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Miura, H. et al.

Miura, Kusakabe, Kato, Miura-Ohnuma, Tagami, Ninomiya, Hino,

Co-expression pattern of Shh with Prox1 and that of Nkx2.2 with Mash1 in mouse taste bud.

In mammals, taste buds are maintained by continuous turnover of cells, even in adulthood. Cell proliferation and differentiation continue to produce taste cells, which express various genes related to taste reception. We found the co-expression of Sonic hedgehog (Shh) with Prox1 and that of Nkx2.2 with Mash1 in adult mouse taste buds. Whereas Prox1was expressed strongly in cells in the basal region of mouse taste buds where Shh was co-expressed, it was expressed weakly in almost all taste bud cells lacking Shh expression. At 0.5 day after birth, when taste cells have not yet differentiated, the expressions of Shh and Prox1 completely overlapped in the epithelium of circumvallate papillae. Nkx2.2 was observed in cells expressing Mash1, but not in cells expressing genes related to taste reception, such as gustducin and T1R3. Almost all fusiform cells expressing Mash1 co-expressed Nkx2.2, while the majority of round cells expressing Mash1 in the basal region of taste buds lacked Nkx2.2 expression.[1]

References

Co-expression pattern of Shh with Prox1 and that of Nkx2.2 with Mash1 in mouse taste bud. Miura, H., Kusakabe, Y., Kato, H., Miura-Ohnuma, J., Tagami, M., Ninomiya, Y., Hino, A. Gene Expr. Patterns (2003) [Pubmed]

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