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Antitrichomonas in vitro activity of Cussonia holstii Engl.

Cussonia holstii is a traditional medicinal plant used in Kenya, which has not been studied chemically up-to-date. Upon biological screening, a substantial antitrichomonas activity was found in the dichloromethane extract of the bark of Cussonia holstii. A detailed chromatographic study using centrifugal partition chromatography revealed that a pentacyclic triterpenoid, i.e., hederagenin, is the antitrichomonas constituent of the plant with a IC50 of 2.8 microM.[1]

References

  1. Antitrichomonas in vitro activity of Cussonia holstii Engl. He, W., Van Puyvelde, L., Maes, L., Bosselaers, J., De Kimpe, N. Nat. Prod. Res. (2003) [Pubmed]
 
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