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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

LIR-1 expression on lymphocytes, and cytomegalovirus disease in lung-transplant recipients.

Human cytomegalovirus infection is a major cause of morbidity after lung transplantation. LIR-1 (leucocyte immunoglobulin-like receptor-1) is an inhibitory cell surface receptor that has high affinity for an MHC class I homologue ( UL18) encoded by human cytomegalovirus. We aimed to investigate whether reactivation of human cytomegalovirus affects the expression of LIR-1. We measured LIR-1 expression on peripheral blood lymphocytes from 13 lung-transplant recipients and established human cytomegalovirus load using PCR. Eight patients developed cytomegalovirus disease. The percentage of cells expressing LIR-1 increased in the patients who developed cytomegalovirus disease several weeks before viral DNA was detectable by PCR. Measurement of LIR-1 expression might allow early identification of cytomegalovirus disease in lung-transplant patients.[1]


  1. LIR-1 expression on lymphocytes, and cytomegalovirus disease in lung-transplant recipients. Berg, L., Riise, G.C., Cosman, D., Bergström, T., Olofsson, S., Kärre, K., Carbone, E. Lancet (2003) [Pubmed]
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