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MeSH Review


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Disease relevance of Exercise


Psychiatry related information on Exercise


High impact information on Exercise


Chemical compound and disease context of Exercise


Biological context of Exercise


Anatomical context of Exercise


Associations of Exercise with chemical compounds

  • In the 7 patients with the most severe DPF, mean arterial PO2 fell from 68 mm Hg at rest to 51 mm Hg at peak aerobic exercise, and mean TxB2 increased to twice the value at rest [30].
  • Effects of isometric exercise on serum creatine phosphokinase activity [31].
  • During isometric exercise, dobutamine tended to decrease mitral regurgitant volume (24 +/- 12 vs. 31 +/- 17 ml; NS) when compared with control exercise [32].
  • In summary, this study suggests that physical exercise conditioning reduces fasting and postprandial lipoprotein levels by increasing the catabolism of triglyceride-rich particles [33].
  • Neither dobutamine nor nitroglycerin changed significantly forward stroke and mitral regurgitant volumes at rest and during isometric exercise in the six patients with resting mitral regurgitant fraction below the median [32].

Gene context of Exercise

  • PON1 activity, lipid levels, and oxidized LDL concentration were determined in 17 healthy young volunteers before and after a 16-weeks aerobic exercise training period [34].
  • Progression of dystrophic features and activation of mitogen-activated protein kinases and calcineurin by physical exercise, in hearts of mdx mice [35].
  • Future studies should examine changes in the actual protein content of SOCS3 in muscle and establish whether aerobic exercise is also effective in treating leptin resistance in humans [36].
  • In addition, the AR CAG repeat and aromatase TTTA repeat do not modify the effect of regular aerobic exercise on BMD [37].
  • Acute physical exercise increases growth hormone (GH) secretion, and GH regulates the expression of insulin-like growth factor I (IGF-I) and IGF-binding protein (IGFBP) 3 [38].

Analytical, diagnostic and therapeutic context of Exercise


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  6. The relationship of high density lipoprotein subfractions to alcohol consumption, other lifestyle factors, and coronary heart disease. Diehl, A.K., Fuller, J.H., Mattock, M.B., Salter, A.M., el-Gohari, R., Keen, H. Atherosclerosis (1988) [Pubmed]
  7. Neurotrophin levels and behaviour in BALB/c mice: impact of intermittent exposure to individual housing and wheel running. Zhu, S.W., Pham, T.M., Aberg, E., Brené, S., Winblad, B., Mohammed, A.H., Baumans, V. Behav. Brain Res. (2006) [Pubmed]
  8. The influence of arterial baroreceptors in man on the variability of blood pressure and plasma catecholamines in man. Sleight, P. Chest (1983) [Pubmed]
  9. Secretin--a new stress hormone? Oektedalen, O., Opstad, P.K., Schaffalitzky de Muckadell, O.B. Regul. Pept. (1982) [Pubmed]
  10. Elevation of dental pain threshold induced in man by physical exercise is not reversed by cyproheptadine-mediated suppression of growth hormone release. Kemppainen, P., Pertovaara, A., Huopaniemi, T., Johansson, G. Neurosci. Lett. (1986) [Pubmed]
  11. Effects of diet and exercise in men and postmenopausal women with low levels of HDL cholesterol and high levels of LDL cholesterol. Stefanick, M.L., Mackey, S., Sheehan, M., Ellsworth, N., Haskell, W.L., Wood, P.D. N. Engl. J. Med. (1998) [Pubmed]
  12. Decreased hypothalamic gonadotropin-releasing hormone secretion in male marathon runners. MacConnie, S.E., Barkan, A., Lampman, R.M., Schork, M.A., Beitins, I.Z. N. Engl. J. Med. (1986) [Pubmed]
  13. Plasma catecholamines in stress and exercise. Dimsdale, J.E., Moss, J. JAMA (1980) [Pubmed]
  14. Role of adenosine in the sympathetic activation produced by isometric exercise in humans. Costa, F., Biaggioni, I. J. Clin. Invest. (1994) [Pubmed]
  15. Effects of propranolol on the hepatic hemodynamic response to physical exercise in patients with cirrhosis. Bandi, J.C., García-Pagán, J.C., Escorsell, A., François, E., Moitinho, E., Rodés, J., Bosch, J. Hepatology (1998) [Pubmed]
  16. Simultaneous dipyridamole/maximal subjective exercise with 99mTc-MIBI SPECT: improved diagnostic yield in coronary artery disease. Candell-Riera, J., Santana-Boado, C., Castell-Conesa, J., Aguadé-Bruix, S., Olona, M., Palet, J., Cortadellas, J., García-Burillo, A., Soler-Soler, J. J. Am. Coll. Cardiol. (1997) [Pubmed]
  17. Management of hypertension by reduction in sympathetic activity. Mathias, C.J. Hypertension (1991) [Pubmed]
  18. Effects of 1-year treatment with octreotide on cardiac performance in patients with acromegaly. Colao, A., Cuocolo, A., Marzullo, P., Nicolai, E., Ferone, D., Florimonte, L., Salvatore, M., Lombardi, G. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  19. Guanfacine in essential hypertension: effects during rest and isometric exercise. Hedner, T., Nyberg, G., Mellstrand, T. Clin. Pharmacol. Ther. (1984) [Pubmed]
  20. Adrenergic function in patients with panic anxiety. Nesse, R.M., Cameron, O.G., Curtis, G.C., McCann, D.S., Huber-Smith, M.J. Arch. Gen. Psychiatry (1984) [Pubmed]
  21. AMP-activated protein kinase: the energy charge hypothesis revisited. Hardie, D.G., Hawley, S.A. Bioessays (2001) [Pubmed]
  22. Long-term treatment with the dual antithromboxane agent picotamide decreases microalbuminuria in normotensive type 2 diabetic patients. Giustina, A., Perini, P., Desenzani, P., Bossoni, S., Ianniello, P., Milani, M., Davì, G., Romanelli, G. Diabetes (1998) [Pubmed]
  23. Regulation of energy expenditure in aging humans. Poehlman, E.T., Horton, E.S. Annu. Rev. Nutr. (1990) [Pubmed]
  24. Interaction of exercise and insulin in type II diabetes mellitus. Wallberg-Henriksson, H. Diabetes Care (1992) [Pubmed]
  25. Effect of hydralazine on perfusion and metabolism in the leg during upright bicycle exercise in patients with heart failure. Wilson, J.R., Martin, J.L., Ferraro, N., Weber, K.T. Circulation (1983) [Pubmed]
  26. von Willebrand factor propeptide in vascular disorders: A tool to distinguish between acute and chronic endothelial cell perturbation. van Mourik, J.A., Boertjes, R., Huisveld, I.A., Fijnvandraat, K., Pajkrt, D., van Genderen, P.J., Fijnheer, R. Blood (1999) [Pubmed]
  27. Aerobic exercise attenuates airway inflammatory responses in a mouse model of atopic asthma. Pastva, A., Estell, K., Schoeb, T.R., Atkinson, T.P., Schwiebert, L.M. J. Immunol. (2004) [Pubmed]
  28. A reduced-fat diet and aerobic exercise in Japanese Americans with impaired glucose tolerance decreases intra-abdominal fat and improves insulin sensitivity but not beta-cell function. Carr, D.B., Utzschneider, K.M., Boyko, E.J., Asberry, P.J., Hull, R.L., Kodama, K., Callahan, H.S., Matthys, C.C., Leonetti, D.L., Schwartz, R.S., Kahn, S.E., Fujimoto, W.Y. Diabetes (2005) [Pubmed]
  29. No effect of growth hormone administration on substrate oxidation during exercise in young, lean men. Hansen, M., Morthorst, R., Larsson, B., Dall, R., Flyvbjerg, A., Rasmussen, M.H., Orskov, H., Kjaer, M., Lange, K.H. J. Physiol. (Lond.) (2005) [Pubmed]
  30. Thromboxane and prostacyclin (epoprostenol) during exercise in diffuse pulmonary fibrosis. Risk, C., Rie, M., Peterson, M., Kong, D., Woods, B., Watkins, W.D. Lancet (1982) [Pubmed]
  31. Effects of isometric exercise on serum creatine phosphokinase activity. Goode, D.J., Meltzer, H.Y. Arch. Gen. Psychiatry (1976) [Pubmed]
  32. Dynamic mitral regurgitation. An important determinant of the hemodynamic response to load alterations and inotropic therapy in severe heart failure. Keren, G., Katz, S., Strom, J., Sonnenblick, E.H., LeJemtel, T.H. Circulation (1989) [Pubmed]
  33. Physical exercise conditioning in the absence of weight loss reduces fasting and postprandial triglyceride-rich lipoprotein levels. Weintraub, M.S., Rosen, Y., Otto, R., Eisenberg, S., Breslow, J.L. Circulation (1989) [Pubmed]
  34. Paraoxonase1-192 polymorphism modulates the effects of regular and acute exercise on paraoxonase1 activity. Tomás, M., Elosua, R., Sentí, M., Molina, L., Vila, J., Anglada, R., Fitó, M., Covas, M.I., Marrugat, J. J. Lipid Res. (2002) [Pubmed]
  35. Progression of dystrophic features and activation of mitogen-activated protein kinases and calcineurin by physical exercise, in hearts of mdx mice. Nakamura, A., Yoshida, K., Takeda, S., Dohi, N., Ikeda, S. FEBS Lett. (2002) [Pubmed]
  36. Endurance training partially reverses dietary-induced leptin resistance in rodent skeletal muscle. Steinberg, G.R., Smith, A.C., Wormald, S., Malenfant, P., Collier, C., Dyck, D.J. Am. J. Physiol. Endocrinol. Metab. (2004) [Pubmed]
  37. Aerobic exercise and bone mineral density in middle-aged finnish men: a controlled randomized trial with reference to androgen receptor, aromatase, and estrogen receptor alpha gene polymorphisms small star, filled. Remes, T., Väisänen, S.B., Mahonen, A., Huuskonen, J., Kröger, H., Jurvelin, J.S., Penttilä, I.M., Rauramaa, R. Bone (2003) [Pubmed]
  38. Effect of marathon run on serum IGF-I and IGF-binding protein 1 and 3 levels. Koistinen, H., Koistinen, R., Selenius, L., Ylikorkala, Q., Seppälä, M. J. Appl. Physiol. (1996) [Pubmed]
  39. Interindividual differences in the susceptibility of the cortisol system: an important factor for the degree of hypercortisolism in stress situations? Berger, M., Bossert, S., Krieg, J.C., Dirlich, G., Ettmeier, W., Schreiber, W., von Zerssen, D. Biol. Psychiatry (1987) [Pubmed]
  40. Hypopituitary females have a high incidence of cardiovascular morbidity and an increased prevalence of cardiovascular risk factors. Bülow, B., Hagmar, L., Eskilsson, J., Erfurth, E.M. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  41. Nature of pulmonary hypertension in congestive heart failure. Effects of cardiac transplantation. Naeije, R., Lipski, A., Abramowicz, M., Lejeune, P., Mélot, C., Antoine, M., De Smet, J.M., Leclerc, J.L., Primo, G. Am. J. Respir. Crit. Care Med. (1994) [Pubmed]
  42. Assessment of the pathogenetic role of physical exercise in renal stone formation. Sakhaee, K., Nigam, S., Snell, P., Hsu, M.C., Pak, C.Y. J. Clin. Endocrinol. Metab. (1987) [Pubmed]
  43. Impaired cardiac reserve and exercise capacity in patients receiving long-term thyrotropin suppressive therapy with levothyroxine. Biondi, B., Fazio, S., Cuocolo, A., Sabatini, D., Nicolai, E., Lombardi, G., Salvatore, M., Saccà, L. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
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