- PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains. Möller, A., Sirma, H., Hofmann, T.G., Rueffer, S., Klimczak, E., Dröge, W., Will, H., Schmitz, M.L. Cancer Res. (2003)