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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Alteration of the striatal dopaminergic system in human narcolepsy.

Striatal D2/D3 dopaminergic receptors have been proposed to play a role in cataplexy. The authors studied the striatal presynaptic dopamine transporter and postsynaptic D2-receptors in seven patients with narcolepsy and seven control subjects using [123I](N)-(3-iodopropene-2-yl)-2beta-carbomethoxy-3beta-(4-chlorophenyl)tropane and [123I](S)-2-hydroxy-3-iodo-6-methoxy-([1-ethyl-2-pyrrolidinyl]methyl)benzamide SPECT. D2-receptor binding was elevated in narcolepsy (p = 0.017) and correlated with the frequency of cataplectic and sleep attacks (R > or = 0.844, p < or = 0.017). The human striatal dopaminergic system is altered in vivo in narcolepsy/cataplexy.[1]


  1. Alteration of the striatal dopaminergic system in human narcolepsy. Eisensehr, I., Linke, R., Tatsch, K., von Lindeiner, H., Kharraz, B., Gildehaus, F.J., Eberle, R., Pollmacher, T., Schuld, A., Noachtar, S. Neurology (2003) [Pubmed]
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