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MeSH Review

Swiss 3T3 Cells

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Disease relevance of Swiss 3T3 Cells


High impact information on Swiss 3T3 Cells


Chemical compound and disease context of Swiss 3T3 Cells


Biological context of Swiss 3T3 Cells


Anatomical context of Swiss 3T3 Cells


Associations of Swiss 3T3 Cells with chemical compounds


Gene context of Swiss 3T3 Cells

  • The epidermal growth factor-like domain of recombinant human thrombomodulin exhibits mitogenic activity for Swiss 3T3 cells [26].
  • In contrast to that of Mnk1, the activity of overexpressed Mnk2 is high under control conditions and could only be reduced substantially by a combination of PD98059 and SB203580, while the activity of endogenous Mnk2 in Swiss 3T3 cells was hardly affected upon treatment with these inhibitors [27].
  • These results indicate that both ras p21 and smg p21 are mitogenic in Swiss 3T3 cells but that their actions are slightly different [28].
  • Thus, the overall results indicated that the rTME1-6 peptide had mitogenic activity for Swiss 3T3 cells, accelerated DNA synthesis and glucose uptake, and that the mitogenic activity might be mediated by binding of the peptide to a specific site different from the EGF receptor [26].
  • HD1 overexpression in stably transfected Swiss 3T3 cells caused a severe delay during the G2/M phases of the cell cycle [29].

Analytical, diagnostic and therapeutic context of Swiss 3T3 Cells


  1. Mediation of virion penetration into vascular cells by association of basic fibroblast growth factor with herpes simplex virus type 1. Baird, A., Florkiewicz, R.Z., Maher, P.A., Kaner, R.J., Hajjar, D.P. Nature (1990) [Pubmed]
  2. Mastoparan, a novel mitogen for Swiss 3T3 cells, stimulates pertussis toxin-sensitive arachidonic acid release without inositol phosphate accumulation. Gil, J., Higgins, T., Rozengurt, E. J. Cell Biol. (1991) [Pubmed]
  3. Cellular responses to Pyrularia thionin are mediated by Ca2+ influx and phospholipase A2 activation and are inhibited by thionin tyrosine iodination. Evans, J., Wang, Y.D., Shaw, K.P., Vernon, L.P. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  4. Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility. Takaishi, K., Kikuchi, A., Kuroda, S., Kotani, K., Sasaki, T., Takai, Y. Mol. Cell. Biol. (1993) [Pubmed]
  5. Pasteurella multocida toxin, a potent mitogen, increases inositol 1,4,5-trisphosphate and mobilizes Ca2+ in Swiss 3T3 cells. Staddon, J.M., Barker, C.J., Murphy, A.C., Chanter, N., Lax, A.J., Michell, R.H., Rozengurt, E. J. Biol. Chem. (1991) [Pubmed]
  6. Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway. Rouault, J.P., Falette, N., Guéhenneux, F., Guillot, C., Rimokh, R., Wang, Q., Berthet, C., Moyret-Lalle, C., Savatier, P., Pain, B., Shaw, P., Berger, R., Samarut, J., Magaud, J.P., Ozturk, M., Samarut, C., Puisieux, A. Nat. Genet. (1996) [Pubmed]
  7. Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Chung, J., Kuo, C.J., Crabtree, G.R., Blenis, J. Cell (1992) [Pubmed]
  8. Effects of bombesin and insulin on inositol (1,4,5)trisphosphate and inositol (1,3,4)trisphosphate formation in Swiss 3T3 cells. Heslop, J.P., Blakeley, D.M., Brown, K.D., Irvine, R.F., Berridge, M.J. Cell (1986) [Pubmed]
  9. Platelet-derived growth factor elicits cyclic AMP accumulation in Swiss 3T3 cells: role of prostaglandin production. Rozengurt, E., Stroobant, P., Waterfield, M.D., Deuel, T.F., Keehan, M. Cell (1983) [Pubmed]
  10. Sphingosine 1-phosphate rapidly activates the mitogen-activated protein kinase pathway by a G protein-dependent mechanism. Wu, J., Spiegel, S., Sturgill, T.W. J. Biol. Chem. (1995) [Pubmed]
  11. Heparan sulfates of mouse cells. Analysis of parent and transformed 3T3 cell lines. Underhill, C.B., Keller, J.M. J. Cell. Physiol. (1977) [Pubmed]
  12. Sensitivity to bleomycin of JTC-11 cells modified by serum concentration and underlaid 3T3 cells. Kimura, H., Yamada, T., Aoyama, T., Norimura, T., Tsuchiya, T. J. UOEH (1984) [Pubmed]
  13. Identification and characterization of receptors specific for human pancreatic secretory trypsin inhibitor. Niinobu, T., Ogawa, M., Murata, A., Nishijima, J., Mori, T. J. Exp. Med. (1990) [Pubmed]
  14. Activation of endogenous thrombin receptors causes clustering and sensitization of epidermal growth factor receptors of swiss 3T3 cells without transactivation. Crouch, M.F., Davy, D.A., Willard, F.S., Berven, L.A. J. Cell Biol. (2001) [Pubmed]
  15. Initiation of nuclear DNA replication: evidence for formation of committed prereplicative cellular state. Das, M. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  16. Steroid hormones mediate reversible phenotypic transition between transformed and untransformed states in mouse fibroblasts. Armelin, M.C., Armelin, H.A. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  17. Interactions between the receptors for platelet-derived growth factor and epidermal growth factor. Bowen-Pope, D.F., Dicorleto, P.E., Ross, R. J. Cell Biol. (1983) [Pubmed]
  18. Rho- and rac-dependent assembly of focal adhesion complexes and actin filaments in permeabilized fibroblasts: an essential role for ezrin/radixin/moesin proteins. Mackay, D.J., Esch, F., Furthmayr, H., Hall, A. J. Cell Biol. (1997) [Pubmed]
  19. The hyaluronate receptor is associated with actin filaments. Lacy, B.E., Underhill, C.B. J. Cell Biol. (1987) [Pubmed]
  20. Cdc42Hs facilitates cytoskeletal reorganization and neurite outgrowth by localizing the 58-kD insulin receptor substrate to filamentous actin. Govind, S., Kozma, R., Monfries, C., Lim, L., Ahmed, S. J. Cell Biol. (2001) [Pubmed]
  21. Platelet-derived growth factor stimulates formation of active p21ras.GTP complex in Swiss mouse 3T3 cells. Satoh, T., Endo, M., Nakafuku, M., Nakamura, S., Kaziro, Y. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  22. Identification of a putative target for Rho as the serine-threonine kinase protein kinase N. Amano, M., Mukai, H., Ono, Y., Chihara, K., Matsui, T., Hamajima, Y., Okawa, K., Iwamatsu, A., Kaibuchi, K. Science (1996) [Pubmed]
  23. Thrombin receptor activation elicits rapid protein tyrosine phosphorylation and stimulation of the raf-1/MAP kinase pathway preceding delayed mitogenesis in cultured rat aortic smooth muscle cells: evidence for an obligate autocrine mechanism promoting cell proliferation induced by G-protein-coupled receptor agonist. Molloy, C.J., Pawlowski, J.E., Taylor, D.S., Turner, C.E., Weber, H., Peluso, M. J. Clin. Invest. (1996) [Pubmed]
  24. Temporal relationship between inositol polyphosphate formation and increases in cytosolic Ca2+ in quiescent 3T3 cells stimulated by platelet-derived growth factor, bombesin and vasopressin. Nånberg, E., Rozengurt, E. EMBO J. (1988) [Pubmed]
  25. Protein kinase C mediates platelet-derived growth factor-induced tyrosine phosphorylation of p42. Kazlauskas, A., Cooper, J.A. J. Cell Biol. (1988) [Pubmed]
  26. The epidermal growth factor-like domain of recombinant human thrombomodulin exhibits mitogenic activity for Swiss 3T3 cells. Hamada, H., Ishii, H., Sakyo, K., Horie, S., Nishiki, K., Kazama, M. Blood (1995) [Pubmed]
  27. The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells. Scheper, G.C., Morrice, N.A., Kleijn, M., Proud, C.G. Mol. Cell. Biol. (2001) [Pubmed]
  28. Microinjection of smg/rap1/Krev-1 p21 into Swiss 3T3 cells induces DNA synthesis and morphological changes. Yoshida, Y., Kawata, M., Miura, Y., Musha, T., Sasaki, T., Kikuchi, A., Takai, Y. Mol. Cell. Biol. (1992) [Pubmed]
  29. Identification of mouse histone deacetylase 1 as a growth factor-inducible gene. Bartl, S., Taplick, J., Lagger, G., Khier, H., Kuchler, K., Seiser, C. Mol. Cell. Biol. (1997) [Pubmed]
  30. Microinjected c-myc as a competence factor. Kaczmarek, L., Hyland, J.K., Watt, R., Rosenberg, M., Baserga, R. Science (1985) [Pubmed]
  31. Molecular cloning of the bombesin/gastrin-releasing peptide receptor from Swiss 3T3 cells. Battey, J.F., Way, J.M., Corjay, M.H., Shapira, H., Kusano, K., Harkins, R., Wu, J.M., Slattery, T., Mann, E., Feldman, R.I. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  32. Existence of different Fos/Jun complexes during the G0-to-G1 transition and during exponential growth in mouse fibroblasts: differential role of Fos proteins. Kovary, K., Bravo, R. Mol. Cell. Biol. (1992) [Pubmed]
  33. Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate. Zachary, I., Sinnett-Smith, J., Rozengurt, E. J. Biol. Chem. (1992) [Pubmed]
  34. Stimulation of tyrosine kinase activity in anti-phosphotyrosine immune complexes of Swiss 3T3 cell lysates occurs rapidly after addition of bombesin, vasopressin, and endothelin to intact cells. Zachary, I., Sinnett-Smith, J., Rozengurt, E. J. Biol. Chem. (1991) [Pubmed]
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