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Gene Review

DPYSL3  -  dihydropyrimidinase-like 3

Homo sapiens

Synonyms: CRMP-4, CRMP4, Collapsin response mediator protein 4, DRP-3, DRP3, ...
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Disease relevance of DPYSL3


High impact information on DPYSL3

  • Giant cells in tubers, SEGAs and subependymal nodules in the Eker rat model of TSC expressed CRMP4 and DCX [5].
  • However, the growth cone collapse-inducing protein Sema3A increases Cdk5 activity and promotes phosphorylation of CRMP2 (but not CRMP4) [6].
  • Moreover, chondroitin sulfate and CRMP-4 were found to be localized immuno-histochemically in overlapping distributions in the marginal zone and the subplate of the cerebral cortex [7].
  • CRMPs are released to culture supernatants of NTera-2 precursor cells and of neocortical neurons after cell death, and CRMP-4 is strongly expressed in the upper cortical plate of neonatal rat where cell death is abundant [7].
  • Differential expression of collapsin response mediator proteins (CRMP/ULIP) in subsets of oligodendrocytes in the postnatal rodent brain [8].

Biological context of DPYSL3


Anatomical context of DPYSL3

  • We have found pronounced CRMP-4 immunolabeling in certain neurons of the medial cortex, the homologous region to the dentate gyrus, but also in the dorsal and lateral cortices [10].
  • Our results show for the first time the expression of CRMP-4 in a reptile brain, where it appears to be expressed in regions where adult neurogenesis and/or neurite outgrowth occur [10].

Associations of DPYSL3 with chemical compounds


Other interactions of DPYSL3

  • Autoantibodies produced against member(s) of this family by patients with paraneoplastic neurological diseases have made it possible to clone a fifth human Ulip/CRMP and characterize its cellular and anatomical distribution in developing brain [12].

Analytical, diagnostic and therapeutic context of DPYSL3


  1. Structure and promoter analysis of the human unc-33-like phosphoprotein gene. E-box required for maximal expression in neuroblastoma and myoblasts. Matsuo, T., Stauffer, J.K., Walker, R.L., Meltzer, P., Thiele, C.J. J. Biol. Chem. (2000) [Pubmed]
  2. HUlip, a human homologue of unc-33-like phosphoprotein of Caenorhabditis elegans; Immunohistochemical localization in the developing human brain and patterns of expression in nervous system tumors. Choi, Y.L., Kim, C.J., Matsuo, T., Gaetano, C., Falconi, R., Suh, Y.L., Kim, S.H., Shin, Y.K., Park, S.H., Chi, J.G., Thiele, C.J. J. Neurooncol. (2005) [Pubmed]
  3. Comparison of microarray-based mRNA profiling technologies for identification of psychiatric disease and drug signatures. Jurata, L.W., Bukhman, Y.V., Charles, V., Capriglione, F., Bullard, J., Lemire, A.L., Mohammed, A., Pham, Q., Laeng, P., Brockman, J.A., Altar, C.A. J. Neurosci. Methods (2004) [Pubmed]
  4. Orofacial muscle activity of children who stutter: a preliminary study. Kelly, E.M., Smith, A., Goffman, L. Journal of speech and hearing research. (1995) [Pubmed]
  5. Markers of cellular proliferation are expressed in cortical tubers. Lee, A., Maldonado, M., Baybis, M., Walsh, C.A., Scheithauer, B., Yeung, R., Parent, J., Weiner, H.L., Crino, P.B. Ann. Neurol. (2003) [Pubmed]
  6. Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo. Cole, A.R., Causeret, F., Yadirgi, G., Hastie, C.J., McLauchlan, H., McManus, E.J., Hernández, F., Eickholt, B.J., Nikolic, M., Sutherland, C. J. Biol. Chem. (2006) [Pubmed]
  7. Collapsin response mediator proteins of neonatal rat brain interact with chondroitin sulfate. Franken, S., Junghans, U., Rosslenbroich, V., Baader, S.L., Hoffmann, R., Gieselmann, V., Viebahn, C., Kappler, J. J. Biol. Chem. (2003) [Pubmed]
  8. Differential expression of collapsin response mediator proteins (CRMP/ULIP) in subsets of oligodendrocytes in the postnatal rodent brain. Ricard, D., Stankoff, B., Bagnard, D., Aguera, M., Rogemond, V., Antoine, J.C., Spassky, N., Zalc, B., Lubetzki, C., Belin, M.F., Honnorat, J. Mol. Cell. Neurosci. (2000) [Pubmed]
  9. Experimental and bioinformatics comparison of gene expression between T cells from TIL of liver cancer and T cells from UniGene. Li, B., Perabekam, S., Liu, G., Yin, M., Song, S., Larson, A. J. Gastroenterol. (2002) [Pubmed]
  10. CRMP-4 expression in the adult cerebral cortex and other telencephalic areas of the lizard Podarcis hispanica. Nacher, J., Soriano, S., Varea, E., Molowny, A., Ponsoda, X., Lopez-Garcia, C. Brain Res. Dev. Brain Res. (2002) [Pubmed]
  11. Human replication protein A preferentially binds cisplatin-damaged duplex DNA in vitro. Patrick, S.M., Turchi, J.J. Biochemistry (1998) [Pubmed]
  12. Isolation and expression pattern of human Unc-33-like phosphoprotein 6/collapsin response mediator protein 5 (Ulip6/CRMP5): coexistence with Ulip2/CRMP2 in Sema3a- sensitive oligodendrocytes. Ricard, D., Rogemond, V., Charrier, E., Aguera, M., Bagnard, D., Belin, M.F., Thomasset, N., Honnorat, J. J. Neurosci. (2001) [Pubmed]
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