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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Growth phase-dependent changes in the subcellular localization of pre-B-cell colony-enhancing factor.

A cDNA encoding the homolog of the human pre-B-cell colony-enhancing factor (PBEF), a cytokine-like secreted protein, was isolated from a rat cDNA library. This protein existed in both the cytoplasm and nucleus of the cells, and the amount was higher in the cytoplasm than in the nucleus of proliferating PC-12 and Swiss 3T3 cells but higher in the nucleus than in the cytoplasm of the PC-12 cells treated with nerve growth factor and the 3T3 cells grown to a confluent state. Thus, the so-called PBEF is not a cytokine-like secreted protein but an intracellular protein associated with the cell cycle.[1]

References

  1. Growth phase-dependent changes in the subcellular localization of pre-B-cell colony-enhancing factor. Kitani, T., Okuno, S., Fujisawa, H. FEBS Lett. (2003) [Pubmed]
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