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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

PPARdelta is a very low-density lipoprotein sensor in macrophages.

Although triglyceride-rich particles, such as very low-density lipoprotein (VLDL), contribute significantly to human atherogenesis, the molecular basis for lipoprotein-driven pathogenicity is poorly understood. We demonstrate that in macrophages, VLDL functions as a transcriptional regulator via the activation of the nuclear receptor peroxisome proliferator-activated receptor delta. The signaling components of native VLDL are its triglycerides, whose activity is enhanced by lipoprotein lipase. Generation of peroxisome proliferator-activated receptor delta null macrophages verifies the absolute requirement of this transcription factor in mediating the VLDL response. Thus, our data reveal a pathway through which dietary triglycerides and VLDL can directly regulate gene expression in atherosclerotic lesions.[1]


  1. PPARdelta is a very low-density lipoprotein sensor in macrophages. Chawla, A., Lee, C.H., Barak, Y., He, W., Rosenfeld, J., Liao, D., Han, J., Kang, H., Evans, R.M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
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