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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Lung Transplantation

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Disease relevance of Lung Transplantation


Psychiatry related information on Lung Transplantation


High impact information on Lung Transplantation


Chemical compound and disease context of Lung Transplantation


Biological context of Lung Transplantation


Anatomical context of Lung Transplantation


Associations of Lung Transplantation with chemical compounds


Gene context of Lung Transplantation

  • We performed studies in a rat orthotopic lung transplantation model of acute rejection, and demonstrated increased expression of CXCL9 and CXCL10 paralleling the recruitment of mononuclear cells and cells expressing CXCR3 to the allograft [30].
  • We have demonstrated the importance of IL-8 in predicting early graft function after human lung transplantation [31].
  • Therapies directed at inhibition of innate immune responses mediated by TLR4 may represent a novel and effective means to prevent acute rejection after lung transplantation [32].
  • RESULTS: A significant correlation was detected between the presence of high-expression polymorphisms of the IL-6 and IFN-gamma genes and BOS development after lung transplantation (P =0.045 and 0.039, respectively) [33].
  • However, the activity of these newly synthesized NOS proteins remains suppressed during the ischemia-reperfusion period of lung transplantation [34].

Analytical, diagnostic and therapeutic context of Lung Transplantation


  1. BLT1-mediated T cell trafficking is critical for rejection and obliterative bronchiolitis after lung transplantation. Medoff, B.D., Seung, E., Wain, J.C., Means, T.K., Campanella, G.S., Islam, S.A., Thomas, S.Y., Ginns, L.C., Grabie, N., Lichtman, A.H., Tager, A.M., Luster, A.D. J. Exp. Med. (2005) [Pubmed]
  2. Hepatic glutamine synthetase deficiency in fatal hyperammonemia after lung transplantation. Tuchman, M., Lichtenstein, G.R., Rajagopal, B.S., McCann, M.T., Furth, E.E., Bavaria, J., Kaplan, P.B., Gibson, J.B., Berry, G.T. Ann. Intern. Med. (1997) [Pubmed]
  3. Failure to express the P-selectin gene or P-selectin blockade confers early pulmonary protection after lung ischemia or transplantation. Naka, Y., Toda, K., Kayano, K., Oz, M.C., Pinsky, D.J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  4. An elevated breathing reserve index at the lactate threshold is a predictor of mortality in patients with cystic fibrosis awaiting lung transplantation. Tantisira, K.G., Systrom, D.M., Ginns, L.C. Am. J. Respir. Crit. Care Med. (2002) [Pubmed]
  5. Transbronchial administration of adenoviral-mediated interleukin-10 gene to the donor improves function in a pig lung transplant model. Martins, S., de Perrot, M., Imai, Y., Yamane, M., Quadri, S.M., Segall, L., Dutly, A., Sakiyama, S., Chaparro, A., Davidson, B.L., Waddell, T.K., Liu, M., Keshavjee, S. Gene Ther. (2004) [Pubmed]
  6. Utilisation of medical technology assessment in health policy. van den Heuvel, W.J., Wieringh, R., van den Heuvel, L.P. Health policy (Amsterdam, Netherlands) (1997) [Pubmed]
  7. Survival effect of lung transplantation among patients with cystic fibrosis. Liou, T.G., Adler, F.R., Cahill, B.C., FitzSimmons, S.C., Huang, D., Hibbs, J.R., Marshall, B.C. JAMA (2001) [Pubmed]
  8. Fatal hyperammonemia following orthotopic lung transplantation. Lichtenstein, G.R., Kaiser, L.R., Tuchman, M., Palevsky, H.I., Kotloff, R.M., O'Brien, C.B., Furth, E.E., Raps, E.C., Berry, G.T. Gastroenterology (1997) [Pubmed]
  9. Inhaled iloprost to treat severe pulmonary hypertension. An uncontrolled trial. German PPH Study Group. Olschewski, H., Ghofrani, H.A., Schmehl, T., Winkler, J., Wilkens, H., Höper, M.M., Behr, J., Kleber, F.X., Seeger, W. Ann. Intern. Med. (2000) [Pubmed]
  10. Fatal hyperammonemia after orthotopic lung transplantation. Lichtenstein, G.R., Yang, Y.X., Nunes, F.A., Lewis, J.D., Tuchman, M., Tino, G., Kaiser, L.R., Palevsky, H.I., Kotloff, R.M., Furth, E.E., Bavaria, J.E., Stecker, M.M., Kaplan, P., Berry, G.T. Ann. Intern. Med. (2000) [Pubmed]
  11. A comparison of ganciclovir and acyclovir to prevent cytomegalovirus after lung transplantation. Duncan, S.R., Grgurich, W.F., Iacono, A.T., Burckart, G.J., Yousem, S.A., Paradis, I.L., Williams, P.A., Johnson, B.A., Griffith, B.P. Am. J. Respir. Crit. Care Med. (1994) [Pubmed]
  12. Successful renal transplantation after cyclosporine-associated hemolytic-uremic syndrome following bilateral lung transplantation. Butkus, D.E., Herrera, G.A., Raju, S.S. Transplantation (1992) [Pubmed]
  13. Preventive effect of inhaled nitric oxide and pentoxifylline on ischemia/reperfusion injury after lung transplantation. Thabut, G., Brugière, O., Lesèche, G., Stern, J.B., Fradj, K., Hervé, P., Jebrak, G., Marty, J., Fournier, M., Mal, H. Transplantation (2001) [Pubmed]
  14. Recurrence of Langerhans' cell granulomatosis following lung transplantation. Gabbay, E., Dark, J.H., Ashcroft, T., Milne, D., Gibson, G.J., Healy, M., Corris, P.A. Thorax (1998) [Pubmed]
  15. Carbon monoxide induces cytoprotection in rat orthotopic lung transplantation via anti-inflammatory and anti-apoptotic effects. Song, R., Kubo, M., Morse, D., Zhou, Z., Zhang, X., Dauber, J.H., Fabisiak, J., Alber, S.M., Watkins, S.C., Zuckerbraun, B.S., Otterbein, L.E., Ning, W., Oury, T.D., Lee, P.J., McCurry, K.R., Choi, A.M. Am. J. Pathol. (2003) [Pubmed]
  16. Eosinophilic granulocytes and interleukin-6 level in bronchoalveolar lavage fluid are associated with the development of obliterative bronchiolitis after lung transplantation. Scholma, J., Slebos, D.J., Boezen, H.M., van den Berg, J.W., van der Bij, W., de Boer, W.J., Koëter, G.H., Timens, W., Kauffman, H.F., Postma, D.S. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  17. Alterations in bronchoalveolar lavage and plasma endothelin-1 levels early after lung transplantation. Shennib, H., Serrick, C., Saleh, D., Adoumie, R., Stewart, D.J., Giaid, A. Transplantation (1995) [Pubmed]
  18. Ischemia reperfusion-induced dynamic changes of protein tyrosine phosphorylation during human lung transplantation. Keshavjee, S., Zhang, X.M., Fischer, S., Liu, M. Transplantation (2000) [Pubmed]
  19. Butylated hydroxytoluene and N-acetylcysteine attenuates tumor necrosis factor-alpha (TNF-alpha) secretion and TNF-alpha mRNA expression in alveolar macrophages from human lung transplant recipients in vitro. Hultén, L.M., Lindmark, H., Scherstén, H., Wiklund, O., Nilsson, F.N., Riise, G.C. Transplantation (1998) [Pubmed]
  20. Neutrophils, unopposed neutrophil elastase, and alpha1-antiprotease defenses following human lung transplantation. Meyer, K.C., Nunley, D.R., Dauber, J.H., Iacono, A.T., Keenan, R.J., Cornwell, R.D., Love, R.B. Am. J. Respir. Crit. Care Med. (2001) [Pubmed]
  21. Induction of red blood cell destruction by graft-derived antibodies after minor ABO-mismatched heart and lung transplantation. Hunt, B.J., Yacoub, M., Amin, S., Devenish, A., Contreras, M. Transplantation (1988) [Pubmed]
  22. Lung retrieval from non-heart beating cadavers with the use of a rat lung transplant model. Kiser, A.C., Ciriaco, P., Hoffmann, S.C., Egan, T.M. J. Thorac. Cardiovasc. Surg. (2001) [Pubmed]
  23. Cyclosporine does not affect in vitro bronchial smooth muscle contractions in treated Lewis rats. Tavakoli, R., Daly, R.C., McGregor, C.G., Frossard, N. J. Heart Lung Transplant. (1994) [Pubmed]
  24. Histamine release from pulmonary mast cells after lung transplantation in rats. Minami, M., Nakahara, K., Matsumura, A., Mizuta, T., Yoon, H.E., Sakaguchi, M., Mochizuki, T., Yamatodani, A., Matsuda, H. J. Heart Lung Transplant. (1995) [Pubmed]
  25. Effect of calcitriol on bone loss after cardiac or lung transplantation. Sambrook, P., Henderson, N.K., Keogh, A., MacDonald, P., Glanville, A., Spratt, P., Bergin, P., Ebeling, P., Eisman, J. J. Bone Miner. Res. (2000) [Pubmed]
  26. Supporting future surgical innovation. Lung transplantation as a case study. Reemtsma, K., Gelijns, A.C., Sisk, J.E., Arons, R.R., Boozang, P.M., Berland, G.K., Evans, C.M., Smith, C.R. Ann. Surg. (1993) [Pubmed]
  27. Azithromycin: a plea for multicenter randomized studies in lung transplantation. Williams, T.J., Verleden, G.M. Am. J. Respir. Crit. Care Med. (2005) [Pubmed]
  28. Renal hemodynamics after lung transplantation. A prospective study. Navis, G., Broekroelofs, J., Mannes, G.P., van der Bij, W., de Boer, W.J., Tegzees, A.M., de Jong, P.E. Transplantation (1996) [Pubmed]
  29. Ganciclovir. An update of its use in the prevention of cytomegalovirus infection and disease in transplant recipients. Noble, S., Faulds, D. Drugs (1998) [Pubmed]
  30. Role of CXCL9/CXCR3 chemokine biology during pathogenesis of acute lung allograft rejection. Belperio, J.A., Keane, M.P., Burdick, M.D., Lynch, J.P., Zisman, D.A., Xue, Y.Y., Li, K., Ardehali, A., Ross, D.J., Strieter, R.M. J. Immunol. (2003) [Pubmed]
  31. Interleukin-8 release during early reperfusion predicts graft function in human lung transplantation. De Perrot, M., Sekine, Y., Fischer, S., Waddell, T.K., McRae, K., Liu, M., Wigle, D.A., Keshavjee, S. Am. J. Respir. Crit. Care Med. (2002) [Pubmed]
  32. The role of innate immunity in acute allograft rejection after lung transplantation. Palmer, S.M., Burch, L.H., Davis, R.D., Herczyk, W.F., Howell, D.N., Reinsmoen, N.L., Schwartz, D.A. Am. J. Respir. Crit. Care Med. (2003) [Pubmed]
  33. Interleukin-6 and interferon-gamma gene polymorphisms in the development of bronchiolitis obliterans syndrome after lung transplantation. Lu, K.C., Jaramillo, A., Lecha, R.L., Schuessler, R.B., Aloush, A., Trulock, E.P., Mendeloff, E.N., Huddleston, C.B., Alexander Patterson, G., Mohanakumar, T. Transplantation (2002) [Pubmed]
  34. Increased expression of nitric oxide synthase in human lung transplants after nitric oxide inhalation. Cardella, J.A., Keshavjee, S.H., Bai, X.H., Yeoh, J.S., Granton, J.T., Meade, M.O., Matte-Martyn, A., Waddell, T.K., Liu, M. Transplantation (2004) [Pubmed]
  35. In vivo regulation of von willebrand factor synthesis: von Willebrand factor production in endothelial cells after lung transplantation between normal pigs and von Willebrand factor-deficient pigs. Brouland, J.P., Egan, T., Roussi, J., Bonneau, M., Pignaud, G., Bal, C., Vaiman, M., André, P., Hervé, P., Mazmanian, G.M., Drouet, L. Arterioscler. Thromb. Vasc. Biol. (1999) [Pubmed]
  36. Outcomes of intensive care unit care in adults with cystic fibrosis. Sood, N., Paradowski, L.J., Yankaskas, J.R. Am. J. Respir. Crit. Care Med. (2001) [Pubmed]
  37. Addition of inhaled fluticasone propionate to systemic immunosuppression after lung transplantation: Cushing's syndrome in patients on itraconazole comedication. Schmid, C., Naef, R., Speich, R., Boehler, A. Transplantation (2003) [Pubmed]
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