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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Partial splenectomy in cystic fibrosis patients with hypersplenism.

We report three cystic fibrosis ( CF) patients with hypersplenism who underwent partial splenectomy. The postoperative course was uneventful in two patients; one patient developed a complication necessitating resection of the rest of the spleen. Haematological parameters improved and oesophageal varices regressed in all patients. On follow up, one patient showed a normal spleen, the other a normally functioning accessory spleen; the third patient again developed splenomegaly with hypersplenism. Partial splenectomy is a promising therapeutic option for CF patients with hypersplenism.[1]


  1. Partial splenectomy in cystic fibrosis patients with hypersplenism. Thalhammer, G.H., Eber, E., Uranüs, S., Pfeifer, J., Zach, M.S. Arch. Dis. Child. (2003) [Pubmed]
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