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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Satisfaction with onychomycosis treatment. Pulse versus continuous dosing.

The purpose of this study, which involved two dermatology clinics and two podiatric medical clinics, was to determine whether a difference exists in patient-reported satisfaction and compliance between continuous terbinafine therapy and pulse-dose itraconazole therapy for the treatment of toenail onychomycosis. Patients in this multicenter, open-label, cross-sectional study had previously completed treatment with either oral terbinafine or oral itraconazole for toenail onychomycosis. Patients were interviewed by telephone to assess clinical outcomes, compliance, and satisfaction with treatment; clinical data were collected by medical chart review. Patients reported significantly greater ease and convenience of treatment and higher overall satisfaction with continuous terbinafine therapy compared with pulse-dose itraconazole therapy.[1]


  1. Satisfaction with onychomycosis treatment. Pulse versus continuous dosing. Warshaw, E.M., Bowman, T., Bodman, M.A., Kim, J.J., Silva, S., Mathias, S.D. Journal of the American Podiatric Medical Association. (2003) [Pubmed]
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