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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Platelet-derived growth factor and bone morphogenetic protein in the healing of mandibular fractures in rats.

We studied the effects of platelet-derived growth factor-B (PDGF-B) and bone morphogenetic protein-2 (BMP-2) during the healing of mandibular closed fractures in rats by immunohistochemical methods. Unilateral closed fractures were created in the mandibles of thirty 12-week-old rats. BMP-2 was expressed during all stages of healing, but PDGF-B was expressed mainly in the early and middle stages, and not in the later stage of the healing process. We conclude that PDGF-B was associated with the proliferation and migration of primitive mesenchymal cells. BMP-2 was related to the differentiation of mesenchymal cells into osteoblasts and chondroblasts. PDGF-B and BMP-2 both have distinct regulatory effects on the healing of fractures.[1]

References

  1. Platelet-derived growth factor and bone morphogenetic protein in the healing of mandibular fractures in rats. Rasubala, L., Yoshikawa, H., Nagata, K., Iijima, T., Ohishi, M. The British journal of oral & maxillofacial surgery. (2003) [Pubmed]
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