-blind, crossover comparison of methylphenidate and placebo in adults with childhood-onset attention-deficit hyperactivity disorder. Spencer, T., Wilens, T., Biederman, J., Faraone, S.V., Ablon, J.S., Lapey, K. Arch. Gen. Psychiatry (1995) [Pubmed]
  34. Increased endothelial expression of HLA-DQ and interleukin 1alpha in extra-articular rheumatoid arthritis. Results from immunohistochemical studies of skeletal muscle. Turesson, C., Englund, P., Jacobsson, L.T., Sturfelt, G., Truedsson, L., Nennesmo, I., Lundberg, I.E. Rheumatology (Oxford, England) (2001) [Pubmed]
  35. Circulating soluble E-selectin in early rheumatoid arthritis: a prospective five year study. Kuuliala, A., Eberhardt, K., Takala, A., Kautiainen, H., Repo, H., Leirisalo-Repo, M. Ann. Rheum. Dis. (2002) [Pubmed]
  36. Adiponectin: a link between excess adiposity and associated comorbidities? Ukkola, O., Santaniemi, M. J. Mol. Med. (2002) [Pubmed]
  37. Stress and the gastrointestinal tract III. Stress-related alterations of gut motor function: role of brain corticotropin-releasing factor receptors. Taché, Y., Martinez, V., Million, M., Wang, L. Am. J. Physiol. Gastrointest. Liver Physiol. (2001) [Pubmed]
  38. Family-based association study of DAT1 and DRD4 polymorphism in Korean children with ADHD. Kim, Y.S., Leventhal, B.L., Kim, S.J., Kim, B.N., Cheon, K.A., Yoo, H.J., Kim, S.J., Badner, J., Cook, E.H. Neurosci. Lett. (2005) [Pubmed]
  39. Atrial fibrillation and stroke prevention with warfarin in the long-term care setting. Gurwitz, J.H., Monette, J., Rochon, P.A., Eckler, M.A., Avorn, J. Arch. Intern. Med. (1997) [Pubmed]
  40. Optimizing outcomes in bariatric surgery: outpatient laparoscopic gastric bypass. McCarty, T.M., Arnold, D.T., Lamont, J.P., Fisher, T.L., Kuhn, J.A. Ann. Surg. (2005) [Pubmed]
  41. Nocturnal but not short hours quotidian hemodialysis requires an elevated dialysate calcium concentration. Al-Hejaili, F., Kortas, C., Leitch, R., Heidenheim, A.P., Clement, L., Nesrallah, G., Lindsay, R.M. J. Am. Soc. Nephrol. (2003) [Pubmed]
  42. Perioperative glycemic control and the risk of infectious complications in a cohort of adults with diabetes. Golden, S.H., Peart-Vigilance, C., Kao, W.H., Brancati, F.L. Diabetes Care (1999) [Pubmed]
  43. Levocetirizine improves quality of life and reduces costs in long-term management of persistent allergic rhinitis. Bachert, C., Bousquet, J., Canonica, G.W., Durham, S.R., Klimek, L., Mullol, J., Van Cauwenberge, P.B., Van Hammée, G. J. Allergy Clin. Immunol. (2004) [Pubmed]
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