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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The prognostic impact of clinical and CT parameters in patients with pontine hemorrhage.

BACKGROUND: In patients with pontine hemorrhage (PH), an accurate prognostic assessment is critical for establishing a reasonable therapeutic approach. METHODS: The initial clinical symptoms and computed tomography (CT) features were analyzed with multivariate regression analysis in 39 consecutive patients with PH. PHs were classified into three types: (1) large paramedian, (2) basal or basotegmental and (3) lateral tegmental, and the hematomas' diameters were measured. The patients' outcome was evaluated. RESULTS: Twenty-seven patients (69%) died and 12 (31%) survived for more than 1 year after PH. The symptom most predictive of death was coma on admission. The large paramedian type of PH predicted a poor prognosis, whereas the lateral tegmental type was associated with a favorable outcome. The transverse hematoma diameter was also related to outcome, with the threshold value found to be 20 mm. CONCLUSIONS: We conclude that PH outcome can be estimated best by combining the CT parameters 'large paramedian PH' and 'transverse diameter >/=20 mm' with the clinical variable 'coma on admission'. Survival is unlikely if all 3 features are present, whereas survival may be expected if only 1 or none of these features is found.[1]


  1. The prognostic impact of clinical and CT parameters in patients with pontine hemorrhage. Dziewas, R., Kremer, M., Lüdemann, P., Nabavi, D.G., Dräger, B., Ringelstein, B. Cerebrovasc. Dis. (2003) [Pubmed]
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