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Chemical Compound Review

AG-G-81008     (5S,12R)-5,12-dihydroxyicosa- 6,8,10,14...

Synonyms: AG-L-65953, KBioGR_000084, KBioSS_000084, CBiol_001847, CBiol_001893, ...
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Disease relevance of LEUKOTRIENE B4


High impact information on LEUKOTRIENE B4


Chemical compound and disease context of LEUKOTRIENE B4


Biological context of LEUKOTRIENE B4


Anatomical context of LEUKOTRIENE B4


Associations of LEUKOTRIENE B4 with other chemical compounds


Gene context of LEUKOTRIENE B4


Analytical, diagnostic and therapeutic context of LEUKOTRIENE B4


  1. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Helgadottir, A., Manolescu, A., Thorleifsson, G., Gretarsdottir, S., Jonsdottir, H., Thorsteinsdottir, U., Samani, N.J., Gudmundsson, G., Grant, S.F., Thorgeirsson, G., Sveinbjornsdottir, S., Valdimarsson, E.M., Matthiasson, S.E., Johannsson, H., Gudmundsdottir, O., Gurney, M.E., Sainz, J., Thorhallsdottir, M., Andresdottir, M., Frigge, M.L., Topol, E.J., Kong, A., Gudnason, V., Hakonarson, H., Gulcher, J.R., Stefansson, K. Nat. Genet. (2004) [Pubmed]
  2. Leukotriene B4 produces hyperalgesia that is dependent on polymorphonuclear leukocytes. Levine, J.D., Lau, W., Kwiat, G., Goetzl, E.J. Science (1984) [Pubmed]
  3. High-altitude pulmonary edema. Characteristics of lung lavage fluid. Schoene, R.B., Hackett, P.H., Henderson, W.R., Sage, E.H., Chow, M., Roach, R.C., Mills, W.J., Martin, T.R. JAMA (1986) [Pubmed]
  4. Reperfusion pulmonary edema. Klausner, J.M., Paterson, I.S., Mannick, J.A., Valeri, R., Shepro, D., Hechtman, H.B. JAMA (1989) [Pubmed]
  5. Reversible abnormal nonadherence to glass and responsiveness to chemoattractants of leukocytes from patients with advanced cancer. Thomson, D.M. J. Natl. Cancer Inst. (1984) [Pubmed]
  6. Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. Lee, T.H., Hoover, R.L., Williams, J.D., Sperling, R.I., Ravalese, J., Spur, B.W., Robinson, D.R., Corey, E.J., Lewis, R.A., Austen, K.F. N. Engl. J. Med. (1985) [Pubmed]
  7. Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2. Bonventre, J.V., Huang, Z., Taheri, M.R., O'Leary, E., Li, E., Moskowitz, M.A., Sapirstein, A. Nature (1997) [Pubmed]
  8. A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Yokomizo, T., Izumi, T., Chang, K., Takuwa, Y., Shimizu, T. Nature (1997) [Pubmed]
  9. The PPARalpha-leukotriene B4 pathway to inflammation control. Devchand, P.R., Keller, H., Peters, J.M., Vazquez, M., Gonzalez, F.J., Wahli, W. Nature (1996) [Pubmed]
  10. Metabolism of arachidonic acid in acetic acid colitis in rats. Similarity to human inflammatory bowel disease. Sharon, P., Stenson, W.F. Gastroenterology (1985) [Pubmed]
  11. Mechanisms underlying the protective effects of interleukin 1 in experimental nonsteroidal anti-inflammatory drug gastropathy. Wallace, J.L., Keenan, C.M., Cucala, M., Mugridge, K.G., Parente, L. Gastroenterology (1992) [Pubmed]
  12. Exacerbation of experimental colitis by nonsteroidal anti-inflammatory drugs is not related to elevated leukotriene B4 synthesis. Wallace, J.L., Keenan, C.M., Gale, D., Shoupe, T.S. Gastroenterology (1992) [Pubmed]
  13. Eicosapentaenoic acid in cystic fibrosis: evidence of a pathogenetic role for leukotriene B4. Lawrence, R., Sorrell, T. Lancet (1993) [Pubmed]
  14. Chemotaxis inhibitory protein of Staphylococcus aureus, a bacterial antiinflammatory agent. de Haas, C.J., Veldkamp, K.E., Peschel, A., Weerkamp, F., Van Wamel, W.J., Heezius, E.C., Poppelier, M.J., Van Kessel, K.P., van Strijp, J.A. J. Exp. Med. (2004) [Pubmed]
  15. A monoclonal antibody recognizing very late activation antigen-4 inhibits eosinophil accumulation in vivo. Weg, V.B., Williams, T.J., Lobb, R.R., Nourshargh, S. J. Exp. Med. (1993) [Pubmed]
  16. Crystal-induced neutrophil activation. IV. Specific inhibition of tyrosine phosphorylation by colchicine. Roberge, C.J., Gaudry, M., de Médicis, R., Lussier, A., Poubelle, P.E., Naccache, P.H. J. Clin. Invest. (1993) [Pubmed]
  17. Mono- and dihydroxyeicosatetraenoic acids alter calcium homeostasis in rabbit neutrophils. Naccache, P.H., Sha'afi, R.I., Borgeat, P., Goetzl, E.J. J. Clin. Invest. (1981) [Pubmed]
  18. Leukocyte adhesion in angiogenic blood vessels. Role of E-selectin, P-selectin, and beta2 integrin in lymphotoxin-mediated leukocyte recruitment in tumor microvessels. Borgström, P., Hughes, G.K., Hansell, P., Wolitsky, B.A., Sriramarao, P. J. Clin. Invest. (1997) [Pubmed]
  19. The C5a chemoattractant receptor mediates mucosal defence to infection. Höpken, U.E., Lu, B., Gerard, N.P., Gerard, C. Nature (1996) [Pubmed]
  20. Mast cell-dependent migration of effector CD8+ T cells through production of leukotriene B4. Ott, V.L., Cambier, J.C., Kappler, J., Marrack, P., Swanson, B.J. Nat. Immunol. (2003) [Pubmed]
  21. Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo. Collins, P.D., Marleau, S., Griffiths-Johnson, D.A., Jose, P.J., Williams, T.J. J. Exp. Med. (1995) [Pubmed]
  22. Leukotriene B4, an activation product of mast cells, is a chemoattractant for their progenitors. Weller, C.L., Collington, S.J., Brown, J.K., Miller, H.R., Al-Kashi, A., Clark, P., Jose, P.J., Hartnell, A., Williams, T.J. J. Exp. Med. (2005) [Pubmed]
  23. Fibrin regulates neutrophil migration in response to interleukin 8, leukotriene B4, tumor necrosis factor, and formyl-methionyl-leucyl-phenylalanine. Loike, J.D., el Khoury, J., Cao, L., Richards, C.P., Rascoff, H., Mandeville, J.T., Maxfield, F.R., Silverstein, S.C. J. Exp. Med. (1995) [Pubmed]
  24. Suppression of leukotriene B4 biosynthesis by endogenous adenosine in ligand-activated human neutrophils. Krump, E., Picard, S., Mancini, J., Borgeat, P. J. Exp. Med. (1997) [Pubmed]
  25. Adherence of neutrophils to cultured human microvascular endothelial cells. Stimulation by chemotactic peptides and lipid mediators and dependence upon the Mac-1, LFA-1, p150,95 glycoprotein family. Tonnesen, M.G., Anderson, D.C., Springer, T.A., Knedler, A., Avdi, N., Henson, P.M. J. Clin. Invest. (1989) [Pubmed]
  26. Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins. Levy, B.D., Romano, M., Chapman, H.A., Reilly, J.J., Drazen, J., Serhan, C.N. J. Clin. Invest. (1993) [Pubmed]
  27. The leukotriene B4 receptor functions as a novel type of coreceptor mediating entry of primary HIV-1 isolates into CD4-positive cells. Owman, C., Garzino-Demo, A., Cocchi, F., Popovic, M., Sabirsh, A., Gallo, R.C. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  28. Modulation and induction of eosinophil chemotaxis by granulocyte-macrophage colony-stimulating factor and interleukin-3. Warringa, R.A., Koenderman, L., Kok, P.T., Kreukniet, J., Bruijnzeel, P.L. Blood (1991) [Pubmed]
  29. Leukotriene B4 plays a pivotal role in CD40-dependent activation of chronic B lymphocytic leukemia cells. Runarsson, G., Liu, A., Mahshid, Y., Feltenmark, S., Pettersson, A., Klein, E., Björkholm, M., Claesson, H.E. Blood (2005) [Pubmed]
  30. Regulation of dendritic cell migration and adaptive immune response by leukotriene B4 receptors: a role for LTB4 in up-regulation of CCR7 expression and function. Del Prete, A., Shao, W.H., Mitola, S., Santoro, G., Sozzani, S., Haribabu, B. Blood (2007) [Pubmed]
  31. Triggering of human monocyte activation through CD69, a member of the natural killer cell gene complex family of signal transducing receptors. De Maria, R., Cifone, M.G., Trotta, R., Rippo, M.R., Festuccia, C., Santoni, A., Testi, R. J. Exp. Med. (1994) [Pubmed]
  32. Intravenous infusion of tridocosahexaenoyl-glycerol emulsion into rabbits. Effects on leukotriene B4/5 production and fatty acid composition of plasma and leukocytes. Nakamura, N., Hamazaki, T., Yamazaki, K., Taki, H., Kobayashi, M., Yazawa, K., Ibuki, F. J. Clin. Invest. (1993) [Pubmed]
  33. Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondyloarthritis. Klickstein, L.B., Shapleigh, C., Goetzl, E.J. J. Clin. Invest. (1980) [Pubmed]
  34. Neutrophil accumulation in the lung in alpha 1-antitrypsin deficiency. Spontaneous release of leukotriene B4 by alveolar macrophages. Hubbard, R.C., Fells, G., Gadek, J., Pacholok, S., Humes, J., Crystal, R.G. J. Clin. Invest. (1991) [Pubmed]
  35. Dietary supplementation with fish oil in ulcerative colitis. Stenson, W.F., Cort, D., Rodgers, J., Burakoff, R., DeSchryver-Kecskemeti, K., Gramlich, T.L., Beeken, W. Ann. Intern. Med. (1992) [Pubmed]
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