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Tench, C.M. et al.

Tench, McCarthy, McCurdie, White, D'Cruz,

Fatigue in systemic lupus erythematosus: a randomized controlled trial of exercise.

OBJECTIVE: To test the efficacy of a graded aerobic exercise programme in treating fatigue in systemic lupus erythematosus. METHODS: Ninety-three patients with systemic lupus erythematosus without active disease in any major organ were randomized, using a minimization protocol, to 12 weeks of graded exercise therapy, relaxation therapy or no intervention. RESULTS: Analysis by intention to treat showed that 16 of the 33 (49%) patients in the exercise group rated themselves as 'much' or 'very much' better compared with eight out of 29 (28%) in the relaxation group and five out of 32 (16%) in the control group (chi2=8.3, df=2, P=0.02). Fatigue improved significantly on one out of three measures after exercise therapy and there was a trend for fatigue to improve on all measures after exercise. CONCLUSION: These findings support the use of appropriately prescribed graded aerobic exercise in the management of patients with fatigue and systemic lupus erythematosus.[1]

References

Fatigue in systemic lupus erythematosus: a randomized controlled trial of exercise. Tench, C.M., McCarthy, J., McCurdie, I., White, P.D., D'Cruz, D.P. Rheumatology (Oxford, England) (2003) [Pubmed]

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