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MeSH Review

Varicose Veins

 
 
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Disease relevance of Varicose Veins

 

High impact information on Varicose Veins

 

Chemical compound and disease context of Varicose Veins

 

Biological context of Varicose Veins

 

Anatomical context of Varicose Veins

 

Gene context of Varicose Veins

  • TIMP-1 is increased in vein segments from patients with varices (DI 0.8 +/- 0.1 vs 0.2 +/- 0.05, P < .05) while MMP-2 levels were decreased (DI 1.5 +/- 0.3 vs 0.5 +/- 0.1, P < .05) [25].
  • Through its inhibitory action on acid-peptic secretion, somatostatin may also inhibit peptic digestion of the clot at the site of hemostasis on the varix itself [26].
  • In summary, the plasma endotoxin concentration and endotoxin-binding capacity of alpha 1-acid glycoprotein and transferrin were shown to have increased after bleeding from varices by this new method [27].
  • Decreased production of collagen Type III in cultured smooth muscle cells from varicose vein patients is due to a degradation by MMPs: possible implication of MMP-3 [28].
  • Although unit increases in t-PA and vWF were initially associated with a significantly increased risk of CVI in men, and both factors with an elevated risk of trunk varices in women, multiple adjustment for age, smoking status and body mass index reduced the odds ratios to non-significance [29].
  • The FOXC2 gene on 16q24 is mutated in lymphoedema distichiasis (LD), in which varicose veins (VV) are a common feature, data strongly suggest FOXC2 to be implicated in the development of VV in the general population. [30]
 

Analytical, diagnostic and therapeutic context of Varicose Veins

References

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  21. Deficiency of protein C in patients with portal vein thrombosis. Orozco, H., Guraieb, E., Takahashi, T., Garcia-Tsao, G., Hurtado, R., Anaya, R., Ruiz-Arguelles, G., Hernandez-Ortiz, J., Casillas, M.A., Guevara, L. Hepatology (1988) [Pubmed]
  22. Propranolol and haemodynamic response in cirrhosis. Bendtsen, F., Henriksen, J.H., Sørensen, T.I. J. Hepatol. (1991) [Pubmed]
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  24. Role of Rho kinase signalling in healthy and varicose human saphenous veins. Cario-Toumaniantz, C., Evellin, S., Maury, S., Baron, O., Pacaud, P., Loirand, G. Br. J. Pharmacol. (2002) [Pubmed]
  25. Tissue inhibitor of metalloproteinase-1 is increased in the saphenofemoral junction of patients with varices in the leg. Parra, J.R., Cambria, R.A., Hower, C.D., Dassow, M.S., Freischlag, J.A., Seabrook, G.R., Towne, J.B. J. Vasc. Surg. (1998) [Pubmed]
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  28. Decreased production of collagen Type III in cultured smooth muscle cells from varicose vein patients is due to a degradation by MMPs: possible implication of MMP-3. Sansilvestri-Morel, P., Rupin, A., Jullien, N.D., Lembrez, N., Mestries-Dubois, P., Fabiani, J.N., Verbeuren, T.J. J. Vasc. Res. (2005) [Pubmed]
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  30. Linkage to the FOXC2 region of chromosome 16 for varicose veins in otherwise healthy, unselected sibling pairs. Ng, M.Y., Andrew, T., Spector, T.D., Jeffery, S. J. Med. Genet. (2005) [Pubmed]
  31. Octreotide infusion or emergency sclerotherapy for variceal haemorrhage. Sung, J.J., Chung, S.C., Lai, C.W., Chan, F.K., Leung, J.W., Yung, M.Y., Kassianides, C., Li, A.K. Lancet (1993) [Pubmed]
  32. Prospective randomised study of effect of octreotide on rebleeding from oesophageal varices after endoscopic ligation. Sung, J.J., Chung, S.C., Yung, M.Y., Lai, C.W., Lau, J.Y., Lee, Y.T., Leung, V.K., Li, M.K., Li, A.K. Lancet (1995) [Pubmed]
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  34. Pharmacological constriction of the lower oesophageal sphincter: a simple method of arresting variceal haemorrhage. Hosking, S.W., Doss, W., el-Zeiny, H., Robinson, P., Barsoum, M.S., Johnson, A.G. Gut (1988) [Pubmed]
  35. Factors related to early mortality after transjugular intrahepatic portosystemic shunt for failed endoscopic therapy in acute variceal bleeding. Patch, D., Nikolopoulou, V., McCormick, A., Dick, R., Armonis, A., Wannamethee, G., Burroughs, A. J. Hepatol. (1998) [Pubmed]
 
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