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MeSH Review


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Disease relevance of Mandible


High impact information on Mandible

  • About 20 per cent of Smad2 heterozygous embryos have severe gastrulation defects and lack mandibles or eyes, indicating that the gene dosage of Smad2 is critical for signalling [5].
  • Dlx5 mutant mice have multiple defects in craniofacial structures, including their ears, noses, mandibles and calvaria, and die shortly after birth [6].
  • Furthermore, the nasal capsules and mandibles of the chimeras had defects similar to Gsc-null mice that varied in severity depending upon the proportion of Gsc-null cells [7].
  • Bone hydroxyapatite crystal growth in the mandibles of flight rats was preferentially altered in such a way as to reduce their size (C-axis dimension) [8].
  • The transgenic mice embryos containing -165/106-bp Msx-1 promoter-LacZ DNA in their genomes abundantly expressed beta-galactosidase in maxillae and mandibles and in the cellular primordia involved in the formation of the meninges and the bones of the skull [9].

Biological context of Mandible

  • Assays of the BSP promoter transgene in calvariae, mandibles, and tibiae of the rachitic mice showed increases in luciferase activity of 3.1-, 1.9-, and 4.6-fold, respectively, when compared with control littermates [10].
  • The proportions of double-labeled surface (dLS), the mineral apposition rate (MAR), and bone formation rate (BFR) were significantly increased in mandibles treated with the two higher doses of PGE2 [11].
  • HGF was first recognized in the mesenchymal cells of the first branchial arch at the 10th day of gestation (E10), before tongue formation, whereas HGF receptor (c-Met) -positive myogenic cells first appeared at E11 in the center of mandibles [12].
  • The present study was designed to investigate the expression of versican and ADAMTS1, 4, and 5 mRNA during bone development in rat mandibles and hind limbs by RT-PCR and in situ hybridization [13].
  • Based on the histological findings, we performed cDNA subtraction between the E10.5 and E12 mandibles to detect any differentially expressed genes which might be involved in the initiation of odontogenesis [14].

Anatomical context of Mandible


Associations of Mandible with chemical compounds

  • The synthesis of the phosphoproteins was further confirmed by the demonstration that radioactively labeled O-phosphoserine and O-phosphothreonine were identified in bone and in the EDTA-extractable phosphoproteins after pulse-labeling chick mandibles in vitro with radioactively labeled serine and threonine, respectively [20].
  • In the pups whose dams were fed the 12% protein diet with caffeine, body and mandibular weight, collagen synthesis, and hydroxyproline and calcium contents in mandibles and long bones of pups showed no difference from those of the noncaffeine group, but long bones were heavier [21].
  • These implants, together with HA and titanium plasma-sprayed implants as control materials, were placed in dog mandibles for 4 weeks [22].
  • With proper multidisciplinary pretreatment planning and postoperative treatment, osseointegrated implants can be strategically placed in patients with these reconstructed mandibles to restore occlusal and masticatory function [23].
  • Effect of essential fatty acid deficiency on the fatty acid composition and arachidonic acid levels in rat maxillae and mandibles [24].

Gene context of Mandible

  • We tested this hypothesis by conducting a whole-genome scan to detect any epistasis in FA of centroid size in the mandibles of more than 400 mice from an F2 intercross population formed from crossing the Large (LG/J) and Small (SM/J) inbred strains [25].
  • In the embryonic mandibles, resting and proliferating chondrocytes in the anterior and intermediate portions of Meckel's cartilage showed Hsp25 immunoreactivity from the 12th day of gestation (E12) through E15, whereas those in the posterior portion showed little or no immunoreactivity [26].
  • RESULTS: Mandibles implanted with carriers containing 10 microg of BMP-2 or -4 differed significantly from controls in terms of new bone area (p = 0.01 and p = 0.0001, respectively) [27].
  • These results revealed that exogenous HGF enhances bone and cartilage morphogenesis in the cultured mandibles, suggesting physiological roles for intrinsic HGF in the early development of mouse mandible [28].
  • EGF mRNA was present in mandibles at day 9 and 10 but not at days 11-17 [29].

Analytical, diagnostic and therapeutic context of Mandible


  1. Protein-energy malnutrition in rats during pregnancy modifies the effects of caffeine on fetal bones. Nakamoto, T., Shaye, R. J. Nutr. (1986) [Pubmed]
  2. Temporomandibular joint serial sections made with mandible in intercuspal position. Marguelles-Bonnet, R., Yung, J.P., Carpentier, P., Meunissier, M. Cranio : the journal of craniomandibular practice. (1989) [Pubmed]
  3. Treatment of complex mandibular fractures using titanium mesh. Schug, T., Rodemer, H., Neupert, W., Dumbach, J. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery. (2000) [Pubmed]
  4. Local application of prostaglandin E2 reduces trap, calcitonin receptor and metalloproteinase-2 immunoreactivity in the rat periodontium. Ramirez-Yañez, G.O., Seymour, G.J., Symons, A.L. Arch. Oral Biol. (2005) [Pubmed]
  5. Smad2 role in mesoderm formation, left-right patterning and craniofacial development. Nomura, M., Li, E. Nature (1998) [Pubmed]
  6. Dlx5 regulates regional development of the branchial arches and sensory capsules. Depew, M.J., Liu, J.K., Long, J.E., Presley, R., Meneses, J.J., Pedersen, R.A., Rubenstein, J.L. Development (1999) [Pubmed]
  7. Goosecoid acts cell autonomously in mesenchyme-derived tissues during craniofacial development. Rivera-Pérez, J.A., Wakamiya, M., Behringer, R.R. Development (1999) [Pubmed]
  8. Maturation of bone and dentin matrices in rats flown on the Soviet biosatellite Cosmos 1887. Simmons, D.J., Grynpas, M.D., Rosenberg, G.D. FASEB J. (1990) [Pubmed]
  9. A minimal murine Msx-1 gene promoter. Organization of its cis-regulatory motifs and their role in transcriptional activation in cells in culture and in transgenic mice. Takahashi, T., Guron, C., Shetty, S., Matsui, H., Raghow, R. J. Biol. Chem. (1997) [Pubmed]
  10. Altered expression of bone sialoproteins in vitamin D-deficient rBSP2.7Luc transgenic mice. Chen, J.J., Jin, H., Ranly, D.M., Sodek, J., Boyan, B.D. J. Bone Miner. Res. (1999) [Pubmed]
  11. Prostaglandin E2 enhances alveolar bone formation in the rat mandible. Ramirez-Yañez, G.O., Seymour, G.J., Walsh, L.J., Forwood, M.R., Symons, A.L. Bone (2004) [Pubmed]
  12. Hepatocyte growth factor is essential for migration of myogenic cells and promotes their proliferation during the early periods of tongue morphogenesis in mouse embryos. Amano, O., Yamane, A., Shimada, M., Koshimizu, U., Nakamura, T., Iseki, S. Dev. Dyn. (2002) [Pubmed]
  13. Expression of versican and ADAMTS1, 4, and 5 during bone development in the rat mandible and hind limb. Nakamura, M., Sone, S., Takahashi, I., Mizoguchi, I., Echigo, S., Sasano, Y. J. Histochem. Cytochem. (2005) [Pubmed]
  14. Detection of differentially expressed genes in the early developmental stage of the mouse mandible. Yamaza, H., Matsuo, K., Kiyoshima, T., Shigemura, N., Kobayashi, I., Wada, H., Akamime, A., Sakai, H. Int. J. Dev. Biol. (2001) [Pubmed]
  15. Tooth formation and the 28,000-dalton vitamin D-dependent calcium-binding protein: an immunocytochemical study. Taylor, A.N. J. Histochem. Cytochem. (1984) [Pubmed]
  16. Bilateral sagittal split mandibular osteotomies as an adjunct to the transoral approach to the anterior craniovertebral junction. Technical note. Vishteh, A.G., Beals, S.P., Joganic, E.F., Reiff, J.L., Dickman, C.A., Sonntag, V.K., Spetzler, R.F. J. Neurosurg. (1999) [Pubmed]
  17. Bone morphogenetic protein 4 is involved in cusp formation in molar tooth germ of mice. Tabata, M.J., Fujii, T., Liu, J.G., Ohmori, T., Abe, M., Wakisaka, S., Iwamoto, M., Kurisu, K. Eur. J. Oral Sci. (2002) [Pubmed]
  18. Immunohistochemical localization of type I collagen, fibronectin and tenascin C during embryonic osteogenesis in the dentary of mandibles and tibias in rats. Sasano, Y., Li, H.C., Zhu, J.X., Imanaka-Yoshida, K., Mizoguchi, I., Kagayama, M. Histochem. J. (2000) [Pubmed]
  19. The role of transforming growth factor alpha in rat craniofacial development and chondrogenesis. Huang, L., Solursh, M., Sandra, A. J. Anat. (1996) [Pubmed]
  20. Phosphoproteins of chicken bone matrix. Proof of synthesis in bone tissue. Glimcher, M.J., Kossiva, D., Brickley-Parsons, D. J. Biol. Chem. (1984) [Pubmed]
  21. Effects of caffeine on the growth of mandible and long bone in protein-energy malnourished newborn rats. Nakamoto, T., Shaye, R. Proc. Soc. Exp. Biol. Med. (1984) [Pubmed]
  22. Histomorphometric evaluation of the thin hydroxyapatite layer formed through anodization followed by hydrothermal treatment. Ishizawa, H., Fujino, M., Ogino, M. J. Biomed. Mater. Res. (1997) [Pubmed]
  23. Osseointegrated implants and functional prosthetic rehabilitation in microvascular fibula free flap reconstructed mandibles. Zlotolow, I.M., Huryn, J.M., Piro, J.D., Lenchewski, E., Hidalgo, D.A. Am. J. Surg. (1992) [Pubmed]
  24. Effect of essential fatty acid deficiency on the fatty acid composition and arachidonic acid levels in rat maxillae and mandibles. Alam, S.Q., Henderson, M., Alam, B.S. Calcif. Tissue Int. (1994) [Pubmed]
  25. An epistatic genetic basis for fluctuating asymmetry of mandible size in mice. Leamy, L.J., Routman, E.J., Cheverud, J.M. Evolution (2002) [Pubmed]
  26. Different expression of 25-kDa heat-shock protein (Hsp25) in Meckel's cartilage compared with other cartilages in the mouse. Shimada, M., Yamamoto, M., Wakayama, T., Iseki, S., Amano, O. Anat. Embryol. (2003) [Pubmed]
  27. Comparison of BMP-2 and -4 for rat mandibular bone regeneration at various doses. Arosarena, O., Collins, W. Orthodontics & craniofacial research. (2005) [Pubmed]
  28. Enhancement by hepatocyte growth factor of bone and cartilage formation during embryonic mouse mandibular development in vitro. Amano, O., Koshimizu, U., Nakamura, T., Iseki, S. Arch. Oral Biol. (1999) [Pubmed]
  29. Expression of epidermal growth factor mRNA in the developing mouse mandibular process. Kronmiller, J.E., Upholt, W.B., Kollar, E.J. Arch. Oral Biol. (1991) [Pubmed]
  30. Fate of bioresorbable poly(lactic acid) microbeads implanted in artificial bone defects for cortical bone augmentation in dog mandible. Anselme, K., Flautre, B., Hardouin, P., Chanavaz, M., Ustariz, C., Vert, M. Biomaterials (1993) [Pubmed]
  31. Clinical evaluation of overdenture restorations supported by osseointegrated titanium implants: a retrospective study. Mericske-Stern, R. The International journal of oral & maxillofacial implants. (1990) [Pubmed]
  32. Changes in mineral content, mineral deposition and vascular supply of the mandible after osteotomy. Nilsson, L.P., Granström, G., Röckert, H.O. Scandinavian journal of plastic and reconstructive surgery and hand surgery / Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi. (1988) [Pubmed]
  33. Concentrations of clindamycin in the mandibular bone of companion animals. Zetner, K., Schmidt, H., Pfeiffer, S. Vet. Ther. (2003) [Pubmed]
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