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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Assessment in mice of the therapeutic potential of tailored, multivalent Shiga toxin carbohydrate ligands.

The therapeutic potential of 2 soluble multivalent receptor-based inhibitors of Shiga toxin ( Stx) 1 and Stx2 was determined in mice. One of these, Starfish, protected mice when it was injected subcutaneously in admixture with a lethal dose of Stx1 but not Stx2. Starfish also reduced the distribution of (125)I-Stx1 but not (125)I-Stx2 to the murine kidney and brain. A modified version of Starfish, called "Daisy," in which the Stx alpha Gal(1,4)beta Gal(1,4)beta Glc receptors were installed on the core glucose structure via a modified tethering strategy, protected mice against both Stx1 and Stx2. Daisy also protected streptomycin-treated mice from Escherichia coli O91:H21 and did not interfere with the ability of the murine immune system to produce Stx-specific protective antibodies. These results extend the possibility of using soluble carbohydrate-based receptor inhibitors to prevent Stx-mediated complications arising from infections with enterohemorrhagic E. coli serotypes.[1]

References

  1. Assessment in mice of the therapeutic potential of tailored, multivalent Shiga toxin carbohydrate ligands. Mulvey, G.L., Marcato, P., Kitov, P.I., Sadowska, J., Bundle, D.R., Armstrong, G.D. J. Infect. Dis. (2003) [Pubmed]
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