Preventing DNA re-replication--divergent safeguards in yeast and metazoa.
Eukaryotes employ redundant mechanisms to limit the replication of genomic DNA to only once per cycle. These mechanisms prevent DNA re-replication by restricting the assembly of the pre-replication complex to the cell cycle stages of late mitosis and G1 phase so that the re-initiation of DNA replication cannot occur during S phase. Here we discuss the conserved yet divergent mechanisms of replication control employed in yeast and metazoan species, including a perspective on the newly uncovered role of the CUL-4 ubiquitin ligase as a central regulator of DNA replication in the nematode Caenorhabditis elegans.[1]References
- Preventing DNA re-replication--divergent safeguards in yeast and metazoa. Feng, H., Kipreos, E.T. Cell Cycle (2003) [Pubmed]
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