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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Inhibition of PKCbeta improves glucocorticoid-induced insulin resistance in rat adipocytes.

Pretreatment with glucocorticoids for 60 min depressed insulin-stimulated uptake of 2-[3H] deoxyglucose (2-DOG), an effect that neither cycloheximide, an inhibitor of protein synthesis, nor RU38486, a glucocorticoid receptor antagonist, could restore. Preincubation with conventional PKC inhibitors restored dexamethasone-induced insulin resistance. We also examined the dexamethasone-mediated inhibitory effect on insulin-induced 2-DOG uptake in adipocytes overexpressed with wild-type and dominant negative forms of PKCbeta. The dexamethasone-mediated inhibitory effect on insulin-induced 2-DOG uptake was abrogated in adipocytes overexpressed with dominant-negative PKCbeta. These results indicate that PKCbeta may play an important role in glucocorticoid-induced insulin resistance.[1]

References

  1. Inhibition of PKCbeta improves glucocorticoid-induced insulin resistance in rat adipocytes. Kawai, Y., Ishizuka, T., Kajita, K., Miura, A., Ishizawa, M., Natsume, Y., Uno, Y., Morita, H., Yasuda, K. IUBMB Life (2002) [Pubmed]
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