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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Indels in protein-coding sequences of Euarchontoglires constrain the rooting of the eutherian tree.

Despite the availability of large molecular data sets, the position of the root of the eutherian tree remains a controversial issue. Depending on source data, taxon sampling and analytical approach, the root can be placed at either Afrotheria, Xenarthra, Afrotheria+Xenarthra, or murid rodents. We explored the phylogenetic potential of indels in four nuclear protein-coding genes (SCA1, PRNP, TNFalpha, and HspB3) with regard to a possible rooting at the murid branch. According to parsimony principles, five indels were interpreted to contradict such a rooting, and one indel to support it. The results illustrate that indels, despite the occurrence of homoplasy, can be convincing sources of independent molecular evidence to distinguish between alternative phylogenetic hypotheses.[1]

References

  1. Indels in protein-coding sequences of Euarchontoglires constrain the rooting of the eutherian tree. de Jong, W.W., van Dijk, M.A., Poux, C., Kappé, G., van Rheede, T., Madsen, O. Mol. Phylogenet. Evol. (2003) [Pubmed]
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