Disease relevance of Hematoma

• Two CT variables (IVH and hematoma volume) that differed in these two hemorrhage groups were important predictors of coma (GCS less than or equal to 8) in a logistic regression model [1].
• Input variables were age, gender, race, hydrocephalus, mean arterial pressure, pulse pressure, Glasgow Coma Scale score, intraventricular hemorrhage, hydrocephalus, hematoma size, hematoma location (ganglionic, thalamic, or lobar), cisternal effacement, pineal shift, history of hypertension, history of diabetes, and age [2].
• Stepwise multiple regression analysis gave four independent predictors of the first-day MAP: hypertension, age (in an inverse fashion), admission blood glucose, and hematoma volume [3].
• Treatment with a matrix metalloproteinase inhibitor, BB-1101, was begun 6 hours after the collagenase lesion, when the hematomas were formed and the secondary edema was increasing [4].
• We investigated whether early hematoma or edema volumes could explain the adverse association between APOE epsilon4 and survival in intracerebral hemorrhage [5].

Psychiatry related information on Hematoma

• We report a case of intracavernous hematoma, penile curvature deformity and Peyronie's-like plaque that developed after initiating intracorporeal self-injection of prostaglandin E1 for erectile dysfunction [6].

High impact information on Hematoma

• Fatal hematoma during treatment with adjusted-dose subcutaneous heparin therapy [7].
• In those having hip arthroplasty, LMWH was as effective as low-intensity warfarin therapy, but its use was associated with more wound hematomas [8].
• Apoptosis was approximately 50% decreased in the area immediately surrounding the hematoma and was associated with a similar inhibition of caspase activity [9].
• Immunohistochemistry showed MMP-12 to be localized in activated monocytoid cells surrounding the hematoma [10].
• ICH increased brain MMP-2, -3, -7, and -9 mRNA levels relative to sham-injected (control) animals in the vicinity of the hematoma, but MMP-12 (macrophage metalloelastase) was the most highly induced MMP (>80-fold) [10].

Chemical compound and disease context of Hematoma

• Technetium 99m/sulfur colloid scanning of the spleen during the acute splenic sequestration crises in three patients showed almost total lack of splenic uptake or decreased uptake with intrasplenic filling defects thought to be splenic infarcts or hematomas on follow-up computed tomographic scanning [11].
• Risk factors for the development of retroperitoneal hematoma after percutaneous coronary intervention in the era of glycoprotein IIb/IIIa inhibitors and vascular closure devices [12].
• The radiographic features most likely to resolve were stenosis and mural hematoma, while occlusion and luminal irregularity tended to persist [13].
• We froze brains in situ at 1, 3, 5, and 8 hours after hematoma induction and cut coronal sections of hematoma assessment, morphological brain examination, and immunohistochemical and water content determinations [14].
• After smoking "crack" cocaine and consuming large quantities of ethanol, a 36-year-old man developed multiple, bilateral, deep, and superficial cerebral hematomas [15].

Biological context of Hematoma

• In the vasoproliferative stages of mature infarction, MAP elevation induced by a cerebral vasoconstrictor caused hemorrhagic infarctions while cerebral vasodilation caused intracerebral hematomas [16].
• Cerebral hematoma enhances vasoconstriction induced by topical application of the vasoconstrictor agents endothelin-1 (ET-1) and leukotriene C4 (LTC4) [17].
• An acquired circulating inhibitor to Factor VIII:C was found in a 27-year-old postpartum woman who presented with ecchymoses and hematomas [18].
• Fracture healing begins immediately following injury, when growth factors, including TGF-beta 1 and PDGF, are released into the fracture hematoma by platelets and inflammatory cells [19].
• In contrast, significant differences were seen between the two subgroups in trauma-to-operation interval, hematoma volume, CT hematoma density (mixed low-high CT density vs. homogeneous hyperdensity), midline displacement, severity of associated intracranial lesions, and postoperative intracranial pressure (ICP) [20].

Anatomical context of Hematoma

• Although hematomas of the rectus abdominis muscle are commonly reported complications of systemic anticoagulation treatment, they are a rare complication of prophylactic administration of low-dose heparin [21].
• CONCLUSIONS: Central benzodiazepine receptor-[123I]iomazenil binding was decreased in the ipsilateral cerebral cortex remote from the subcortical hematoma [22].
• Shed blood cells per se produce lactate and pyruvate, and blood in the subarachnoid space and intracerebral hematomas cause secondary changes in brain tissue metabolism by a probable reduction of cerebral blood flow [23].
• Indium-111-labeled leukocyte localization in hematomas: a pitfall in abscess detection [24].
• Of these 39 women, 20 had a tubal hematoma and six had a ruptured fallopian tube [25].

Gene context of Hematoma

• The results suggest that the hematoma cells are the primary source of VEGF [26].
• A marked increase in the expression of ANG-2 mRNA over ANG-1 mRNA demonstrates a pro-angiogenic pattern in the hematoma membranes [26].
• Production of interleukin-10 in human fracture soft-tissue hematomas [27].
• Administration of exogenous CNTF into the lesion following initiation of ICH resulted in a prolonged expression of CNTFR-alpha on cortical neurons neighboring the hematoma [28].
• Further, CNTFR-alpha was transiently expressed in the cerebral cortex surrounding the hematoma, with a peak at 5 days [28].

Analytical, diagnostic and therapeutic context of Hematoma

• CONCLUSIONS: Intravenous heparin initiation 6 h or 24 h after pacemaker or defibrillator implantation is associated with a 20% prevalence of pocket hematoma formation [29].
• Thigh hematoma after femoral venipuncture in a patient treated with low-molecular-weight heparin [30].
• A small hematoma (less than 5.0 cm) after ambulation occurred early (from compression to standing) in 14 patients (5%; 9 received heparin, 8 were taking aspirin) and later (after standing to 72 h) in 9 patients (3%; 2 receiving heparin, 2 taking aspirin) [31].
• Median time to surgery was 180 minutes; median hematoma volume was 40 mL; median baseline NIH Stroke Scale score was 19 and Glasgow Coma Scale score was 12 [32].
• A 24-year-old woman with a left pontine hematoma showed marked asymmetry in the EEG of REM sleep, suggesting that a unilateral pontine lesion is sufficient to disrupt normal REM sleep EEG in the ipsilateral hemisphere [33].

References