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Gene Review

Bmp1  -  bone morphogenetic protein 1

Rattus norvegicus

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Disease relevance of Bmp1


High impact information on Bmp1


Biological context of Bmp1


Anatomical context of Bmp1


Associations of Bmp1 with chemical compounds

  • The analgoue [Bmp1, Val8] -HCT, with a deaminated cysteine residue at the N-terminus, was about 6 times more potent than HCT and slightly longer-acting than [Val8] -HCT [19].
  • The BMP can be separated from bone matrix by extraction with 4 M guanidine hydrochloride (GuHCl) or degraded in situ by endogenous proteolytic enzymes to deactivate the matrix [20].
  • Activin/BMP receptors (ActRIA, ActRIB, ActRIIA, and ActRIIB), beta glycan, and Smad 1-8 mRNAs were expressed by the ovary [21].
  • Bone morphogenetic proteins belong to the transforming growth factor-beta superfamily and act through serine/threonine kinase type I and type II receptors such as bone morphogenetic protein receptor type I and type II [22].
  • Daidzein enhances osteoblast growth that may be mediated by increased bone morphogenetic protein (BMP) production [23].

Regulatory relationships of Bmp1


Other interactions of Bmp1


Analytical, diagnostic and therapeutic context of Bmp1

  • INTRODUCTION: Although researchers frequently opt to use osteogenic cells for osteogenic bone morphogenetic protein (BMP)-based ex vivo gene therapy to improve bone healing, it remains unclear whether the osteogenic potential of a cellular vehicle affects the outcome of bone healing applications [30].
  • The expression of activin/BMP receptor, Smad, and beta glycan mRNAs by postnatal rat ovaries were investigated by real-time PCR [21].
  • The molecular weight of BMP was estimated to be about 20.0 kDa by SDS-PAGE, and the pI value was 8.8 by IEF [31].
  • To clarify the possible involvement of BMP and BMPR-II in the development of hypoxic PH, the expression of BMP-2, BMPR-II, and their downstream signals were investigated in rat lung under normal and hypoxic conditions by RT-PCR, immunoblot, and immunohistochemical methods [5].
  • Whereas bone morphogenetic protein receptor type I expression was low in rat brain, in situ hybridization studies performed with specific digoxigenin-labelled riboprobes revealed the presence of bone morphogenetic protein receptor type II-positive cells throughout the brain, with a notable localization in dopaminergic cells of the substantia nigra [22].


  1. Faulty bone morphogenetic protein signaling in esophageal atresia with tracheoesophageal fistula. Crowley, A.R., Mehta, S.S., Hembree, M.J., Preuett, B.L., Prasadan, K.L., Sharp, S.W., Yew, H., McFall, C.R., Benjes, C.L., Tulachan, S.S., Gittes, G.K., Snyder, C.L. J. Pediatr. Surg. (2006) [Pubmed]
  2. Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension. McMurtry, M.S., Archer, S.L., Altieri, D.C., Bonnet, S., Haromy, A., Harry, G., Bonnet, S., Puttagunta, L., Michelakis, E.D. J. Clin. Invest. (2005) [Pubmed]
  3. Biophysical comparison of BMP-2, ProBMP-2, and the free pro-peptide reveals stabilization of the pro-peptide by the mature growth factor. Hillger, F., Herr, G., Rudolph, R., Schwarz, E. J. Biol. Chem. (2005) [Pubmed]
  4. Regulatory roles of bone morphogenetic proteins and glucocorticoids in catecholamine production by rat pheochromocytoma cells. Kano, Y., Otsuka, F., Takeda, M., Suzuki, J., Inagaki, K., Miyoshi, T., Miyamoto, M., Otani, H., Ogura, T., Makino, H. Endocrinology (2005) [Pubmed]
  5. Downregulation of type II bone morphogenetic protein receptor in hypoxic pulmonary hypertension. Takahashi, H., Goto, N., Kojima, Y., Tsuda, Y., Morio, Y., Muramatsu, M., Fukuchi, Y. Am. J. Physiol. Lung Cell Mol. Physiol. (2006) [Pubmed]
  6. Bone cell differentiation and growth factors. Urist, M.R., DeLange, R.J., Finerman, G.A. Science (1983) [Pubmed]
  7. Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts. Gazzerro, E., Gangji, V., Canalis, E. J. Clin. Invest. (1998) [Pubmed]
  8. Platelet-derived growth factor inhibits bone regeneration induced by osteogenin, a bone morphogenetic protein, in rat craniotomy defects. Marden, L.J., Fan, R.S., Pierce, G.F., Reddi, A.H., Hollinger, J.O. J. Clin. Invest. (1993) [Pubmed]
  9. IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes. Hsieh, J., Aimone, J.B., Kaspar, B.K., Kuwabara, T., Nakashima, K., Gage, F.H. J. Cell Biol. (2004) [Pubmed]
  10. Bone morphogenetic protein 9 induces the transcriptome of basal forebrain cholinergic neurons. Lopez-Coviella, I., Follettie, M.T., Mellott, T.J., Kovacheva, V.P., Slack, B.E., Diesl, V., Berse, B., Thies, R.S., Blusztajn, J.K. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  11. Extracellular signal-related kinase and bone morphogenetic protein expression during distraction osteogenesis of the mandible: in vivo evidence of a mechanotransduction mechanism for differentiation and osteogenesis by mesenchymal precursor cells. Rhee, S.T., El-Bassiony, L., Buchman, S.R. Plast. Reconstr. Surg. (2006) [Pubmed]
  12. Endogenous patterns of TGFbeta superfamily signaling during early Xenopus development. Faure, S., Lee, M.A., Keller, T., ten Dijke, P., Whitman, M. Development (2000) [Pubmed]
  13. FGF18 represses noggin expression and is induced by calcineurin. Reinhold, M.I., Abe, M., Kapadia, R.M., Liao, Z., Naski, M.C. J. Biol. Chem. (2004) [Pubmed]
  14. The bone morphogenetic protein type Ib receptor is a major mediator of glial differentiation and cell survival in adult hippocampal progenitor cell culture. Brederlau, A., Faigle, R., Elmi, M., Zarebski, A., Sjöberg, S., Fujii, M., Miyazono, K., Funa, K. Mol. Biol. Cell (2004) [Pubmed]
  15. Inhibins differentially antagonize activin and bone morphogenetic protein action in a mouse adrenocortical cell line. Farnworth, P.G., Stanton, P.G., Wang, Y., Escalona, R., Findlay, J.K., Ooi, G.T. Endocrinology (2006) [Pubmed]
  16. Bone marrow stromal cells upregulate expression of bone morphogenetic proteins 2 and 4, gap junction protein connexin-43 and synaptophysin after stroke in rats. Zhang, C., Li, Y., Chen, J., Gao, Q., Zacharek, A., Kapke, A., Chopp, M. Neuroscience (2006) [Pubmed]
  17. Dentin resorption and cementum-like tissue formation by bone morphogenetic protein application. Miyaji, H., Sugaya, T., Kato, K., Kawamura, N., Tsuji, H., Kawanami, M. J. Periodont. Res. (2006) [Pubmed]
  18. GDF11 forms a bone morphogenetic protein 1-activated latent complex that can modulate nerve growth factor-induced differentiation of PC12 cells. Ge, G., Hopkins, D.R., Ho, W.B., Greenspan, D.S. Mol. Cell. Biol. (2005) [Pubmed]
  19. Analogues of human calcitonin. II. Influence of modifications in amino acid positions 1, 8 and 22 on hypocalcemic activity in the rat. Maier, R., Kamber, B., Riniker, B., Rittel, W. Horm. Metab. Res. (1975) [Pubmed]
  20. Growth factors, mitogens, cytokines, and bone morphogenetic protein in induced chondrogenesis in tissue culture. Kawamura, M., Urist, M.R. Dev. Biol. (1988) [Pubmed]
  21. Expression and localization of activin receptors, Smads, and beta glycan to the postnatal rat ovary. Drummond, A.E., Le, M.T., Ethier, J.F., Dyson, M., Findlay, J.K. Endocrinology (2002) [Pubmed]
  22. Distribution of bone morphogenetic protein and bone morphogenetic protein receptor transcripts in the rodent nervous system and up-regulation of bone morphogenetic protein receptor type II in hippocampal dentate gyrus in a rat model of global cerebral ischemia. Charytoniuk, D.A., Traiffort, E., Pinard, E., Issertial, O., Seylaz, J., Ruat, M. Neuroscience (2000) [Pubmed]
  23. Daidzein enhances osteoblast growth that may be mediated by increased bone morphogenetic protein (BMP) production. Jia, T.L., Wang, H.Z., Xie, L.P., Wang, X.Y., Zhang, R.Q. Biochem. Pharmacol. (2003) [Pubmed]
  24. Cross-talk between the Smad1 and Ras/MEK signaling pathways for TGFbeta. Yue, J., Frey, R.S., Mulder, K.M. Oncogene (1999) [Pubmed]
  25. Growth hormone induces bone morphogenetic proteins and bone-related proteins in the developing rat periodontium. Li, H., Bartold, P.M., Young, W.G., Xiao, Y., Waters, M.J. J. Bone Miner. Res. (2001) [Pubmed]
  26. Signaling by bone morphogenetic proteins and Smad1 modulates the postnatal differentiation of cerebellar cells. Angley, C., Kumar, M., Dinsio, K.J., Hall, A.K., Siegel, R.E. J. Neurosci. (2003) [Pubmed]
  27. Krüppel-like factor 4 (KLF4/GKLF) is a target of bone morphogenetic proteins and transforming growth factor beta 1 in the regulation of vascular smooth muscle cell phenotype. King, K.E., Iyemere, V.P., Weissberg, P.L., Shanahan, C.M. J. Biol. Chem. (2003) [Pubmed]
  28. Multiple routes to astrocytic differentiation in the CNS. Rajan, P., McKay, R.D. J. Neurosci. (1998) [Pubmed]
  29. Crystal structures of the heparan sulfate-binding domain of follistatin. Insights into ligand binding. Innis, C.A., Hyvönen, M. J. Biol. Chem. (2003) [Pubmed]
  30. Converse relationship between in vitro osteogenic differentiation and in vivo bone healing elicited by different populations of muscle-derived cells genetically engineered to express BMP4. Peng, H., Usas, A., Gearhart, B., Olshanski, A., Shen, H.C., Huard, J. J. Bone Miner. Res. (2004) [Pubmed]
  31. Human dentin-matrix-derived bone morphogenetic protein. Bessho, K., Tanaka, N., Matsumoto, J., Tagawa, T., Murata, M. J. Dent. Res. (1991) [Pubmed]
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