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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Giles, F.J. et al.

Giles, Feldman, Roboz, Larson, Mamus, Cortes, Verstovsek, Faderl, Talpaz, Beran, Albitar, O'Brien, Kantarjian,

Phase II study of troxacitabine, a novel dioxolane nucleoside analog, in patients with untreated or imatinib mesylate-resistant chronic myelogenous leukemia in blastic phase.

A phase II study of troxacitabine, a non-natural dioxolane nucleoside L-enantiomer, was conducted in patients with chronic myelogenous leukemia in blastic phase (CML-BP). Patients were untreated for BP, or treated with imatinib mesylate (IM) as sole prior therapy for BP. Troxacitabine was given as an intravenous infusion over 30 min daily for 5 days at a dose of 8.0 mg/m(2) per day. Thirty-one patients, 29 (93%) of whom had failed prior IM therapy, received 51 courses of therapy. Grade 3 or 4 toxicities included stomatitis (4%), hand-foot syndrome (18%), and skin rash (12%). Four patients (13%) responded. Troxacitabine-based combinations merit study in IM-resistant CML.[1]

References

Phase II study of troxacitabine, a novel dioxolane nucleoside analog, in patients with untreated or imatinib mesylate-resistant chronic myelogenous leukemia in blastic phase. Giles, F.J., Feldman, E.J., Roboz, G.J., Larson, R.A., Mamus, S.W., Cortes, J.E., Verstovsek, S., Faderl, S., Talpaz, M., Beran, M., Albitar, M., O'Brien, S.M., Kantarjian, H.M. Leuk. Res. (2003) [Pubmed]

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