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Gene Review

Nampt  -  nicotinamide phosphoribosyltransferase

Rattus norvegicus

Synonyms: NAmPRTase, Nicotinamide phosphoribosyltransferase, PBEF, Pbef, Pbef1, ...
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Disease relevance of Pbef1


High impact information on Pbef1


Biological context of Pbef1


Anatomical context of Pbef1

  • Recently, Fukuhara et al. have shown that the novel visfatin is predominantly released from visceral adipocytes and shares metabolic functions with insulin [3].
  • Recently, visfatin, a new adipocytokine, known as a pre-B cell colony-enhancing factor, has been isolated from visceral fat deposits [4].
  • Thus, apelin and visfatin are unique among adipose tissue hormones in that they are upregulated in the obese state and both exert primarily beneficial effects [1].
  • Visfatin binds to the insulin receptor at a site distinct from insulin and exerts hypoglycemic effect by reducing glucose release from hepatocytes and stimulating glucose utilization in peripheral tissues [1].

Associations of Pbef1 with chemical compounds


Analytical, diagnostic and therapeutic context of Pbef1

  • Moreover, visfatin sequence analysis was performed in WOKW, DA rats, and disease-resistant Fisher 344, Lewis, Brown Norway, and Karlsburg wild rats [3].
  • These findings prompted us to clarify the visfatin gene expression from visceral and subcutaneous adipocytes in WOKW rats, as an animal model for polygenically inherited metabolic syndrome, compared to lean Dark Agouti (DA) rats [3].


  1. Apelin and visfatin: unique "beneficial" adipokines upregulated in obesity? Bełtowski, J. Med. Sci. Monit. (2006) [Pubmed]
  2. Growth phase-dependent changes in the subcellular localization of pre-B-cell colony-enhancing factor. Kitani, T., Okuno, S., Fujisawa, H. FEBS Lett. (2003) [Pubmed]
  3. Visfatin: gene expression in isolated adipocytes and sequence analysis in obese WOKW rats compared with lean control rats. Klöting, N., Klöting, I. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  4. Effect of PPAR-alpha and -gamma agonist on the expression of visfatin, adiponectin, and TNF-alpha in visceral fat of OLETF rats. Choi, K.C., Ryu, O.H., Lee, K.W., Kim, H.Y., Seo, J.A., Kim, S.G., Kim, N.H., Choi, D.S., Baik, S.H., Choi, K.M. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
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