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Is frequent dosing with ecstasy a risky business for dopamine-containing neurons?

Over the past 20 years 3,4-methylenedioxymethamphetamine (MDMA; also known as 'ecstasy') has become a widely used recreational drug of abuse. However, studies have indicated that it is neurotoxic to serotonergic nerve terminals in rats and non-human primates and dopaminergic nerve terminals in mice. Recently, this tenet has been questioned following a study suggesting that MDMA can cause toxicity to dopamine-containing neurons in monkeys. In this article, the factors contributing to this change in neurotoxic profile are discussed.[1]

References

  1. Is frequent dosing with ecstasy a risky business for dopamine-containing neurons? O'Shea, E., Colado, M.I. Trends Pharmacol. Sci. (2003) [Pubmed]
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