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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The shared tumor-associated antigen cytochrome P450 1B1 is recognized by specific cytotoxic T cells.

Cytochrome P450 1B1 (CYP1B1), a drug-metabolizing extrahepatic enzyme, was recently shown to be overexpressed in multiple types of cancer. Such tumor-associated genes may be useful targets for anticancer therapy, particularly cancer immunotherapeutics. We identified HLA-A*0201-binding peptides and a naturally processed and presented T-cell epitope capable of inducing CYP1B1-specific cytotoxic T lymphocytes (CTLs) in HLA-A2 transgenic mice. Furthermore, the induction of CYP1B1-specific T cells was demonstrated in healthy donors and cancer patients. These T cells efficiently lysed target cells pulsed with the cognate peptide. More important, HLA-A2-matched tumor cell lines and primary malignant cells were also recognized by CYP1B1-specific CTLs. These findings form the basis of a phase 1 clinical trial exploring a DNA-based vector encoding CYP1B1 for widely applicable cancer immunotherapy conducted at the Dana-Farber Cancer Institute.[1]


  1. The shared tumor-associated antigen cytochrome P450 1B1 is recognized by specific cytotoxic T cells. Maecker, B., Sherr, D.H., Vonderheide, R.H., von Bergwelt-Baildon, M.S., Hirano, N., Anderson, K.S., Xia, Z., Butler, M.O., Wucherpfennig, K.W., O'Hara, C., Cole, G., Kwak, S.S., Ramstedt, U., Tomlinson, A.J., Chicz, R.M., Nadler, L.M., Schultze, J.L. Blood (2003) [Pubmed]
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