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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Mast cell-dependent migration of effector CD8+ T cells through production of leukotriene B4.

Studies in both humans and rodents indicate that CD8+ T cells may be important in allergic inflammation. However, neither the mechanisms that mediate CD8+ T cell recruitment to inflamed tissues nor the relative participation of effector and central memory CD8+ T cells is known. Here we report that activated mast cells induced chemotaxis of effector, but not central memory, CD8+ T cells through production of leukotriene B4 (LTB4). These studies indicate that LTB4 production by activated peripheral leukocytes could be important for the recruitment of effector CD8+ T cells to sites of inflammation.[1]

References

  1. Mast cell-dependent migration of effector CD8+ T cells through production of leukotriene B4. Ott, V.L., Cambier, J.C., Kappler, J., Marrack, P., Swanson, B.J. Nat. Immunol. (2003) [Pubmed]
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