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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Markers of cellular proliferation are expressed in cortical tubers.

p34cdc2, collapsin response mediator protein 4 (CRMP4), doublecortin ( DCX), HuD, and NeuN expression was assessed in tuber (n = 16) and subependymal giant cell astrocytoma (SEGA; n = 6) specimens in tuberous sclerosis complex to define the developmental phenotype and lineage of giant cells (CGs) in these lesions. Many GCs exhibited HuD and NeuN immunolabeling suggesting a differentiated neural phenotype. Giant cells in tubers, SEGAs and subependymal nodules in the Eker rat model of TSC expressed CRMP4 and DCX. Tubers and SEGAs exhibit a heterogeneous profile of differentiation and may share a common cellular lineage. Tubers may contain a subpopulation of newly generated cells.[1]

References

  1. Markers of cellular proliferation are expressed in cortical tubers. Lee, A., Maldonado, M., Baybis, M., Walsh, C.A., Scheithauer, B., Yeung, R., Parent, J., Weiner, H.L., Crino, P.B. Ann. Neurol. (2003) [Pubmed]
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