The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Varicose Veins

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Varicose Veins


High impact information on Varicose Veins


Chemical compound and disease context of Varicose Veins


Biological context of Varicose Veins


Anatomical context of Varicose Veins


Gene context of Varicose Veins

  • TIMP-1 is increased in vein segments from patients with varices (DI 0.8 +/- 0.1 vs 0.2 +/- 0.05, P < .05) while MMP-2 levels were decreased (DI 1.5 +/- 0.3 vs 0.5 +/- 0.1, P < .05) [25].
  • Through its inhibitory action on acid-peptic secretion, somatostatin may also inhibit peptic digestion of the clot at the site of hemostasis on the varix itself [26].
  • In summary, the plasma endotoxin concentration and endotoxin-binding capacity of alpha 1-acid glycoprotein and transferrin were shown to have increased after bleeding from varices by this new method [27].
  • Decreased production of collagen Type III in cultured smooth muscle cells from varicose vein patients is due to a degradation by MMPs: possible implication of MMP-3 [28].
  • Although unit increases in t-PA and vWF were initially associated with a significantly increased risk of CVI in men, and both factors with an elevated risk of trunk varices in women, multiple adjustment for age, smoking status and body mass index reduced the odds ratios to non-significance [29].
  • The FOXC2 gene on 16q24 is mutated in lymphoedema distichiasis (LD), in which varicose veins (VV) are a common feature, data strongly suggest FOXC2 to be implicated in the development of VV in the general population. [30]

Analytical, diagnostic and therapeutic context of Varicose Veins


  1. Propranolol in the prevention of first upper gastrointestinal tract hemorrhage in patients with cirrhosis of the liver and esophageal varices. Pascal, J.P., Cales, P. N. Engl. J. Med. (1987) [Pubmed]
  2. Randomized study comparing banding and propranolol to prevent initial variceal hemorrhage in cirrhotics with high-risk esophageal varices. Jutabha, R., Jensen, D.M., Martin, P., Savides, T., Han, S.H., Gornbein, J. Gastroenterology (2005) [Pubmed]
  3. Portal and systemic effects of selective infusion of vasopressin into the superior mesenteric artery in cirrhotic patients. Millette, B., Huet, P.M., Lavoie, P., Viallet, A. Gastroenterology (1975) [Pubmed]
  4. Aspects of the natural history of gastrointestinal bleeding in cirrhosis and the effect of prednisone. Christensen, E., Fauerholdt, L., Schlichting, P., Juhl, E., Poulsen, H., Tygstrup, N. Gastroenterology (1981) [Pubmed]
  5. Development and early prognosis of esophageal varices in severe chronic active liver disease (CALD) treated with prednisone. Czaja, A.J., Wolf, A.M., Summerskill, W.H. Gastroenterology (1979) [Pubmed]
  6. A pathophysiologic, gastroenterologic, and radiologic approach to the management of gastric varices. Ryan, B.M., Stockbrugger, R.W., Ryan, J.M. Gastroenterology (2004) [Pubmed]
  7. Bacterial infection in the pathogenesis of variceal bleeding. Goulis, J., Patch, D., Burroughs, A.K. Lancet (1999) [Pubmed]
  8. "Salvage" transjugular intrahepatic portosystemic shunts: gastric fundal compared with esophageal variceal bleeding. Chau, T.N., Patch, D., Chan, Y.W., Nagral, A., Dick, R., Burroughs, A.K. Gastroenterology (1998) [Pubmed]
  9. Early administration of somatostatin and efficacy of sclerotherapy in acute oesophageal variceal bleeds: the European Acute Bleeding Oesophageal Variceal Episodes (ABOVE) randomised trial. Avgerinos, A., Nevens, F., Raptis, S., Fevery, J. Lancet (1997) [Pubmed]
  10. Randomised trial of nadolol alone or with isosorbide mononitrate for primary prophylaxis of variceal bleeding in cirrhosis. Gruppo-Triveneto per L'ipertensione portale (GTIP). Merkel, C., Marin, R., Enzo, E., Donada, C., Cavallarin, G., Torboli, P., Amodio, P., Sebastianelli, G., Sacerdoti, D., Felder, M., Mazzaro, C., Beltrame, P., Gatta, A. Lancet (1996) [Pubmed]
  11. Octreotide and bleeding oesophageal varices. O'Donnell, L.J., Farthing, M.J. Lancet (1989) [Pubmed]
  12. How the lower oesophageal sphincter affects submucosal oesophageal varices. Miskowiak, J. Lancet (1978) [Pubmed]
  13. Controlled trial of terlipressin ('Glypressin') versus vasopressin in the early treatment of oesophageal varices. Freeman, J.G., Cobden, I., Lishman, A.H., Record, C.O. Lancet (1982) [Pubmed]
  14. Fluorescein mixed with sclerosant improves the accuracy of endoscopic injection of oesophageal varices. Hine, K.R., Morris, D., Toghill, P., Dykes, P.W. Lancet (1984) [Pubmed]
  15. Propranolol versus sclerotherapy in preventing variceal rebleeding: a randomized controlled trial. Terés, J., Bosch, J., Bordas, J.M., Garcia Pagán, J.C., Feu, F., Cirera, I., Rodés, J. Gastroenterology (1993) [Pubmed]
  16. Which patients with primary biliary cirrhosis or primary sclerosing cholangitis should undergo endoscopic screening for oesophageal varices detection? Bressler, B., Pinto, R., El-Ashry, D., Heathcote, E.J. Gut (2005) [Pubmed]
  17. Reduction of transmural oesophageal variceal pressure by metoclopramide. Kleber, G., Sauerbruch, T., Fischer, G., Geigenberger, G., Paumgartner, G. J. Hepatol. (1991) [Pubmed]
  18. An endoscopic injection with N-butyl-2-cyanoacrylate used for colonic variceal bleeding: a case report and review of the literature. Chen, W.C., Hou, M.C., Lin, H.C., Chang, F.Y., Lee, S.D. Am. J. Gastroenterol. (2000) [Pubmed]
  19. Mechanism of the haemostatic effect of ethanolamine oleate in the injection sclerotherapy for oesophageal varices. Kang, J.H., Kambayashi, J., Sakon, M., Shiozaki, H., Ogawa, Y., Ohshiro, T., Mori, T. The British journal of surgery. (1987) [Pubmed]
  20. Downhill varices: report of a case 29 years after resection of a substernal thyroid gland. Sorokin, J.J., Levine, S.M., Moss, E.G., Biddle, C.M. Gastroenterology (1977) [Pubmed]
  21. Deficiency of protein C in patients with portal vein thrombosis. Orozco, H., Guraieb, E., Takahashi, T., Garcia-Tsao, G., Hurtado, R., Anaya, R., Ruiz-Arguelles, G., Hernandez-Ortiz, J., Casillas, M.A., Guevara, L. Hepatology (1988) [Pubmed]
  22. Propranolol and haemodynamic response in cirrhosis. Bendtsen, F., Henriksen, J.H., Sørensen, T.I. J. Hepatol. (1991) [Pubmed]
  23. Reappraisal of the oxygenation of blood in varicose veins. Scott, H.J., Cheatle, T.R., McMullin, G.M., Coleridge Smith, P.D., Scurr, J.H. The British journal of surgery. (1990) [Pubmed]
  24. Role of Rho kinase signalling in healthy and varicose human saphenous veins. Cario-Toumaniantz, C., Evellin, S., Maury, S., Baron, O., Pacaud, P., Loirand, G. Br. J. Pharmacol. (2002) [Pubmed]
  25. Tissue inhibitor of metalloproteinase-1 is increased in the saphenofemoral junction of patients with varices in the leg. Parra, J.R., Cambria, R.A., Hower, C.D., Dassow, M.S., Freischlag, J.A., Seabrook, G.R., Towne, J.B. J. Vasc. Surg. (1998) [Pubmed]
  26. Somatostatin for upper gastrointestinal hemorrhage and pancreatic surgery. A review of its pharmacology and safety. Scarpignato, C., Pelosini, I. Digestion (1999) [Pubmed]
  27. Plasma endotoxin concentration and endotoxin binding capacity of plasma acute phase proteins in cirrhotics with variceal bleeding: an analysis by new methods. Fukui, H., Matsumoto, M., Tsujita, S., Takaya, A., Kojima, H., Matsumura, M., Tsujii, T. J. Gastroenterol. Hepatol. (1994) [Pubmed]
  28. Decreased production of collagen Type III in cultured smooth muscle cells from varicose vein patients is due to a degradation by MMPs: possible implication of MMP-3. Sansilvestri-Morel, P., Rupin, A., Jullien, N.D., Lembrez, N., Mestries-Dubois, P., Fabiani, J.N., Verbeuren, T.J. J. Vasc. Res. (2005) [Pubmed]
  29. Haemostatic factors and risk of varicose veins and chronic venous insufficiency: Edinburgh Vein Study. Lee, A.J., Lowe, G.D., Rumley, A., Ruckley, C.V., Fowkes, F.G. Blood Coagul. Fibrinolysis (2000) [Pubmed]
  30. Linkage to the FOXC2 region of chromosome 16 for varicose veins in otherwise healthy, unselected sibling pairs. Ng, M.Y., Andrew, T., Spector, T.D., Jeffery, S. J. Med. Genet. (2005) [Pubmed]
  31. Octreotide infusion or emergency sclerotherapy for variceal haemorrhage. Sung, J.J., Chung, S.C., Lai, C.W., Chan, F.K., Leung, J.W., Yung, M.Y., Kassianides, C., Li, A.K. Lancet (1993) [Pubmed]
  32. Prospective randomised study of effect of octreotide on rebleeding from oesophageal varices after endoscopic ligation. Sung, J.J., Chung, S.C., Yung, M.Y., Lai, C.W., Lau, J.Y., Lee, Y.T., Leung, V.K., Li, M.K., Li, A.K. Lancet (1995) [Pubmed]
  33. Methotrexate (MTX) plus ursodeoxycholic acid (UDCA) in the treatment of primary biliary cirrhosis. Combes, B., Emerson, S.S., Flye, N.L., Munoz, S.J., Luketic, V.A., Mayo, M.J., McCashland, T.M., Zetterman, R.K., Peters, M.G., Di Bisceglie, A.M., Benner, K.G., Kowdley, K.V., Carithers, R.L., Rosoff, L., Garcia-Tsao, G., Boyer, J.L., Boyer, T.D., Martinez, E.J., Bass, N.M., Lake, J.R., Barnes, D.S., Bonacini, M., Lindsay, K.L., Mills, A.S., Markin, R.S., Rubin, R., West, A.B., Wheeler, D.E., Contos, M.J., Hofmann, A.F. Hepatology (2005) [Pubmed]
  34. Pharmacological constriction of the lower oesophageal sphincter: a simple method of arresting variceal haemorrhage. Hosking, S.W., Doss, W., el-Zeiny, H., Robinson, P., Barsoum, M.S., Johnson, A.G. Gut (1988) [Pubmed]
  35. Factors related to early mortality after transjugular intrahepatic portosystemic shunt for failed endoscopic therapy in acute variceal bleeding. Patch, D., Nikolopoulou, V., McCormick, A., Dick, R., Armonis, A., Wannamethee, G., Burroughs, A. J. Hepatol. (1998) [Pubmed]
WikiGenes - Universities