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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Hematoma


Psychiatry related information on Hematoma


High impact information on Hematoma

  • Fatal hematoma during treatment with adjusted-dose subcutaneous heparin therapy [7].
  • In those having hip arthroplasty, LMWH was as effective as low-intensity warfarin therapy, but its use was associated with more wound hematomas [8].
  • Apoptosis was approximately 50% decreased in the area immediately surrounding the hematoma and was associated with a similar inhibition of caspase activity [9].
  • Immunohistochemistry showed MMP-12 to be localized in activated monocytoid cells surrounding the hematoma [10].
  • ICH increased brain MMP-2, -3, -7, and -9 mRNA levels relative to sham-injected (control) animals in the vicinity of the hematoma, but MMP-12 (macrophage metalloelastase) was the most highly induced MMP (>80-fold) [10].

Chemical compound and disease context of Hematoma

  • Technetium 99m/sulfur colloid scanning of the spleen during the acute splenic sequestration crises in three patients showed almost total lack of splenic uptake or decreased uptake with intrasplenic filling defects thought to be splenic infarcts or hematomas on follow-up computed tomographic scanning [11].
  • Risk factors for the development of retroperitoneal hematoma after percutaneous coronary intervention in the era of glycoprotein IIb/IIIa inhibitors and vascular closure devices [12].
  • The radiographic features most likely to resolve were stenosis and mural hematoma, while occlusion and luminal irregularity tended to persist [13].
  • We froze brains in situ at 1, 3, 5, and 8 hours after hematoma induction and cut coronal sections of hematoma assessment, morphological brain examination, and immunohistochemical and water content determinations [14].
  • After smoking "crack" cocaine and consuming large quantities of ethanol, a 36-year-old man developed multiple, bilateral, deep, and superficial cerebral hematomas [15].

Biological context of Hematoma


Anatomical context of Hematoma


Gene context of Hematoma


Analytical, diagnostic and therapeutic context of Hematoma

  • CONCLUSIONS: Intravenous heparin initiation 6 h or 24 h after pacemaker or defibrillator implantation is associated with a 20% prevalence of pocket hematoma formation [29].
  • Thigh hematoma after femoral venipuncture in a patient treated with low-molecular-weight heparin [30].
  • A small hematoma (less than 5.0 cm) after ambulation occurred early (from compression to standing) in 14 patients (5%; 9 received heparin, 8 were taking aspirin) and later (after standing to 72 h) in 9 patients (3%; 2 receiving heparin, 2 taking aspirin) [31].
  • Median time to surgery was 180 minutes; median hematoma volume was 40 mL; median baseline NIH Stroke Scale score was 19 and Glasgow Coma Scale score was 12 [32].
  • A 24-year-old woman with a left pontine hematoma showed marked asymmetry in the EEG of REM sleep, suggesting that a unilateral pontine lesion is sufficient to disrupt normal REM sleep EEG in the ipsilateral hemisphere [33].


  1. Clinical discriminators of lobar and deep hemorrhages: the Stroke Data Bank. Massaro, A.R., Sacco, R.L., Mohr, J.P., Foulkes, M.A., Tatemichi, T.K., Price, T.R., Hier, D.B., Wolf, P.A. Neurology (1991) [Pubmed]
  2. Artificial neural networks improve the prediction of mortality in intracerebral hemorrhage. Edwards, D.F., Hollingsworth, H., Zazulia, A.R., Diringer, M.N. Neurology (1999) [Pubmed]
  3. Prognostic value and determinants of first-day mean arterial pressure in spontaneous supratentorial intracerebral hemorrhage. Fogelholm, R., Avikainen, S., Murros, K. Stroke (1997) [Pubmed]
  4. Metalloproteinase inhibition blocks edema in intracerebral hemorrhage in the rat. Rosenberg, G.A., Navratil, M. Neurology (1997) [Pubmed]
  5. Intracerebral hemorrhage outcome: apolipoprotein E genotype, hematoma, and edema volumes. McCarron, M.O., Hoffmann, K.L., DeLong, D.M., Gray, L., Saunders, A.M., Alberts, M.J. Neurology (1999) [Pubmed]
  6. Peyronie's-like plaque after penile injection of prostaglandin E1. Chen, J., Godschalk, M., Katz, P.G., Mulligan, T. J. Urol. (1994) [Pubmed]
  7. Fatal hematoma during treatment with adjusted-dose subcutaneous heparin therapy. Gabel, A., Müller, S. N. Engl. J. Med. (1999) [Pubmed]
  8. Low molecular weight heparin: a critical analysis of clinical trials. Green, D., Hirsh, J., Heit, J., Prins, M., Davidson, B., Lensing, A.W. Pharmacol. Rev. (1994) [Pubmed]
  9. Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats. Rodrigues, C.M., Sola, S., Nan, Z., Castro, R.E., Ribeiro, P.S., Low, W.C., Steer, C.J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  10. Intracerebral hemorrhage induces macrophage activation and matrix metalloproteinases. Power, C., Henry, S., Del Bigio, M.R., Larsen, P.H., Corbett, D., Imai, Y., Yong, V.W., Peeling, J. Ann. Neurol. (2003) [Pubmed]
  11. Acute splenic sequestration crises in adults with sickle cell disease. Solanki, D.L., Kletter, G.G., Castro, O. Am. J. Med. (1986) [Pubmed]
  12. Risk factors for the development of retroperitoneal hematoma after percutaneous coronary intervention in the era of glycoprotein IIb/IIIa inhibitors and vascular closure devices. Farouque, H.M., Tremmel, J.A., Raissi Shabari, F., Aggarwal, M., Fearon, W.F., Ng, M.K., Rezaee, M., Yeung, A.C., Lee, D.P. J. Am. Coll. Cardiol. (2005) [Pubmed]
  13. Magnetic resonance angiography demonstrates vascular healing of carotid and vertebral artery dissections. Kasner, S.E., Hankins, L.L., Bratina, P., Morgenstern, L.B. Stroke (1997) [Pubmed]
  14. Lobar intracerebral hemorrhage model in pigs: rapid edema development in perihematomal white matter. Wagner, K.R., Xi, G., Hua, Y., Kleinholz, M., de Courten-Myers, G.M., Myers, R.E., Broderick, J.P., Brott, T.G. Stroke (1996) [Pubmed]
  15. Multiple intracerebral hemorrhages after smoking "crack" cocaine. Green, R.M., Kelly, K.M., Gabrielsen, T., Levine, S.R., Vanderzant, C. Stroke (1990) [Pubmed]
  16. Primate model of cerebral hematoma. Laurent, J.P., Molinari, G.F., Oakley, J.C. J. Neuropathol. Exp. Neurol. (1976) [Pubmed]
  17. Hematoma-induced enhanced cerebral vasoconstrictions to leukotriene C4 and endothelin-1 in piglets: role of prostanoids. Yakubu, M.A., Shibata, M., Leffler, C.W. Pediatr. Res. (1995) [Pubmed]
  18. Postpartum hemophilia. Shitamoto, B.S., Leslie, K.O., Galloway, W.B. Am. J. Clin. Pathol. (1982) [Pubmed]
  19. Regulation of fracture repair by growth factors. Bolander, M.E. Proc. Soc. Exp. Biol. Med. (1992) [Pubmed]
  20. Extradural hematoma: analysis of factors influencing the courses of 161 patients. Rivas, J.J., Lobato, R.D., Sarabia, R., Cordobés, F., Cabrera, A., Gomez, P. Neurosurgery (1988) [Pubmed]
  21. Low-dose heparin. A cause of hematoma of rectus abdominis. Tsapatsaris, N.P. Arch. Intern. Med. (1991) [Pubmed]
  22. Central benzodiazepine receptor distribution after subcortical hemorrhage evaluated by means of [123I]iomazenil and SPECT. Hatazawa, J., Shimosegawa, E., Satoh, T., Kanno, I., Uemura, K. Stroke (1995) [Pubmed]
  23. Lactate and pyruvate concentrations, and acid-base balance of cerebrospinal fluid in experimentally induced intracerebral and subarachnoid hemorrhage in dogs. Sugi, T., Fujishima, M., Omae, T. Stroke (1975) [Pubmed]
  24. Indium-111-labeled leukocyte localization in hematomas: a pitfall in abscess detection. Wing, V.W., vanSonnenberg, E., Kipper, S., Bieberstein, M.P. Radiology. (1984) [Pubmed]
  25. Can the status of tubal pregnancy be predicted with transvaginal sonography? A prospective comparison of sonographic, surgical, and serum hCG findings. Cacciatore, B. Radiology. (1990) [Pubmed]
  26. Increased mRNA expression of VEGF within the hematoma and imbalance of angiopoietin-1 and -2 mRNA within the neomembranes of chronic subdural hematoma. Hohenstein, A., Erber, R., Schilling, L., Weigel, R. J. Neurotrauma (2005) [Pubmed]
  27. Production of interleukin-10 in human fracture soft-tissue hematomas. Hauser, C.J., Joshi, P., Zhou, X., Kregor, P., Hardy, K.J., Devidas, M., Scott, P., Hughes, J.L. Shock (1996) [Pubmed]
  28. Expression of ciliary neurotrophic factor (CNTF), CNTF receptor alpha (CNTFR-alpha) following experimental intracerebral hemorrhage in rats. Yokota, H., Yoshikawa, M., Hirabayashi, H., Nakase, H., Uranishi, R., Nishimura, F., Sugie, Y., Ishizaka, S., Sakaki, T. Neurosci. Lett. (2005) [Pubmed]
  29. A randomized trial comparing heparin initiation 6 h or 24 h after pacemaker or defibrillator implantation. Michaud, G.F., Pelosi, F., Noble, M.D., Knight, B.P., Morady, F., Strickberger, S.A. J. Am. Coll. Cardiol. (2000) [Pubmed]
  30. Thigh hematoma after femoral venipuncture in a patient treated with low-molecular-weight heparin. Kumar, P.D., Solti, M. Arch. Intern. Med. (2001) [Pubmed]
  31. Early ambulation after 5 French diagnostic cardiac catheterization: results of a multicenter trial. Kern, M.J., Cohen, M., Talley, J.D., Litvack, F., Serota, H., Aguirre, F., Deligonul, U., Bashore, T.M. J. Am. Coll. Cardiol. (1990) [Pubmed]
  32. Rebleeding leads to poor outcome in ultra-early craniotomy for intracerebral hemorrhage. Morgenstern, L.B., Demchuk, A.M., Kim, D.H., Frankowski, R.F., Grotta, J.C. Neurology (2001) [Pubmed]
  33. Cortical asymmetry of REM sleep EEG following unilateral pontine hemorrhage. Kushida, C.A., Rye, D.B., Nummy, D., Milton, J.G., Spire, J.P., Rechtschaffen, A. Neurology (1991) [Pubmed]
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