The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Exanthema

  • With ticlopidine, diarrhea (20 percent), skin rash (14 percent), and severe but reversible neutropenia (less than 1 percent) were noted [1].
  • Hyperimmunoglobulinaemia D and periodic fever syndrome (HIDS; MIM 260920) is an autosomal recessive disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash [2].
  • The CD8+ cytotoxic T lymphocyte (CTL) lines isolated from the skin rash in one patient exhibited a specific, class I MHC-restricted cytotoxic activity against HIV-1 Gag- and Pol-expressing target cells, whereas CTL lines derived from the skin lesions of a second patient were shown to be predominantly Env-specific [3].
  • When mesalazine was instituted 1 week later, she developed a severe hypersensitivity reaction characterized by fever, diarrhea, skin rash with subsequent desquamation, marked atypical lymphocytosis, and severe hepatotoxicity [4].
  • These findings suggest that the skin rash associated with a glucagonoma is most likely due to an amino acid deficiency and can be reversed by parenteral nutrition [5].

Psychiatry related information on Exanthema


High impact information on Exanthema


Chemical compound and disease context of Exanthema


Biological context of Exanthema


Anatomical context of Exanthema


Gene context of Exanthema

  • The VEGF levels at the appearance of skin rash and/or edema of hands and feet were also elevated to 176+/-163 pg/ml (p <0.001) [27].
  • In comparison with normal skin, immunoreactivity for IL-5 and all the chemokines was also significantly enhanced in drug-induced exanthem, whereas significant differences in psoriatic were only observed for IL-5 and eotaxin [28].
  • Within the B19 infected group, the TGF beta 1 +869 T allele was associated with skin rash at acute infection (p = 0.005), whereas at follow up the IFN-gamma +874 T allele was associated with the development of anti-B19 non-structural protein 1 antibodies (p = 0.04) [29].
  • The most common side effect of anti-EGFR treatment is an acneiform skin rash, which is associated with the clinical outcome of treatment with monoclonal antibodies and TK inhibitors [30].
  • Treatment with SCF plus filgrastim was well tolerated, with mild to moderate local skin rash being the most frequently reported adverse event [31].

Analytical, diagnostic and therapeutic context of Exanthema


  1. A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients. Ticlopidine Aspirin Stroke Study Group. Hass, W.K., Easton, J.D., Adams, H.P., Pryse-Phillips, W., Molony, B.A., Anderson, S., Kamm, B. N. Engl. J. Med. (1989) [Pubmed]
  2. Mutations in MVK, encoding mevalonate kinase, cause hyperimmunoglobulinaemia D and periodic fever syndrome. Houten, S.M., Kuis, W., Duran, M., de Koning, T.J., van Royen-Kerkhof, A., Romeijn, G.J., Frenkel, J., Dorland, L., de Barse, M.M., Huijbers, W.A., Rijkers, G.T., Waterham, H.R., Wanders, R.J., Poll-The, B.T. Nat. Genet. (1999) [Pubmed]
  3. Oligoclonal expansion of HIV-specific cytotoxic CD8 T lymphocytes in the skin of HIV-1-infected patients with cutaneous pseudolymphoma. Bachelez, H., Hadida, F., Parizot, C., Flageul, B., Kemula, M., Dubertret, L., Debree, P., Gorochov, G. J. Clin. Invest. (1998) [Pubmed]
  4. Hypersensitivity with hepatotoxicity to mesalazine after hypersensitivity to sulfasalazine. Hautekeete, M.L., Bourgeois, N., Potvin, P., Duville, L., Reynaert, H., Devis, G., Adler, M., Klöppel, G. Gastroenterology (1992) [Pubmed]
  5. Amino acid deficiency and the skin rash associated with glucagonoma. Norton, J.A., Kahn, C.R., Schiebinger, R., Gorschboth, C., Brennan, M.F. Ann. Intern. Med. (1979) [Pubmed]
  6. Tolerability of long-term prophylaxis with fansidar: a randomized double-blind study in Nigeria. Stemberger, H., Leimer, R., Wiedermann, G. Acta Trop. (1984) [Pubmed]
  7. Respiratory infections: clinical experiences with the new quinolones. Davies, B.I., Maesen, F.P. Pharmaceutisch weekblad. Scientific edition. (1987) [Pubmed]
  8. Occurrence of exanthema in relation to aminopenicillin preparations and allopurinol. Hoigné, R., Sonntag, M.R., Zoppi, M., Hess, T., Maibach, R., Fritschy, D. N. Engl. J. Med. (1987) [Pubmed]
  9. Suppression of carbamazepine-induced skin rash with prednisone. Vick, N.A. N. Engl. J. Med. (1983) [Pubmed]
  10. Skin rash associated with Sinemet 25/100. Goetz, C.G. N. Engl. J. Med. (1983) [Pubmed]
  11. Sulfasalazine toxic reactions. Hepatitis, fever, and skin rash with hypocomplementemia and immune complexes. Mihas, A.A., Goldenberg, D.J., Slaughter, R.L. JAMA (1978) [Pubmed]
  12. Olsalazine sodium in the treatment of ulcerative colitis among patients intolerant of sulfasalazine. A prospective, randomized, placebo-controlled, double-blind, dose-ranging clinical trial. Meyers, S., Sachar, D.B., Present, D.H., Janowitz, H.D. Gastroenterology (1987) [Pubmed]
  13. A phase I study of continuous infusion 5-fluorouracil plus calcium leucovorin in combination with N-(phosphonacetyl)-L-aspartate in metastatic gastrointestinal adenocarcinoma. Grem, J.L., McAtee, N., Steinberg, S.M., Hamilton, J.M., Murphy, R.F., Drake, J., Chisena, T., Balis, F., Cysyk, R., Arbuck, S.G. Cancer Res. (1993) [Pubmed]
  14. Phase II study of troxacitabine (BCH-4556) in patients with advanced and/or metastatic renal cell carcinoma: a trial of the National Cancer Institute of Canada-Clinical Trials Group. Townsley, C.A., Chi, K., Ernst, D.S., Belanger, K., Tannock, I., Bjarnason, G.A., Stewart, D., Goel, R., Ruether, J.D., Siu, L.L., Jolivet, J., McIntosh, L., Seymour, L., Moore, M.J. J. Clin. Oncol. (2003) [Pubmed]
  15. Local skin rash after intraarticular methyl prednisolone acetate injection in a patient with rheumatoid arthritis. Konttinen, Y.T., Friman, C., Tolvanen, E., Reitamo, S., Johansson, E. Arthritis Rheum. (1983) [Pubmed]
  16. Enalapril worldwide experience. Davies, R.O., Irvin, J.D., Kramsch, D.K., Walker, J.F., Moncloa, F. Am. J. Med. (1984) [Pubmed]
  17. Predictors of rapid progression to AIDS in HIV-1 seroconverters. Keet, I.P., Krijnen, P., Koot, M., Lange, J.M., Miedema, F., Goudsmit, J., Coutinho, R.A. AIDS (1993) [Pubmed]
  18. Autoimmune progesterone dermatitis. Teelucksingh, S., Edwards, C.R. J. Intern. Med. (1990) [Pubmed]
  19. Skin rash and bronchoalveolar histology correlates with clinical benefit in patients treated with gefitinib as a therapy for previously treated advanced or metastatic non-small cell lung cancer. Dudek, A.Z., Kmak, K.L., Koopmeiners, J., Keshtgarpour, M. Lung Cancer (2006) [Pubmed]
  20. Role of drug metabolism for breaking tolerance and the localization of drug hypersensitivity. Uetrecht, J. Toxicology (2005) [Pubmed]
  21. A reverse transcription-nested PCR assay for HHV-6 mRNA early transcript detection after transplantation. Pradeau, K., Bordessoule, D., Szelag, J.C., Rolle, F., Ferrat, P., Meur, Y.L., Turlure, P., Denis, F., Ranger-Rogez, S. J. Virol. Methods (2006) [Pubmed]
  22. Single-blind comparative study of nabumetone (Relafen) versus naproxen in the treatment of rheumatoid arthritis. Hazleman, B.L., Thomas, P.P. Am. J. Med. (1987) [Pubmed]
  23. Infiltration of cytotoxic T cells in drug-induced cutaneous eruptions. Yawalkar, N., Egli, F., Hari, Y., Nievergelt, H., Braathen, L.R., Pichler, W.J. Clin. Exp. Allergy (2000) [Pubmed]
  24. Pathogenesis of drug-induced exanthema. Yawalkar, N., Pichler, W.J. Int. Arch. Allergy Immunol. (2001) [Pubmed]
  25. In vitro drug allergy detection system incorporating human liver microsomes in chlorazepate-induced skin rash: drug-specific proliferation associated with interleukin-5 secretion. Sachs, B., Erdmann, S., Al-Masaoudi, T., Merk, H.F. Br. J. Dermatol. (2001) [Pubmed]
  26. Bone marrow aplasia and severe skin rash after a single low dose of methotrexate. Copur, S., Dahut, W., Chu, E., Allegra, C.J. Anticancer Drugs (1995) [Pubmed]
  27. Vascular endothelial growth factor in acute Kawasaki disease. Terai, M., Yasukawa, K., Narumoto, S., Tateno, S., Oana, S., Kohno, Y. Am. J. Cardiol. (1999) [Pubmed]
  28. Evidence for a role for IL-5 and eotaxin in activating and recruiting eosinophils in drug-induced cutaneous eruptions. Yawalkar, N., Shrikhande, M., Hari, Y., Nievergelt, H., Braathen, L.R., Pichler, W.J. J. Allergy Clin. Immunol. (2000) [Pubmed]
  29. Cytokine gene polymorphisms associated with symptomatic parvovirus B19 infection. Kerr, J.R., McCoy, M., Burke, B., Mattey, D.L., Pravica, V., Hutchinson, I.V. J. Clin. Pathol. (2003) [Pubmed]
  30. Epidermal growth factor receptor as a target for chemotherapy. Vallbohmer, D., Lenz, H.J. Clinical colorectal cancer. (2005) [Pubmed]
  31. Mobilization of peripheral blood progenitor cells with a combination of cyclophosphamide, r-metHuSCF and filgrastim in patients with breast cancer previously treated with chemotherapy. Prósper, F., Solá, C., Hornedo, J., Arbona, C., Menéndez, P., Orfao, A., Lluch, A., Cortés-Funes, H., López, J.J., García-Conde, J. Leukemia (2003) [Pubmed]
  32. The Schnitzler syndrome. Four new cases and review of the literature. Lipsker, D., Veran, Y., Grunenberger, F., Cribier, B., Heid, E., Grosshans, E. Medicine (Baltimore) (2001) [Pubmed]
  33. Icodextrin: a review of its use in peritoneal dialysis. Frampton, J.E., Plosker, G.L. Drugs (2003) [Pubmed]
  34. Characterization of the cutaneous exanthem in macaques infected with a Nef gene variant of SIVmac239. Sasseville, V.G., Rottman, J.B., Du, Z., Veazey, R., Knight, H.L., Caunt, D., Desrosiers, R.C., Lackner, A.A. J. Invest. Dermatol. (1998) [Pubmed]
  35. Ticlopidine. A review of its pharmacology, clinical efficacy and tolerability in the prevention of cerebral ischaemia and stroke. Noble, S., Goa, K.L. Drugs & aging. (1996) [Pubmed]
WikiGenes - Universities