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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Effect of indomethacin plus ranitidine in advanced melanoma patients on high-dose interleukin-2.

Preclinical models of advanced melanoma have shown that chronic indomethacin therapy combined with interleukin 2 (IL-2) can eradicate experimental metastases. A phase II trial was done in patients with advanced melanoma. Indomethacin and ranitidine were begun at least one week before IL-2. Of the objective responses in 3 patients, 2 were achieved on ranitidine and indomethacin alone, before start of IL-2. Indomethacin and ranitidine may be responsible for some responses in melanoma patients previously attributed to IL-2.[1]

References

  1. Effect of indomethacin plus ranitidine in advanced melanoma patients on high-dose interleukin-2. Mertens, W.C., Bramwell, V.H., Gwadry-Sridhar, F., Romano, W., Banerjee, D., Lala, P.K. Lancet (1992) [Pubmed]
 
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