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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

The Product of the fimI gene is necessary for Escherichia coli type 1 pilus biosynthesis.

Site-directed mutagenesis was employed to create lesions in fimI, a gene of uncertain function located in the chromosomal gene cluster (fim) involved in Escherichia coli type 1 pilus biosynthesis. Chromosomal fimI mutations produced a piliation-negative phenotype. Complementation analysis indicated that a fimI'-kan insertion mutation and a fimI frameshift mutation produced polarity-like effects not seen with an in-frame fimI deletion mutation. Minicell analysis associated fimI with a 16.4-kDa noncytoplasmic protein product (FimI). We conclude that FimI has a required role in normal pilus biosynthesis.[1]

References

  1. The Product of the fimI gene is necessary for Escherichia coli type 1 pilus biosynthesis. Valenski, M.L., Harris, S.L., Spears, P.A., Horton, J.R., Orndorff, P.E. J. Bacteriol. (2003) [Pubmed]
 
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