- The WFS1 gene, responsible for low frequency sensorineural hearing loss and Wolfram syndrome, is expressed in a variety of inner ear cells. Cryns, K., Thys, S., Van Laer, L., Oka, Y., Pfister, M., Van Nassauw, L., Smith, R.J., Timmermans, J.P., Van Camp, G. Histochem. Cell Biol. (2003)