The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Modulation of glutamate agonist-induced influx of calcium into neurons by gamma-L-glutamyl and beta-L-aspartyl dipeptides.

Gamma-L-Glutamate and beta-L-aspartate dipeptides, present in the mammalian brain with a yet unknown function, were shown to affect the influx of Ca2+ into cultured cerebellar granule cells. The most active peptides, gamma-L-glutamyl-L-aspartate, gamma-L-glutamyl-L-glutamate and gamma-L-glutamylglycine, enhanced the basal influx but inhibited the glutamate-activated influx of Ca2+ in a dose-dependent manner. Gamma-L-Glutamyl-L-aspartate, the strongest inhibitor of the glutamate-activated influx of Ca2+, exhibited selective Mg(2+)-dependent antagonism in the N-methyl-D-aspartate (NMDA)-activated influx of Ca2+. This finding may explain its previously shown deleterious effects on the long-term memory. On the other hand, gamma-L-glutamyl-L-aspartate enhanced alone the entry of Ca2+ into neurons. This effect was antagonized by the non-NMDA antagonists 6-nitro-7-cyanoquinoxaline-2,3-dione (CNQX) and 6,7-dinitroquinoxaline-2,3-dione (DNQX), suggesting a non-NMDA receptor-mediated action, that may also be involved in excitotoxicity in some neurodegenerative disorders.[1]


WikiGenes - Universities